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General

Strain: SS-Chr 2^BN/Mcwi
Symbol:	SS-Chr 2^BN/Mcwi
Strain:	SS-Chr 2^BN
Substrain:	Mcwi
RGD ID:	629511
Citation ID:	RRID:RGD_629511
Ontology ID:	RS:0000802
Also Known As:	SS-2^BN/Mcwi;SS-Chr 2BN/Mcwi; SS-Chr 2BN/Mcwi; SS-2BN/Mcwi; SS-Chr 2^[BN]/Mcwi
Type:	consomic
Available Source:	Not Available
Origination:	PhysGen
Description:	A cross of SS and BN strains which results in a SS genomic background with a BN chromosome introgressed
Coat Color:	albino
Last Known Status:	Cryopreserved Sperm

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Albuminuria (IAGP)

glomerulosclerosis (IAGP)

Urinary Calculi (IAGP)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal cytokine secretion (IAGP)

decreased mean systemic arterial blood pressure (IAGP)

decreased urine albumin level (IAGP)

glomerulosclerosis (IAGP)

hyperoxaluria (IAGP)

increased interleukin-10 secretion (IAGP)

increased tumor necrosis factor secretion (IAGP)

increased vasoconstriction (IAGP)

Phenotype Values via PhenoMiner Click to see Annotation Detail View

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Clinical Measurement

heart rate

systolic blood pressure

left ventricular diastolic blood pressure

left ventricular systolic blood pressure

mean arterial blood pressure

body weight

body temperature

left ventricular developed pressure

red blood cell count

blood hemoglobin level

blood neutrophil count

blood lymphocyte count

blood monocyte count

blood eosinophil count

hematocrit

mean corpuscular volume

plasma anion gap

heart wet weight

heart weight to body weight ratio

lung dry weight to body weight ratio

heart right ventricle weight to left ventricle weight ratio

plasma renin activity level

minute ventilation

arterial blood flow rate

tidal volume

partial pressure of blood carbon dioxide (Pco2)

percent change in ventilation

respiration rate

mean corpuscular hemoglobin

mean corpuscular hemoglobin concentration

absolute change in partial pressure of blood carbon dioxide

absolute change in partial pressure of blood oxygen

absolute change in blood pH

serum total cholesterol level

total white blood cell count

serum total bilirubin level

blood pH

partial pressure of blood oxygen

serum bicarbonate level

serum chloride level

serum potassium level

serum sodium level

serum calcium level

percent change in respiration rate

percent change in tidal volume

absolute change in mean arterial blood pressure

absolute change in heart rate

plasma creatinine level

serum phosphate level

serum glucose level

serum albumin level

serum alanine aminotransferase activity level

serum alkaline phosphatase activity level

serum aspartate aminotransferase activity level

serum urea nitrogen level

serum total protein level

time to onset of heart contraction

time to peak heart contraction

heart contraction pressure

heart left ventricle infarction weight to total heart left ventricle weight ratio

absolute change in body temperature

calculated pulmonary vascular resistance normalized to body weight

FAPGG metabolism-surface area product

methylene blue metabolism-surface area product without auto-oxidation

methylene blue metabolism-surface area product after auto-oxidation

methylene blue to FAPGG metabolism-surface area product ratio

dose of methacholine at which pulmonary conductance is half its pretreatment value

fractional change in blood vessel diameter per unit change in intravascular pressure

concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50)

logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50)

concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)

logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)

concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)

logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)

maximum contractile force per wet weight of aorta

acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel

sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel

hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel

percent change in heart rate

percent change in arterial blood flow rate

percent change in left ventricular developed pressure

percent change in left ventricular systolic blood pressure

urine total protein excretion rate

urine albumin excretion rate

urine sodium excretion rate

urine potassium excretion rate

creatinine clearance

heart effluent lactate dehydrogenase activity level normalized to heart weight

serum globulin level

renal afferent arteriole diameter

References

References - curated

#	Reference Title	Reference Citation
1.	Sex-Specific Differences in Chromosome-Dependent Regulation of Vascular Reactivity in Female Consomic Rat Strains from a SS x BN Cross.	Kunert MP, etal., Am J Physiol Regul Integr Comp Physiol. 2008 May 28;.
2.	Consomic strategies to localize genomic regions related to vascular reactivity in the Dahl salt-sensitive rat.	Kunert MP, etal., Physiol Genomics. 2006 Aug 16;26(3):218-25. Epub 2006 Jun 13.
3.	Chromosome substitution reveals the genetic basis of Dahl salt-sensitive hypertension and renal disease.	Mattson DL, etal., Am J Physiol Renal Physiol. 2008 Sep;295(3):F837-42. Epub 2008 Jul 23.
4.	p66Shc regulates renal vascular tone in hypertension-induced nephropathy.	Miller B, etal., J Clin Invest. 2016 Jul 1;126(7):2533-46. doi: 10.1172/JCI75079. Epub 2016 Jun 6.
5.	PhysGen Strains	PhysGen strains
6.	RGD Strain RSO annotation pipeline	RGD Automated Pipelines
7.	Immune regulation and vascular inflammation in genetic hypertension.	Viel EC, etal., Am J Physiol Heart Circ Physiol. 2010 Mar;298(3):H938-44. Epub 2009 Dec 31.
8.	Dissecting the genetic basis of kidney tubule response to hyperoxaluria using chromosome substitution strains.	Wiessner JH, etal., Am J Physiol Renal Physiol. 2009 Aug;297(2):F301-6. Epub 2009 Jun 3.

Region

Additional Information

RGD Curation Notes

Note Type	Note	Reference
strain_drgs_chems	The aortic rings of animals on high-salt diet were more sensitive to acetylcholine as compared to the parental SS.	1598768
strain_drgs_chems	The aortic rings of females on low-salt diet were less sensitive to phenylephrine as compared to the parental SS.	2293556
strain_life_disease	The blood pressure of females is 124 mmHg and of males is 127 mmHg.	629526
strain_other	The average weight of females is 174g and of males 273g.	629526
strain_reproduction	The average litter size is 8.6 pups and the average generation time is 53 days.	629526

Nomenclature History

Date	Current Symbol	Previous Symbol	Description	Reference	Status
2013-10-09	SS-Chr 2^BN/Mcwi	SS-Chr 2^BN/Mcwi	Name updated	68913	APPROVED
2013-10-09	SS-Chr 2^BN/Mcwi	SS-Chr 2^BN/Mcwi	Name updated	68913	APPROVED
2013-08-12	SS-Chr 2^BN/Mcwi	SS-Chr 2^BN/Mcwi	Name updated	68913	APPROVED

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Strain: SS-Chr 2BN/Mcwi

Mammalian Phenotype

Related Phenotype Data for Term "SS-Chr 2BN/Mcwi" (RS:0000802)

Strain: SS-Chr 2^BN/Mcwi