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Strain Registration

Strain: LE/Stm

Symbol: LE/Stm
Strain: LE
Substrain: Stm
RGD ID: 629485
Citation ID: RRID:RGD_629485
Ontology ID: RS:0000431
Previously known as: MDC-02-14; NBRP Rat No: 0139
Type: inbred
Source: National BioResource Project for the Rat in Japan
Origin: The LE/Stm rats were introduced into Saitama Cancer Center Research Institute in 1969 from a closed colony of Long Evans rats maintained in the Ben May Laboratory for Cancer Research, University of Chicago. A mutant with red-eyed dilution was found in 1970 in the Long-Evans colony, and the mutation was fixed by selective mating. Thereafter, they were maintained by sister-brother mating more than F50.
Inbred Generations: F50
Last Known Status: Live Animals; Cryopreserved Sperm
Research Usage Diabetes Obesity; Cancer





Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
Options:  View chart  |  Download data table  |  View expanded data table

Clinical Measurement
heart rate
systolic blood pressure
body weight
body temperature
red blood cell count
blood hemoglobin level
white blood cell count
platelet count
hematocrit
mean corpuscular volume
plasma glucose level
plasma aspartate aminotransferase activity level
plasma alanine aminotransferase activity level
plasma alkaline phosphatase activity level
plasma total protein level
plasma albumin level
plasma phosphate level
plasma chloride level
plasma sodium level
plasma potassium level
heart wet weight
heart weight to body weight ratio
both kidneys wet weight
lung wet weight
urine potassium level
urine sodium level
brain weight to body weight ratio
both kidneys wet weight as percentage of body weight
liver weight as percentage of body weight
spleen weight to body weight ratio
brain wet weight
lung weight to body weight ratio
liver wet weight
both adrenal glands wet weight
spleen wet weight
both testes wet weight
activated partial thromboplastin time
prothrombin time
timed urine volume
mean corpuscular hemoglobin
mean corpuscular hemoglobin concentration
blood basophil count to total leukocyte count ratio
blood eosinophil count to total leukocyte count ratio
blood lymphocyte count to total leukocyte count ratio
blood monocyte count to total leukocyte count ratio
total plasma calcium level
urine chloride level
plasma creatinine level
plasma triglyceride level
plasma total cholesterol level
plasma urea nitrogen level
both adrenal glands weight to body weight ratio
plasma high density lipoprotein cholesterol level
plasma low density lipoprotein cholesterol level
both testes wet weight to body weight ratio
percentage of study population developing leukemia during a period of time
urine sodium excretion rate to body weight ratio
post-insult time to onset of leukemia
post-insult time to onset of T-cell lymphoma
percentage of study population developing T-cell lymphomas during a period of time
timed urine volume to body weight ratio
urine chloride excretion rate to body weight ratio
urine potassium excretion rate to body weight ratio
plasma total bilirubin level
blood segmented neutrophil count to total leukocyte count ratio
blood band neutrophil count to total leukocyte count ratio
non-specified leukocyte count to total leukocyte count ratio
plasma albumin to plasma total protein ratio

References

References - curated
# Reference Title Reference Citation
1. Identification of QTLs involved in the development of amygdala kindling in the rat. Hashimoto R, etal., Exp Anim. 2013;62(3):181-7.
2. Propylnitrosourea-induced T-lymphomas in LEXF RI strains of rats: genetic analysis. Lu LM, etal., Br J Cancer 1999 May;80(5-6):855-61.
3. A set of highly informative rat simple sequence length polymorphism (SSLP) markers and genetically defined rat strains. Mashimo T, etal., BMC Genet. 2006 Apr 4;7:19.
4. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
5. RGD Strain RSO annotation pipeline RGD Automated Pipelines
6. SNP and haplotype mapping for genetic analysis in the rat. Saar K, etal., Nat Genet. 2008 May;40(5):560-6.
7. The LEXF: a new set of rat recombinant inbred strains between LE/Stm and F344. Shisa H, etal., Mamm Genome 1997 May;8(5):324-7.

Region

Damaging Variants
Number of Damaging Variants
SampleRnor_6.0Rnor_5.0RGSC_v3.4
LE/Stm (KNAW) 544
LE/Stm (ICL) 666
LE/Stm (Illumina) (KNAW) 851
LE/Stm (SOLiD) (KNAW) 618
LE/Stm (KyushuU) 1323
LE/Stm (RGD) 1213
LE/Stm (2019) 2904
LE/Stm (2019)


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_other A BAC library for this strain is available from the RIKEN BioResource Center. 2292911
strain_reproduction Good breeding performance. 628402

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-05-09 LE/Stm    LE/Stm    Name updated 68913 APPROVED
2012-05-09 LE/Stm    LE/Stm    Name updated 68913 APPROVED
2012-01-11 LE/Stm    LE/Stm    Name updated 68913 APPROVED
2012-01-11 LE/Stm    LE/Stm    Name updated 68913 APPROVED