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Strain Registration

Strain: BN-Lx/Cub

Symbol: BN-Lx/Cub
Strain: BN-Lx
Substrain: Cub
Full Name: Brown Norway with polydactyly-luxate
RGD ID: 61117
RRID: RGD_61117
Ontology ID: RS:0000116
Also known as: BN-Lx/Cub; MDC-01-26; RGD:737890; BN.Lx/Cub
Type: inbred
Source: Charles University, Department of Biology, Prague
Origin: These were derived by introgressing mutant Lx gene of the polydactylous (PD/Cub) rat onto the BN background.
Inbred Generations: F>20
Last Known Status: Unknown





References


Region

Strain QTL Data
Symbol Name Trait
Anxrr10 Anxiety related response QTL 10 exploratory behavior trait   (VT:0010471)    
Anxrr11 Anxiety related response QTL 11 exploratory behavior trait   (VT:0010471)    
Anxrr3 Anxiety related response QTL 3 exploratory behavior trait   (VT:0010471)    
Anxrr4 Anxiety related response QTL 4 exploratory behavior trait   (VT:0010471)    
Anxrr5 Anxiety related response QTL 5 exploratory behavior trait   (VT:0010471)    
Anxrr6 Anxiety related response QTL 6 exploratory behavior trait   (VT:0010471)    
Anxrr7 Anxiety related response QTL 7 exploratory behavior trait   (VT:0010471)    
Anxrr8 Anxiety related response QTL 8 exploratory behavior trait   (VT:0010471)    
Anxrr9 Anxiety related response QTL 9 exploratory behavior trait   (VT:0010471)    
Btemp1 Thermal response to stress QTL 1 body temperature trait   (VT:0005535)    
Btemp2 Thermal response to stress QTL 2 body temperature trait   (VT:0005535)    
Coreg1 Compensatory renal growth QTL 1 kidney mass   (VT:0002707)    
Coreg2 Compensatory renal growth QTL 2 kidney mass   (VT:0002707)    
Inf1 Infertility severity QTL 1 seminal gland mass   (VT:0010524)    
Plsm1 Polydactyly-luxate syndrome (PLS) morphotypes QTL 1 forelimb integrity trait   (VT:0010562)    
Plsm2 Polydactyly-luxate syndrome (PLS) morphotypes QTL 2 hindlimb integrity trait   (VT:0010563)    
Plsm3 Polydactyly-luxate syndrome (PLS) morphotypes QTL 3 tibia length   (VT:0004357)    
Plsm4 Polydactyly-luxate syndrome (PLS) morphotypes QTL 4 forelimb integrity trait   (VT:0010562)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_anatomy lx, polydactyly-luxate, autosomal recessive, LG VII. The anomaly affects the distal extremities of the hindlegs producing supernumerary digits, predominantly six toes, and a low incidence of mild zeugopodium malformation (2). The expression is variable and strongly influenced by the genetic backround as evidenced by polydactyly-luxate congenic strains: Lew-lx, hindfeet with 7 toes, ? 10% luxation, BP-lx and BN-lx with fore- and hindfoot polydactyly with 6 toes, 100% luxation. BN was further exceptional by expressing the defect as an incomplete dominant trait (3). Application of teratogens increases the expressivity of the lx allele (1). Polydactyly-luxate is independent of the Dpl-syndrome. 1004
strain_anatomy lx, polydactyly-luxate, autosomal recessive, LG VII. The anomaly affects the distal extremities of the hindlegs producing supernumerary digits, predominantly six toes, and a low incidence of mild zeugopodium malformation (2). The expression is variable and strongly influenced by the genetic backround as evidenced by polydactyly-luxate congenic strains: Lew-lx, hindfeet with 7 toes, ? 10% luxation, BP-lx and BN-lx with fore- and hindfoot polydactyly with 6 toes, 100% luxation. BN was further exceptional by expressing the defect as an incomplete dominant trait (3). Application of teratogens increases the expressivity of the lx allele (1). Polydactyly-luxate is independent of the Dpl-syndrome. 634612
strain_phys_biochem When fed a high cholesterol diet, these rats develop two fold higher liver cholesterol concentration than SHR/Ola rats. 629576
strain_phys_biochem This strain was screened for genetic polymorphisms for 100 genomic loci in 55 genes ; Polymorphisms observed in this study can be found in NCBI dbSNP under accession numbers ss12588106 - ss12588203. 737878
strain_phys_biochem The limb defect is associated with acetylesterase-6 (5.3 ? 3.2 cM) on LGVII (4). 1004
strain_phys_biochem The limb defect is associated with acetylesterase-6 (5.3 ? 3.2 cM) on LGVII (4). 634612

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-01-05 BN-Lx/Cub    BN/Cub-Lx    Data Merged 61071 APPROVED