Strain Report - Rat Genome Database

Name: BN/NHsdMcwi
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Strain Registration

General

Strain: BN/NHsdMcwi
Symbol:	BN/NHsdMcwi
Strain:	BN
Substrain:	NHsdMcwi
RGD ID:	61498
RRID:	RGD_61498
Ontology ID:	RS:0000145
Also known as:	MDC-03-05; BN/SsNHsdMcwi;BN/SsNHsdMcw; RRRC:00562; Eve; Brown Norway; BN/3NHsdMcwi
Type:	inbred
Source:	PhysGen, Rat Resource & Research Center
Origin:	Inbred from a single pair of SsN line rats obtained from Harlan Sprague Dawley (Alabama colony). Maintained at the Medical College of Wisconsin since 1995. To confirm homozygosity, the strain was tested with 200 microsatellite markers (genome-wide scan at 20cM) all of which were homozygous for all regions tested (Cowley et al. 2000, Physiol. Genomics. 2:107-115)
Coat Color:	Brown
Inbred Generations:	F21, at MCW since 1995
Last Known Status:	Live Animals; Cryorecovery

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Albuminuria (IAGP)

glomerulosclerosis (IAGP)

hypertension (IAGP)

proteinuria (IAGP)

Urinary Calculi (IAGP)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

decreased body weight (IAGP)

decreased circulating cholesterol level (IAGP)

decreased incidence of tumors by chemical induction (IAGP)

decreased lactate dehydrogenase level (IAGP)

decreased left ventricle developed pressure (IAGP)

decreased mean systemic arterial blood pressure (IAGP)

decreased myocardial infarct size (IAGP)

decreased renin activity (IAGP)

decreased sensitivity to induced morbidity/mortality (IAGP)

decreased triglyceride level (IAGP)

decreased urine albumin level (IAGP)

decreased urine protein level (IAGP)

increased coronary flow rate (IAGP)

increased left ventricle developed pressure (IAGP)

increased time of peak ischemic contracture (IAGP)

Phenotype Values via PhenoMiner Click to see Annotation Detail View

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Clinical Measurement

heart rate

systolic blood pressure

diastolic blood pressure

left ventricular diastolic blood pressure

left ventricular systolic blood pressure

mean arterial blood pressure

body weight

body temperature

left ventricular developed pressure

red blood cell count

blood hemoglobin level

blood neutrophil count

blood lymphocyte count

blood monocyte count

blood eosinophil count

hematocrit

mean corpuscular volume

plasma glucose level

plasma anion gap

heart wet weight

heart left ventricle wet weight

heart right ventricle wet weight

heart weight to body weight ratio

body length, nose to tail

body length, nose to rump

left kidney wet weight

lung dry weight to body weight ratio

heart right ventricle weight to left ventricle weight ratio

plasma renin activity level

urine creatinine level

urine potassium level

urine sodium level

minute ventilation

arterial blood flow rate

tidal volume

timed urine volume

partial pressure of blood carbon dioxide (Pco2)

percent change in ventilation

respiration rate

mean corpuscular hemoglobin

mean corpuscular hemoglobin concentration

absolute change in partial pressure of blood carbon dioxide

absolute change in partial pressure of blood oxygen

absolute change in blood pH

plasma insulin level

serum triglyceride level

serum total cholesterol level

total white blood cell count

total serum bilirubin level

blood pH

partial pressure of blood oxygen

serum bicarbonate level

serum chloride level

serum potassium level

serum sodium level

serum calcium level

percent change in respiration rate

percent change in tidal volume

absolute change in mean arterial blood pressure

absolute change in heart rate

plasma creatinine level

serum phosphate level

serum glucose level

plasma triglyceride level

serum albumin level

serum alanine aminotransferase activity level

serum alkaline phosphatase activity level

serum aspartate aminotransferase activity level

plasma total cholesterol level

serum urea nitrogen level

single kidney wet weight to body weight ratio

plasma high density lipoprotein cholesterol level

serum total protein level

time to onset of heart contraction

time to peak heart contraction

heart contraction pressure

heart left ventricle infarction weight to total heart left ventricle weight ratio

absolute change in body temperature

calculated pulmonary vascular resistance normalized to body weight

FAPGG metabolism-surface area product

methylene blue metabolism-surface area product without auto-oxidation

methylene blue metabolism-surface area product after auto-oxidation

methylene blue to FAPGG metabolism-surface area product ratio

dose of methacholine at which pulmonary conductance is half its pretreatment value

fractional change in blood vessel diameter per unit change in intravascular pressure

concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50)

logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50)

concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)

logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)

concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)

logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)

maximum contractile force per wet weight of aorta

acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel

sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel

hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel

percent change in heart rate

percent change in arterial blood flow rate

percent change in left ventricular developed pressure

percent change in left ventricular systolic blood pressure

urine total protein excretion rate

urine albumin excretion rate

urine sodium excretion rate

urine potassium excretion rate

urine creatinine excretion rate

creatinine clearance

heart effluent lactate dehydrogenase activity level normalized to heart weight

kidney glomerulus diameter

creatinine clearance to body weight ratio

ratio of change in renal blood flow rate to kidney weight

urine total protein excretion rate to body weight ratio

serum globulin level

urine sodium level to body weight ratio

urine sodium level to urine potassium level ratio

References

References - curated


1.	Adamovic T, etal., Cancer Genet Cytogenet. 2008 Oct;186(1):41-8.
2.	Baker JE, etal., Am J Physiol Heart Circ Physiol 2000 Apr;278(4):H1395-400.
3.	Gilibert S, etal., J Hypertens. 2009 Jun;27(6):1186-93.
4.	Gilibert S, etal., Physiol Genomics. 2008 Feb 19;.
5.	Klemcke HG, etal., Shock. 2008 Jun;29(6):748-53.
6.	Kumarasamy S, etal., Mamm Genome. 2010 May 5.
7.	Kunert MP, etal., Am J Physiol Regul Integr Comp Physiol. 2008 May 28;.
8.	Mattson DL, etal., Am J Physiol Renal Physiol. 2008 Sep;295(3):F837-42. Epub 2008 Jul 23.
9.	Moreno C, etal., Physiol Genomics 2003 Nov 11;15(3):243-57. Epub 2003 Oct 07.
10.	Nobrega MA, etal., Diabetes 2004 Mar;53(3):735-42.
11.	Nobrega MA, etal., Physiol Genomics. 2009 Sep 9;39(1):38-46. Epub 2009 Jul 7.
12.	Personal Communication with Rat Resource & Research Center
13.	PhysGen strains
14.	Rangel-Filho A, etal., J Am Soc Nephrol 2005 Apr;16(4):852-6. Epub 2005 Mar 9.
15.	RGD Automated Pipelines
16.	Saar K, etal., Nat Genet. 2008 May;40(5):560-6.
17.	Saavedra JM J Hypertens. 2009 Jun;27(6):1129-33.
18.	Schlick NE, etal., Am J Physiol Cell Physiol. 2006 Dec;291(6):C1183-92. Epub 2006 Jul 19.
19.	Stadnicka A, etal., J Pharmacol Exp Ther. 2009 Sep;330(3):727-35. Epub 2009 Jun 18.
20.	Wiessner JH, etal., Am J Physiol Renal Physiol. 2009 Aug;297(2):F301-6. Epub 2009 Jun 3.

Region

Strain QTL Data

Symbol	Name	Trait
Bp349	Blood pressure QTL 349	arterial blood pressure trait (VT:2000000)
Bp350	Blood pressure QTL 350	arterial blood pressure trait (VT:2000000)
Bp351	Blood pressure QTL 351	arterial blood pressure trait (VT:2000000)
Bp352	Blood pressure QTL 352	arterial blood pressure trait (VT:2000000)
Bp353	Blood pressure QTL 353	arterial blood pressure trait (VT:2000000)
Bp354	Blood pressure QTL 354	arterial blood pressure trait (VT:2000000)
Bp355	Blood pressure QTL 355	arterial blood pressure trait (VT:2000000)
Gluco57	Glucose level QTL 57	blood glucose amount (VT:0000188)
Gluco58	Glucose level QTL 58	blood glucose amount (VT:0000188)
Gluco59	Glucose level QTL 59	blood glucose amount (VT:0000188)
Gluco60	Glucose level QTL 60	blood glucose amount (VT:0000188)
Pur21	Proteinuria QTL 21	urine protein amount (VT:0005160)
Pur22	Proteinuria QTL 22	urine protein amount (VT:0005160)
Rf57	Renal function QTL 57	kidney glomerulus morphology trait (VT:0005325)
Rf58	Renal function QTL 58	kidney glomerulus morphology trait (VT:0005325)
Scl66	Serum cholesterol level QTL 66	blood cholesterol amount (VT:0000180)
Stl24	Serum triglyceride level QTL 24	blood triglyceride amount (VT:0002644)

Damaging Variants

	Number of Damaging Variants
Sample	Rnor_6.0	Rnor_5.0	RGSC_v3.4
BN/NHsdMcwi (KNAW)			84
BN/NHsdMcwi (ICL)			10
BN/NHsdMcwi (2020)	894
BN/NHsdMcwi (2019)	986
BN/NHsdMcwi (2020)
BN/NHsdMcwi (2019)

Additional Information

RGD Curation Notes

Note Type	Note	Reference
strain_drgs_chems	The aortic rings of animals on low-salt diet and high salt-diet were less sensitive to phenylephrine as compared to the parental SS and less sensitive to acetylcholine when on high salt-diet.	1598768
strain_life_disease	These are a suitable model for resistance to myocardial ischemia.	1342469
strain_other	Mitochondrial DNA is 16,313 bp in size	2325144
strain_phys_biochem	Cowley et al. reported the following arterial blood pressure measurements for this strain: Systolic arterial pressure (SAP) averaged 127 +/- 3 mmHg, and diastolic arterial pressure (DAP) averaged 94 +/- 2 mmHg. Mean arterial blood pressure determined during the inactive light cycle of male rats (n = 42) maintained for nearly 4 wk on 8% NaCl rat chow averaged 109 +/- 2 mmHg and ranged from 89 to 145 mmHg. Active MAP of rats on day 2 of recording averaged 114 +/- 4 mmHg, Inactive MAP on the same day averaged 109 +/- 3 mmHg. The reduction of MAP that occurs during the 36 h following sodium depletion averaged 14 +/- 2 mmHg.	629526
strain_reproduction	The average generation is 49 days and the average litter size is 2.7 pups.	629526
strain_reproduction	Cowley et al. maintained their stock on a 0.4% NaCl rat chow as a 0.1%NaCl diet impairs fertility in SS though it has not been tested in BN.	629526

Nomenclature History

Date	Current Symbol	Previous Symbol	Description	Reference	Status
2013-08-12	BN/NHsdMcwi	BN/NHsdMcwi	Name updated	68913	APPROVED
2013-08-12	BN/NHsdMcwi	BN/NHsdMcwi	Name updated	68913	APPROVED
2013-04-15	BN/NHsdMcwi	BN/NHsdMcwi	Name updated	68913	APPROVED
2012-04-06	BN/NHsdMcwi	BN/NHsdMcwi	Name updated	68913	APPROVED
2012-04-06	BN/NHsdMcwi	BN/NHsdMcwi	Name updated	68913	APPROVED

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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Strain: BN/NHsdMcwi

Related Phenotype Data for Term "BN/NHsdMcwi" (RS:0000145)