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Strain: SHR.BN-(D8Mit5-D8Mgh6)/Ipcv

Symbol: SHR.BN-(D8Mit5-D8Mgh6)/Ipcv
Strain: SHR.BN-(D8Mit5-D8Mgh6)
Substrain: Ipcv
RGD ID: 61106
Citation ID: RRID:RGD_61106
Ontology ID: RS:0000725
Also Known As: SHR.BN-(D8Mit5-D8Mgh6)/Ipcv; SHR.Lx; MDC-03-52; SHR.Lx
Type: congenic
Available Source: Not Available
Origination: Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic
Description: A segment of chr. 8 is transferred from the normotensive BN-Lx/Cub rat to the SHR/Ola.
Last Known Status: Unknown
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2830,848,154 - 61,290,444RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0833,558,660 - 65,717,592RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0833,603,024 - 65,467,051RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.4832,203,394 - 64,762,616RGD_MAPPER_PIPELINERGSC3.4

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype


References - curated
# Reference Title Reference Citation
1. Genomic determinants of triglyceride and cholesterol distribution into lipoprotein fractions in the rat. Hodulova M, etal., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014.
2. Nicotinic receptor gene cluster on rat chromosome 8 in nociceptive and blood pressure hyperresponsiveness. Khan IM, etal., Physiol Genomics 2002 Oct 29;11(2):65-72.
3. Genetic isolation of a region of chromosome 8 that exerts major effects on blood pressure and cardiac mass in the spontaneously hypertensive rat. Kren V, etal., J Clin Invest 1997 Feb 15;99(4):577-81
4. RGD Strain RSO annotation pipeline RGD Automated Pipelines
5. SNP and haplotype mapping for genetic analysis in the rat. Saar K, etal., Nat Genet. 2008 May;40(5):560-6.
6. Effect of renin gene transfer on blood pressure in the spontaneously hypertensive rat. St Lezin E, etal., Hypertension 1998 Jan;31(1 Pt 2):373-7.


Position Markers

Flank 1 / 1 (D8Mit5)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2830,848,154 - 30,848,259 (+)MAPPER
Rnor_6.0833,558,660 - 33,558,764NCBI
Rnor_5.0833,603,024 - 33,603,128UniSTS
RGSC_v3.4832,203,395 - 32,203,499UniSTS
RGSC_v3.4832,203,394 - 32,203,499RGD
RGSC_v3.1832,212,161 - 32,212,265RGD
Celera832,299,483 - 32,299,583UniSTS
RH 3.4 Map8248.5UniSTS
RH 3.4 Map8248.5RGD
RH 2.0 Map8167.4RGD
Cytogenetic Map8q21UniSTS

Flank 2 / 1 (D8Mgh6)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2861,290,298 - 61,290,444 (+)MAPPER
Rnor_6.0865,717,449 - 65,717,592NCBI
Rnor_5.0865,466,908 - 65,467,051UniSTS
RGSC_v3.4864,762,472 - 64,762,616RGD
RGSC_v3.4864,762,473 - 64,762,616UniSTS
RGSC_v3.1864,781,526 - 64,781,670RGD
Celera860,716,475 - 60,716,618UniSTS
RH 2.0 Map8556.8RGD
Cytogenetic Map8q24UniSTS
Strain QTL Data
Symbol Name Trait
Bp273 Blood pressure QTL 273 arterial blood pressure trait   (VT:2000000)    
Bp35 Blood pressure QTL 35 arterial blood pressure trait   (VT:2000000)    
Bw175 Body weight QTL 175 total fat pad mass   (VT:0015008)    
Cm81 Cardiac mass QTL 81 heart mass   (VT:0007028)    
Kidm55 Kidney mass QTL 55 kidney mass   (VT:0002707)    
Livw4 Liver weight QTL 4 liver mass   (VT:0003402)    
Scl69 Serum cholesterol level QTL 69 blood LDL cholesterol amount   (VT:0000181)    
Scl70 Serum cholesterol level QTL 70 blood LDL cholesterol amount   (VT:0000181)    
Scl71 Serum cholesterol level QTL 71 blood LDL cholesterol amount   (VT:0000181)    
Scl72 Serum cholesterol level QTL 72 blood LDL cholesterol amount   (VT:0000181)    
Scl73 Serum cholesterol level QTL 73 blood LDL cholesterol amount   (VT:0000181)    
Scl74 Serum cholesterol level QTL 74 blood LDL cholesterol amount   (VT:0000181)    
Scl75 Serum cholesterol level QTL 75 blood LDL cholesterol amount   (VT:0000181)    
Scl76 Serum cholesterol level QTL 76 blood VLDL cholesterol amount   (VT:0005144)    
Scl77 Serum cholesterol level QTL 77 blood VLDL cholesterol amount   (VT:0005144)    
Scl78 Serum cholesterol level QTL 78 blood VLDL cholesterol amount   (VT:0005144)    
Scl79 Serum cholesterol level QTL 79 blood HDL cholesterol amount   (VT:0000184)    
Scl80 Serum cholesterol level QTL 80 blood LDL cholesterol amount   (VT:0000181)    
Stl33 Serum triglyceride level QTL 33 blood LDL triglyceride amount   (VT:0010699)    
Stl34 Serum triglyceride level QTL 34 blood LDL triglyceride amount   (VT:0010699)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_life_disease Significant decrease in the systolic and diastolic blood pressure was noticed as compared to the SHR strain. Even the cardiac mass was lower. 61512
strain_life_disease Significant decrease in the systolic and diastolic blood pressure was noticed as compared to the SHR strain. Even the cardiac mass was lower. 619652

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-03-07 SHR.BN-(D8Mit5-D8Mgh6)/Ipcv    SHR.BN-(D8Mit5-D8Mgh6)/Ipcv    Name updated 68913 APPROVED
2013-03-07 SHR.BN-(D8Mit5-D8Mgh6)/Ipcv    SHR.BN-(D8Mit5-D8Mgh6)/Ipcv    Name updated 68913 APPROVED