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Strain: BB/OK

Symbol: BB/OK
Strain: BB
Substrain: OK
Full Name: BioBreeding rat
RGD ID: 61107
Citation ID: RRID:RGD_61107
Ontology ID: RS:0000067
Alleles: Asns;   Cav1;   Cftr;   Cyp51;   Cdk5;   Met;   Smo;   Tac1;   Stx1a;   Hgf
Also Known As: MDC-02-70; NBRP Rat No: 0260
Type: inbred
Available Source: National BioResource Project for the Rat in Japan
Origination: Central Institute for Diabetes, Karlsburg, Germany
Description: This colony was established in 1983, these rats were originally from an outbred colony from Ottawa, Canada.
Coat Color: White
Inbred Generations: F62
Last Known Status: Cryopreserved Sperm
Research Usage Diabetes Obesity; Immunology





Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. High-fat diet protects BB/OK rats from developing type 1 diabetes. Bahr J, etal., Diabetes Metab Res Rev. 2011 Sep;27(6):552-6. doi: 10.1002/dmrr.1207.
2. Segregation of autoimmune type 1 diabetes in a cross between diabetic BB and brown Norway rats. Jackerott M, etal., J Autoimmun 1997 Feb;10(1):35-41.
3. Genetic dissection of autoimmune type I diabetes in the BB rat Jacob HJ, etal., Nat Genet 1992 Sep;2(1):56-60
4. Diabetes and hypertension in rodent models. Kloting I, etal., Ann N Y Acad Sci 1997 Sep 20;827:64-84.
5. Mapping of novel genes predisposing or protecting diabetes development in the BB/OK rat. Kloting I, etal., Biochem Biophys Res Commun 1998 Apr 17;245(2):483-6
6. Genes of SHR rats protect spontaneously diabetic BB/OK rats from diabetes: lessons from congenic BB.SHR rat strains. Kloting I, etal., Biochem Biophys Res Commun 2001 May 4;283(2):399-405.
7. Locus on chromosome 18 cosegregates with diabetes in the BB/OK rat subline. Kloting I, etal., Diabete Metab 1995 Dec;21(5):338-44.
8. Quantitative trait loci for blood glucose confirm diabetes predisposing and protective genes, Iddm4 and Iddm5r, in the spontaneously diabetic BB/OK rat. Kloting I, etal., Int J Mol Med. 1998 Nov;2(5):597-601.
9. Diabetes per se and metabolic state influence gene expression in tissue-dependent manner of BB/OK rats. Kloting N, etal., Diabetes Metab Res Rev. 2005 May-Jun;21(3):281-7.
10. Quantitative trait loci on chromosomes 1 and 4 affect lipid phenotypes in the rat. Kovacs P and Kloting I, Arch Biochem Biophys 1998 Jun 1;354(1):139-43.
11. Mapping of quantitative trait loci for body weight on chromosomes 1 and 4 in the rat. Kovacs P and Kloting I, Biochem Mol Biol Int 1998 Feb;44(2):399-405.
12. Novel quantitative trait loci for blood pressure and related traits on rat chromosomes 1, 10, and 18. Kovacs P, etal., Biochem Biophys Res Commun 1997 Jun 18;235(2):343-8
13. Alleles of the spontaneously hypertensive rat decrease blood pressure at loci on chromosomes 4 and 13. Kovacs P, etal., Biochem Biophys Res Commun 1997 Sep 18;238(2):586-9.
14. Congenic strain confirms putative quantitative trait locus for body weight in the rat. Kovacs P, etal., Mamm Genome 1998 Apr;9(4):294-6.
15. RGD Strain RSO annotation pipeline RGD Automated Pipelines
16. SNP and haplotype mapping for genetic analysis in the rat. Saar K, etal., Nat Genet. 2008 May;40(5):560-6.

Region

Strain QTL Data
Symbol Name Trait
Bp42 Blood pressure QTL 42 arterial blood pressure trait   (VT:2000000)    
Bp43 Blood pressure QTL 43 arterial blood pressure trait   (VT:2000000)    
Bp44 Blood pressure QTL 44 arterial blood pressure trait   (VT:2000000)    
Bp45 Blood pressure QTL 45 arterial blood pressure trait   (VT:2000000)    
Bp46 Blood pressure QTL 46 arterial blood pressure trait   (VT:2000000)    
Bp47 Blood pressure QTL 47 arterial blood pressure trait   (VT:2000000)    
Bp48 Blood pressure QTL 48 arterial blood pressure trait   (VT:2000000)    
Bp79 Blood pressure QTL 79 arterial blood pressure trait   (VT:2000000)    
Bp80 Blood pressure QTL 80 arterial blood pressure trait   (VT:2000000)    
Bw18 Body weight QTL 18 body mass   (VT:0001259)    
Bw20 Body weight QTL 20 body mass   (VT:0001259)    
Bw22 Body weight QTL 22 body mass   (VT:0001259)    
Bw39 Body weight QTL 39 body mass   (VT:0001259)    
Bw40 Body weight QTL 40 body mass   (VT:0001259)    
Iddm10 Insulin dependent diabetes mellitus QTL 10 blood glucose amount   (VT:0000188)    
Iddm16 Insulin dependent diabetes mellitus QTL 16 blood glucose amount   (VT:0000188)    
Iddm4 Insulin dependent diabetes mellitus QTL 4 blood glucose amount   (VT:0000188)    
Iddm5 Insulin dependent diabetes mellitus QTL 5 blood glucose amount   (VT:0000188)    
Iddm6 Insulin dependent diabetes mellitus QTL 6 blood glucose amount   (VT:0000188)    
Iddm8 Insulin dependent diabetes mellitus QTL 8 blood glucose amount   (VT:0000188)    
Iddm9 Insulin dependent diabetes mellitus QTL 9 blood glucose amount   (VT:0000188)    
Scl22 Serum cholesterol level QTL 22 blood cholesterol amount   (VT:0000180)    
Scl4 Serum cholesterol level QTL 4 blood cholesterol amount   (VT:0000180)    
Scl5 Serum cholesterol level QTL 5 blood cholesterol amount   (VT:0000180)    
Sprol1 Serum protein level QTL 1 blood total protein amount   (VT:0005567)    
Stl2 Serum triglyceride level QTL 2 blood triglyceride amount   (VT:0002644)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics 80-100% of male and female BB/OK rats develop spontaneously insulin-dependent type 1 diabetes mellitus at an age of about 90 days; first autoantobodies are detectable at an age of 10 days; first sign of insulitis at an age of 30 days; all animals develop insulitis up to an age of 30 weeks. 1549690
strain_life_disease These animals develop insulin-dependent diabetes. 619667
strain_life_disease These animals develop insulin-dependent diabetes. 619684
strain_reproduction Average litter size at weaning 6.5 pups for diabetic-prone and 7.2 pups for the diabetic-resistant colonies. 61077