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Strain Registration

Strain: BN/NHsdMcwi

Symbol: BN/NHsdMcwi
Strain: BN
Substrain: NHsdMcwi
RGD ID: 61498
Citation ID: RRID:RGD_61498
Ontology ID: RS:0000145
Also Known As: MDC-03-05; BN/SsNHsdMcwi;BN/SsNHsdMcw; Eve; Brown Norway; BN/3NHsdMcwi
Type: inbred
Available Source: RGD HRDP, contact Hybrid Rat Diversity Program at HRDP@mcw.edu
Origination: PhysGen
Description: Inbred from a single pair of SsN line rats obtained from Harlan Sprague Dawley (Alabama colony). Maintained at the Medical College of Wisconsin since 1995. To confirm homozygosity, the strain was tested with 200 microsatellite markers (genome-wide scan at 20cM) all of which were homozygous for all regions tested (Cowley et al. 2000, Physiol. Genomics. 2:107-115). The genome of this BN strain is used as the rat reference assembly.
Coat Color: Brown
Inbred Generations: F21, at MCW since 1995
Last Known Status: Live Animals; Cryorecovery
Portal(s): HRDP portal





Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
Options:  View chart  |  Download data table  |  View expanded data table

Clinical Measurement
heart rate
systolic blood pressure
diastolic blood pressure
left ventricular diastolic blood pressure
left ventricular systolic blood pressure
mean arterial blood pressure
body weight
body temperature
left ventricular developed pressure
red blood cell count
blood hemoglobin level
white blood cell count
blood neutrophil count
blood lymphocyte count
blood monocyte count
blood eosinophil count
hematocrit
mean corpuscular volume
plasma glucose level
blood glucose level
plasma total protein level
plasma anion gap
heart wet weight
heart left ventricle wet weight
heart right ventricle wet weight
heart weight to body weight ratio
body length, nose to tail
body length, nose to rump
right kidney wet weight
left kidney wet weight
single kidney wet weight
both kidneys wet weight
lung dry weight to body weight ratio
body mass index (BMI)
heart right ventricle weight to left ventricle weight ratio
plasma renin activity level
urine creatinine level
urine sodium level
minute ventilation
liver wet weight
both adrenal glands wet weight
both testes wet weight
arterial blood flow rate
tidal volume
timed urine volume
partial pressure of blood carbon dioxide (Pco2)
percent change in ventilation
respiration rate
mean corpuscular hemoglobin
mean corpuscular hemoglobin concentration
absolute change in partial pressure of blood carbon dioxide
absolute change in partial pressure of blood oxygen
absolute change in blood pH
total body fat mass
epididymal fat pad weight
serum total cholesterol level
total white blood cell count
serum total bilirubin level
blood pH
partial pressure of blood oxygen
serum bicarbonate level
serum chloride level
serum potassium level
serum sodium level
serum calcium level
percent change in respiration rate
percent change in tidal volume
absolute change in mean arterial blood pressure
absolute change in heart rate
plasma creatinine level
serum phosphate level
serum glucose level
plasma triglyceride level
serum albumin level
serum alanine aminotransferase activity level
serum alkaline phosphatase activity level
serum aspartate aminotransferase activity level
plasma total cholesterol level
serum urea nitrogen level
single kidney wet weight to body weight ratio
urine total protein level
plasma high density lipoprotein cholesterol level
serum total protein level
time to onset of heart contraction
time to peak heart contraction
heart contraction pressure
heart left ventricle infarction weight to total heart left ventricle weight ratio
absolute change in body temperature
calculated pulmonary vascular resistance normalized to body weight
FAPGG metabolism-surface area product
methylene blue metabolism-surface area product without auto-oxidation
methylene blue metabolism-surface area product after auto-oxidation
methylene blue to FAPGG metabolism-surface area product ratio
dose of methacholine at which pulmonary conductance is half its pretreatment value
fractional change in blood vessel diameter per unit change in intravascular pressure
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50)
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50)
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)
concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)
maximum contractile force per wet weight of aorta
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel
sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel
hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel
percent change in heart rate
percent change in arterial blood flow rate
percent change in left ventricular developed pressure
percent change in left ventricular systolic blood pressure
urine total protein excretion rate
urine albumin excretion rate
urine sodium excretion rate
urine potassium excretion rate
urine creatinine excretion rate
creatinine clearance
heart effluent lactate dehydrogenase activity level normalized to heart weight
heart left ventricle weight
pituitary gland wet weight
thymus wet weight
kidney glomerulus diameter
creatinine clearance to body weight ratio
serum thyroxine level
serum triiodothyronine level
average daily food intake weight
calculated water drink intake volume
inguinal fat pad weight
ratio of change in renal blood flow rate to kidney weight
urine total protein excretion rate to body weight ratio
renal fat pad weight
thyroid gland wet weight
serum globulin level
both ovaries wet weight
urine sodium level to body weight ratio
urine sodium level to urine potassium level ratio
plasma insulin level to plasma glucose level ratio
calories absorbed to calorie intake ratio
body weight gain to calories absorbed ratio
interscapular fat pad weight
total body water mass
defecation rate by mass
total body fat-free mass
total body fat mass to total body mass ratio
total body fat-free mass to total body mass ratio
total body water mass to total body mass ratio
timed urine mass
total body lean mass
total body lean mass to total body mass ratio

References

References - curated
# Reference Title Reference Citation
1. Genetic mapping of mammary tumor traits to rat chromosome 10 using a novel panel of consomic rats. Adamovic T, etal., Cancer Genet Cytogenet. 2008 Oct;186(1):41-8.
2. Resistance to myocardial ischemia in five rat strains: is there a genetic component of cardioprotection? Baker JE, etal., Am J Physiol Heart Circ Physiol 2000 Apr;278(4):H1395-400.
3. Genetically defined risk of salt sensitivity in an intercross of Brown Norway and Dahl S rats. Cowley AW Jr, etal., Physiol Genomics 2000 Apr 27;2(3):107-15.
4. Implication of chromosome 13 on hypertension and associated disorders in Lyon hypertensive rats. Gilibert S, etal., J Hypertens. 2009 Jun;27(6):1186-93.
5. THE EFFECTS OF CHROMOSOME 17 ON FEATURES OF THE METABOLIC SYNDROME IN THE LYON HYPERTENSIVE (LH) RAT. Gilibert S, etal., Physiol Genomics. 2008 Feb 19;.
6. Is survival time after hemorrhage a heritable, quantitative trait?: an initial assessment. Klemcke HG, etal., Shock. 2008 Jun;29(6):748-53.
7. Mitochondrial polymorphisms in rat genetic models of hypertension. Kumarasamy S, etal., Mamm Genome. 2010 May 5.
8. Sex-Specific Differences in Chromosome-Dependent Regulation of Vascular Reactivity in Female Consomic Rat Strains from a SS x BN Cross. Kunert MP, etal., Am J Physiol Regul Integr Comp Physiol. 2008 May 28;.
9. Chromosome substitution reveals the genetic basis of Dahl salt-sensitive hypertension and renal disease. Mattson DL, etal., Am J Physiol Renal Physiol. 2008 Sep;295(3):F837-42. Epub 2008 Jul 23.
10. Genomic map of cardiovascular phenotypes of hypertension in female Dahl S rats. Moreno C, etal., Physiol Genomics 2003 Nov 11;15(3):243-57. Epub 2003 Oct 07.
11. Initial characterization of a rat model of diabetic nephropathy. Nobrega MA, etal., Diabetes 2004 Mar;53(3):735-42.
12. Distinct genetic regulation of progression of diabetes and renal disease in the Goto-Kakizaki rat. Nobrega MA, etal., Physiol Genomics. 2009 Sep 9;39(1):38-46. Epub 2009 Jul 7.
13. Data registered by the Rat Resource & Research Center Personal Communication with Rat Resource & Research Center
14. PhysGen Strains PhysGen strains
15. RF-2 gene modulates proteinuria and albuminuria independently of changes in glomerular permeability in the fawn-hooded hypertensive rat. Rangel-Filho A, etal., J Am Soc Nephrol 2005 Apr;16(4):852-6. Epub 2005 Mar 9.
16. RGD Strain RSO annotation pipeline RGD Automated Pipelines
17. SNP and haplotype mapping for genetic analysis in the rat. Saar K, etal., Nat Genet. 2008 May;40(5):560-6.
18. Opportunities and limitations of genetic analysis of hypertensive rat strains. Saavedra JM J Hypertens. 2009 Jun;27(6):1129-33.
19. Sequence analysis of the complete mitochondrial DNA in 10 commonly used inbred rat strains. Schlick NE, etal., Am J Physiol Cell Physiol. 2006 Dec;291(6):C1183-92. Epub 2006 Jul 19.
20. Mechanism of differential cardiovascular response to propofol in Dahl salt-sensitive, Brown Norway, and chromosome 13-substituted consomic rat strains: role of large conductance Ca2+ and voltage-activated potassium channels. Stadnicka A, etal., J Pharmacol Exp Ther. 2009 Sep;330(3):727-35. Epub 2009 Jun 18.
21. Dissecting the genetic basis of kidney tubule response to hyperoxaluria using chromosome substitution strains. Wiessner JH, etal., Am J Physiol Renal Physiol. 2009 Aug;297(2):F301-6. Epub 2009 Jun 3.

Region

Strain QTL Data
Symbol Name Trait
Bp349 Blood pressure QTL 349 arterial blood pressure trait   (VT:2000000)    
Bp350 Blood pressure QTL 350 arterial blood pressure trait   (VT:2000000)    
Bp351 Blood pressure QTL 351 arterial blood pressure trait   (VT:2000000)    
Bp352 Blood pressure QTL 352 arterial blood pressure trait   (VT:2000000)    
Bp353 Blood pressure QTL 353 arterial blood pressure trait   (VT:2000000)    
Bp354 Blood pressure QTL 354 arterial blood pressure trait   (VT:2000000)    
Bp355 Blood pressure QTL 355 arterial blood pressure trait   (VT:2000000)    
Gluco57 Glucose level QTL 57 blood glucose amount   (VT:0000188)    
Gluco58 Glucose level QTL 58 blood glucose amount   (VT:0000188)    
Gluco59 Glucose level QTL 59 blood glucose amount   (VT:0000188)    
Gluco60 Glucose level QTL 60 blood glucose amount   (VT:0000188)    
Pur21 Proteinuria QTL 21 urine protein amount   (VT:0005160)    
Pur22 Proteinuria QTL 22 urine protein amount   (VT:0005160)    
Rf57 Renal function QTL 57 kidney glomerulus morphology trait   (VT:0005325)    
Rf58 Renal function QTL 58 kidney glomerulus morphology trait   (VT:0005325)    
Scl66 Serum cholesterol level QTL 66 blood cholesterol amount   (VT:0000180)    
Stl24 Serum triglyceride level QTL 24 blood triglyceride amount   (VT:0002644)    
Strain Samples in RGD with Damaging Variants (Polyphen)
AssemblySample 
RGSC_v3.4 BN/NHsdMcwi (KNAW) View Damaging Variants
RGSC_v3.4 BN/NHsdMcwi (ICL) View Damaging Variants
Rnor_6.0 BN/NHsdMcwi (2020) View Damaging Variants
Rnor_6.0 BN/NHsdMcwi (2019) View Damaging Variants
mRatBN7.2 BN/NHsdMcwi (2020) View Damaging Variants
mRatBN7.2 BN/NHsdMcwi (2019) View Damaging Variants
mRatBN7.2 BN/NHsdMcwi (2019NG) View Damaging Variants
mRatBN7.2 BN/NHsdMcwi (2021) View Damaging Variants
mRatBN7.2 BN/NHsdMcwi (2022) View Damaging Variants
mRatBN7.2 BN/NHsdMcwi (2023) View Damaging Variants


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_drgs_chems The aortic rings of animals on low-salt diet and high salt-diet were less sensitive to phenylephrine as compared to the parental SS and less sensitive to acetylcholine when on high salt-diet. 1598768
strain_life_disease These are a suitable model for resistance to myocardial ischemia. 1342469
strain_other Mitochondrial DNA is 16,313 bp in size 2325144
strain_phys_biochem Cowley et al. reported the following arterial blood pressure measurements for this strain: Systolic arterial pressure (SAP) averaged 127 +/- 3 mmHg, and diastolic arterial pressure (DAP) averaged 94 +/- 2 mmHg. Mean arterial blood pressure determined during the inactive light cycle of male rats (n = 42) maintained for nearly 4 wk on 8% NaCl rat chow averaged 109 +/- 2 mmHg and ranged from 89 to 145 mmHg. Active MAP of rats on day 2 of recording averaged 114 +/- 4 mmHg, Inactive MAP on the same day averaged 109 +/- 3 mmHg. The reduction of MAP that occurs during the 36 h following sodium depletion averaged 14 +/- 2 mmHg. 629526
strain_reproduction Cowley et al. maintained their stock on a 0.4% NaCl rat chow as a 0.1%NaCl diet impairs fertility in SS though it has not been tested in BN. 629526
strain_reproduction The average generation is 49 days and the average litter size is 2.7 pups. 629526

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-12 BN/NHsdMcwi    BN/NHsdMcwi    Name updated 68913 APPROVED
2013-08-12 BN/NHsdMcwi    BN/NHsdMcwi    Name updated 68913 APPROVED
2013-04-15 BN/NHsdMcwi    BN/NHsdMcwi    Name updated 68913 APPROVED
2012-04-06 BN/NHsdMcwi    BN/NHsdMcwi    Name updated 68913 APPROVED
2012-04-06 BN/NHsdMcwi    BN/NHsdMcwi    Name updated 68913 APPROVED