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Strain Registration

Strain: BN-Lx/Cub

Symbol: BN-Lx/Cub
Strain: BN-Lx
Substrain: Cub
Full Name: Brown Norway with polydactyly-luxate
RGD ID: 61117
Citation ID: RRID:RGD_61117
Ontology ID: RS:0000116
Previously known as: BN-Lx/Cub; MDC-01-26; RGD:737890; BN.Lx/Cub
Type: inbred
Source: Charles University, Department of Biology, Prague
Origin: These were derived by introgressing mutant Lx gene of the polydactylous (PD/Cub) rat onto the BN background.
Inbred Generations: F>20
Last Known Status: Unknown





References

References - curated
# Reference Title Reference Citation
1. A genetic and correlation analysis of liver cholesterol concentration in rat recombinant inbred strains fed a high cholesterol diet. Bottger A, etal., Biochem Biophys Res Commun 1998 May 8;246(1):272-5.
2. Identification of quantitative trait Loci for anxiety and locomotion phenotypes in rat recombinant inbred strains. Conti LH, etal., Behav Genet 2004 Jan;34(1):93-103.
3. Contribution of autosomal loci and the Y chromosome to the stress response in rats. Dumas P, etal., Hypertension 2000 Feb;35(2):568-73
4. Inbred Strains Festing, MFW, Inbred Strains, The Laboratory Rat, 1979, Baker HK, Lindsey JR, Weisbroth SH, 55-72, Academic Press
5. Update to previous Strain Data Festing, MFW, Personal Communication Update, Feb-2000
6. Recombinant inbred and congenic strains of the rat for genetic analysis of limb morphogenesis. Kren V, etal., Folia Biol (Praha) 1996;42(4):159-66.
7. Linkage mapping of the Fos cellular oncogene (Fos) to rat chromosome 6 and its possible role in the regulation of compensatory renal growth. Pravenec M, etal., Folia Biol (Praha) 1998;44(5):151-3.
8. Chromosomal mapping of a major quantitative trait locus regulating compensatory renal growth in the rat. Pravenec M, etal., J Am Soc Nephrol 2000 Jul;11(7):1261-5
9. An analysis of spontaneous hypertension in spontaneously hypertensive rats by means of new recombinant inbred strains. Pravenec M, etal., J Hypertens 1989 Mar;7(3):217-21.
10. RGD Strain RSO annotation pipeline RGD Automated Pipelines
11. SNP and haplotype mapping for genetic analysis in the rat. Saar K, etal., Nat Genet. 2008 May;40(5):560-6.
12. Mapping of quantitative trait loci for seminal vesicle mass and litter size to rat chromosome 8. Zidek V, etal., J Reprod Fertil 1999 Jul;116(2):329-33.

Region

Strain QTL Data
Symbol Name Trait
Anxrr10 Anxiety related response QTL 10 exploratory behavior trait   (VT:0010471)    
Anxrr11 Anxiety related response QTL 11 exploratory behavior trait   (VT:0010471)    
Anxrr3 Anxiety related response QTL 3 exploratory behavior trait   (VT:0010471)    
Anxrr4 Anxiety related response QTL 4 exploratory behavior trait   (VT:0010471)    
Anxrr5 Anxiety related response QTL 5 exploratory behavior trait   (VT:0010471)    
Anxrr6 Anxiety related response QTL 6 exploratory behavior trait   (VT:0010471)    
Anxrr7 Anxiety related response QTL 7 exploratory behavior trait   (VT:0010471)    
Anxrr8 Anxiety related response QTL 8 exploratory behavior trait   (VT:0010471)    
Anxrr9 Anxiety related response QTL 9 exploratory behavior trait   (VT:0010471)    
Btemp1 Thermal response to stress QTL 1 body temperature trait   (VT:0005535)    
Btemp2 Thermal response to stress QTL 2 body temperature trait   (VT:0005535)    
Coreg1 Compensatory renal growth QTL 1 kidney mass   (VT:0002707)    
Coreg2 Compensatory renal growth QTL 2 kidney mass   (VT:0002707)    
Inf1 Infertility severity QTL 1 seminal gland mass   (VT:0010524)    
Plsm1 Polydactyly-luxate syndrome (PLS) morphotypes QTL 1 forelimb integrity trait   (VT:0010562)    
Plsm2 Polydactyly-luxate syndrome (PLS) morphotypes QTL 2 hindlimb integrity trait   (VT:0010563)    
Plsm3 Polydactyly-luxate syndrome (PLS) morphotypes QTL 3 tibia length   (VT:0004357)    
Plsm4 Polydactyly-luxate syndrome (PLS) morphotypes QTL 4 forelimb integrity trait   (VT:0010562)    
Damaging Variants
Number of Damaging Variants
SampleRnor_6.0Rnor_5.0RGSC_v3.4
BN-Lx/Cub (ICL) 7
BN-Lx/Cub (KNAW) 7
BN-Lx/Cub (ICL) 16
BN-Lx/Cub (KNAW) 19


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_anatomy lx, polydactyly-luxate, autosomal recessive, LG VII. The anomaly affects the distal extremities of the hindlegs producing supernumerary digits, predominantly six toes, and a low incidence of mild zeugopodium malformation (2). The expression is variable and strongly influenced by the genetic backround as evidenced by polydactyly-luxate congenic strains: Lew-lx, hindfeet with 7 toes, ? 10% luxation, BP-lx and BN-lx with fore- and hindfoot polydactyly with 6 toes, 100% luxation. BN was further exceptional by expressing the defect as an incomplete dominant trait (3). Application of teratogens increases the expressivity of the lx allele (1). Polydactyly-luxate is independent of the Dpl-syndrome. 1004
strain_anatomy lx, polydactyly-luxate, autosomal recessive, LG VII. The anomaly affects the distal extremities of the hindlegs producing supernumerary digits, predominantly six toes, and a low incidence of mild zeugopodium malformation (2). The expression is variable and strongly influenced by the genetic backround as evidenced by polydactyly-luxate congenic strains: Lew-lx, hindfeet with 7 toes, ? 10% luxation, BP-lx and BN-lx with fore- and hindfoot polydactyly with 6 toes, 100% luxation. BN was further exceptional by expressing the defect as an incomplete dominant trait (3). Application of teratogens increases the expressivity of the lx allele (1). Polydactyly-luxate is independent of the Dpl-syndrome. 634612
strain_phys_biochem The limb defect is associated with acetylesterase-6 (5.3 ? 3.2 cM) on LGVII (4). 1004
strain_phys_biochem The limb defect is associated with acetylesterase-6 (5.3 ? 3.2 cM) on LGVII (4). 634612
strain_phys_biochem When fed a high cholesterol diet, these rats develop two fold higher liver cholesterol concentration than SHR/Ola rats. 629576
strain_phys_biochem This strain was screened for genetic polymorphisms for 100 genomic loci in 55 genes ; Polymorphisms observed in this study can be found in NCBI dbSNP under accession numbers ss12588106 - ss12588203. 737878

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-01-05 BN-Lx/Cub    BN/Cub-Lx    Data Merged 61071 APPROVED