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Strain: BN/SsN

Symbol: BN/SsN
Strain: BN
Substrain: SsN
RGD ID: 61115
Citation ID: RRID:RGD_61115
Ontology ID: RS:0000154
Also Known As: BN/SsN
Type: inbred
Available Source: Not Available
Origination: NIH Autoimmune Rat Model Repository and Development Center
Description: To N 1972 from Silvers at F34. Silvers began brother-sister matings with selection for histocompatibility in 1958 from a brown mutation in a stock of wild rats maintained by King in a penbred colony.
Genetic Markers: a, b, C, hi Non-agouti brown
Inbred Generations: F65
Last Known Status: Extinct





Experimental Data Annotations    Click to see Annotation Detail View

Rat Strain
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
BN/SsNRatBN/SsN  IEA 7241799 RGD 

Vertebrate Trait
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
BN/SsNRatjoint integrity trait  EXP 61066 RGD 

References

References - curated
# Reference Title Reference Citation
1. Heterogeneous stock rat: a unique animal model for mapping genes influencing bone fragility. Alam I, etal., Bone. 2011 May 1;48(5):1169-77. Epub 2011 Feb 18.
2. Identification of four new quantitative trait loci regulating arthritis severity and one new quantitative trait locus regulating autoantibody production in rats with collagen-induced arthritis. Griffiths MM, etal., Arthritis Rheum 2000 Jun;43(6):1278-89
3. Polymorphisms of the glucocorticoid receptor gene in laboratory and wild rats: steroid binding properties of trinucleotide CAG repeat length variants. Heeley RP, etal., Mamm Genome 1998 Mar;9(3):198-203.
4. Institute for Animal Experimentation University of Tokushima School of Medicine Institute for Animal Experimentation University of Tokushima School of Medicine
5. NIH Rat Strain Data NIH Rat Strain Data
6. RGD Strain RSO annotation pipeline RGD Automated Pipelines
7. Genetic variation in coding regions between and within commonly used inbred rat strains. Smits BM, etal., Genome Res. 2004 Jul;14(7):1285-90.

Region

Strain QTL Data
Symbol Name Trait
Cia11 Collagen induced arthritis QTL 11 joint integrity trait   (VT:0010548)    
Cia12 Collagen induced arthritis QTL 12 joint integrity trait   (VT:0010548)    
Cia14 Collagen induced arthritis QTL 14 joint integrity trait   (VT:0010548)    
Cia24 Collagen induced arthritis QTL 24 joint integrity trait   (VT:0010548)    
Strain Samples in RGD with Damaging Variants (Polyphen)
AssemblySample 
RGSC_v3.4 BN/SsN (KNAW) View Damaging Variants
Rnor_5.0 BN/SsN (KNAW) View Damaging Variants
Rnor_6.0 BN/SsN (MCW) View Damaging Variants
Rnor_6.0 BN/SsN (2020) View Damaging Variants
mRatBN7.2 BN/SsN (2020) View Damaging Variants


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_other Reported to be extinct from the Rat Resource & Research Center as of 26/08/2011. 2292495
strain_phys_biochem This strain was screened for genetic polymorphisms for 100 genomic loci in 55 genes ; Polymorphisms observed in this study can be found in NCBI dbSNP under accession numbers ss12588106 - ss12588203. 737878

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-04-07 BN/SsN    BN/SsN    Name updated 68913 APPROVED
2015-04-07 BN/SsN    BN/SsN    Name updated 68913 APPROVED
2012-04-06 BN/SsN    BN/SsN    Name updated 68913 APPROVED
2012-04-06 BN/SsN    BN/SsN    Name updated 68913 APPROVED
2011-08-26 BN/SsN    BN/SsN    Name updated 68913 APPROVED
2011-08-26 BN/SsN    BN/SsN    Name updated 68913 APPROVED
2011-08-26 BN/SsN    BN/SsN    Name updated 68913 APPROVED
2011-08-26 BN/SsN    BN/SsN    Name updated 68913 APPROVED
2003-11-12 BN/SsN/N  Brown Norway  BN/SsN    Symbol Updated 728213 APPROVED