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Strain: SS-Chr 7BN/Mcwi

Symbol: SS-Chr 7BN/Mcwi
Strain: SS-Chr 7BN
Substrain: Mcwi
RGD ID: 629515
Citation ID: RRID:RGD_629515
Ontology ID: RS:0000807
Previously known as: SS-7BN/Mcwi; SS-7BN/Mcwi;SS-Chr 7BN/Mcwi; SS-Chr 7BN/Mcwi
Type: consomic
Source: PhysGen
Origin: A cross of SS and BN strains which results in a SS genomic background with a BN chromosome introgressed
Coat Color: albino
Last Known Status: Cryopreserved Sperm





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Mammalian Phenotype

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Clinical Measurement
heart rate
left ventricular diastolic blood pressure
left ventricular systolic blood pressure
mean arterial blood pressure
body weight
body temperature
left ventricular developed pressure
red blood cell count
blood hemoglobin level
blood neutrophil count
blood lymphocyte count
blood monocyte count
blood eosinophil count
hematocrit
mean corpuscular volume
plasma anion gap
heart wet weight
heart weight to body weight ratio
lung dry weight to body weight ratio
heart right ventricle weight to left ventricle weight ratio
plasma renin activity level
minute ventilation
arterial blood flow rate
tidal volume
partial pressure of blood carbon dioxide (Pco2)
percent change in ventilation
respiration rate
mean corpuscular hemoglobin
mean corpuscular hemoglobin concentration
absolute change in partial pressure of blood carbon dioxide
absolute change in partial pressure of blood oxygen
absolute change in blood pH
serum total cholesterol level
total white blood cell count
serum total bilirubin level
blood pH
partial pressure of blood oxygen
serum bicarbonate level
serum chloride level
serum potassium level
serum sodium level
serum calcium level
percent change in respiration rate
percent change in tidal volume
absolute change in mean arterial blood pressure
absolute change in heart rate
plasma creatinine level
serum phosphate level
serum glucose level
serum albumin level
serum alanine aminotransferase activity level
serum alkaline phosphatase activity level
serum aspartate aminotransferase activity level
serum urea nitrogen level
serum total protein level
time to onset of heart contraction
time to peak heart contraction
heart contraction pressure
heart left ventricle infarction weight to total heart left ventricle weight ratio
absolute change in body temperature
calculated pulmonary vascular resistance normalized to body weight
FAPGG metabolism-surface area product
methylene blue metabolism-surface area product without auto-oxidation
methylene blue metabolism-surface area product after auto-oxidation
methylene blue to FAPGG metabolism-surface area product ratio
dose of methacholine at which pulmonary conductance is half its pretreatment value
fractional change in blood vessel diameter per unit change in intravascular pressure
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50)
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50)
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)
concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)
maximum contractile force per wet weight of aorta
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel
sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel
hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel
percent change in heart rate
percent change in arterial blood flow rate
percent change in left ventricular developed pressure
percent change in left ventricular systolic blood pressure
urine total protein excretion rate
urine albumin excretion rate
urine sodium excretion rate
urine potassium excretion rate
creatinine clearance
heart effluent lactate dehydrogenase activity level normalized to heart weight
serum globulin level

References

References - curated
# Reference Title Reference Citation
1. Sex-Specific Differences in Chromosome-Dependent Regulation of Vascular Reactivity in Female Consomic Rat Strains from a SS x BN Cross. Kunert MP, etal., Am J Physiol Regul Integr Comp Physiol. 2008 May 28;.
2. Consomic strategies to localize genomic regions related to vascular reactivity in the Dahl salt-sensitive rat. Kunert MP, etal., Physiol Genomics. 2006 Aug 16;26(3):218-25. Epub 2006 Jun 13.
3. Chromosome substitution reveals the genetic basis of Dahl salt-sensitive hypertension and renal disease. Mattson DL, etal., Am J Physiol Renal Physiol. 2008 Sep;295(3):F837-42. Epub 2008 Jul 23.
4. PhysGen Strains PhysGen strains
5. RGD Strain RSO annotation pipeline RGD Automated Pipelines
6. Dissecting the genetic basis of kidney tubule response to hyperoxaluria using chromosome substitution strains. Wiessner JH, etal., Am J Physiol Renal Physiol. 2009 Aug;297(2):F301-6. Epub 2009 Jun 3.

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_drgs_chems The aortic rings of animals on low-salt diet and high salt diet were more sensitive to phenylephrine as compared to the parental SS. 1598768
strain_life_disease The blood pressure of females is 120 mmHg and of males is 112 mmHg. 629526
strain_other The average weight of females is 191g and of males 274g. 629526
strain_reproduction The average litter size is 8.3 pups and the average generation time is 40 days. 629526

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-12 SS-Chr 7BN/Mcwi    SS-Chr 7BN/Mcwi    Name updated 68913 APPROVED