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Strain Registration

Strain: E3

Symbol: E3
Strain: E3
RGD ID: 61013
Citation ID: RRID:RGD_61013
Ontology ID: RS:0000202
Type: inbred
Available Source: Not Available
Description: Kroning, Gottingen from rats of unknown origin selected for fawn hooded phenotype, to Hannover 1957 at F16. To Gottschewski in 1964, then back to Hannover in 1968.
Genetic Markers: a, C, h, r
Coat Color: Fawn hooded
Inbred Generations: F55+?
Last Known Status: Unknown

Substrains
E3/Ztm
E3/ZtmRhd





Experimental Data Annotations    Click to see Annotation Detail View

Rat Strain
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
E3RatE3  IEA 7241799 RGD 

Vertebrate Trait
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
E3Ratblood interleukin-6 amount  EXP 629561 RGD 
E3Ratblood murinoglobulin 1 amount  EXP 629561 RGD 
E3Ratbody mass  EXP 61031 RGD 
E3Ratjoint integrity trait  EXP 61089 RGD 
E3Ratjoint integrity trait  EXP 631225 RGD 
E3Ratnervous system integrity trait  EXP 61031 RGD 
E3Ratorosomucoid 1 amount  EXP 629561 RGD 

References

References - curated
# Reference Title Reference Citation
1. Evidence for common autoimmune disease genes controlling onset, severity, and chronicity based on experimental models for multiple sclerosis and rheumatoid arthritis. Bergsteinsdottir K, etal., J Immunol 2000 Feb 1;164(3):1564-8
2. Inbred Strains Festing, MFW, Inbred Strains, The Laboratory Rat, 1979, Baker HK, Lindsey JR, Weisbroth SH, 55-72, Academic Press
3. Update to previous Strain Data Festing, MFW, Personal Communication Update, Feb-2000
4. Both common and unique susceptibility genes in different rat strains with pristane-induced arthritis. Lu S, etal., Eur J Hum Genet 2002 Aug;10(8):475-83.
5. Rat Strain List M. Festing Rat Strain List
6. Genetic links between the acute-phase response and arthritis development in rats. Olofsson P, etal., Arthritis Rheum 2002 Jan;46(1):259-68.
7. RGD Strain RSO annotation pipeline RGD Automated Pipelines
8. Pristane-induced arthritis in rats: a new model for rheumatoid arthritis with a chronic disease course influenced by both major histocompatibility complex and non-major histocompatibility complex genes. Vingsbo C, etal., Am J Pathol 1996 Nov;149(5):1675-83
9. Genetic control of arthritis onset, severity and chronicity in a model for rheumatoid arthritis in rats. Vingsbo-Lundberg C, etal., Nat Genet 1998 Dec;20(4):401-4

Region

Strain QTL Data
Symbol Name Trait
Apr1 Acute phase response QTL 1 orosomucoid 1 amount   (VT:0010541)    
Apr2 Acute phase response QTL 2 blood murinoglobulin 1 amount   (VT:0010597)    
Apr3 Acute phase response QTL 3 blood interleukin-6 amount   (VT:0008595)    
Apr4 Acute phase response QTL 4 orosomucoid 1 amount   (VT:0010541)    
Apr5 Acute phase response QTL 5 blood interleukin-6 amount   (VT:0008595)    
Apr6 Acute phase response QTL 6 blood interleukin-6 amount   (VT:0008595)    
Eae1 Experimental allergic encephalomyelitis QTL 1 nervous system integrity trait   (VT:0010566)    
Eae10 Experimental allergic encephalomyelitis QTL 10 nervous system integrity trait   (VT:0010566)    
Eae11 Experimental allergic encephalomyelitis QTL 11 nervous system integrity trait   (VT:0010566)    
Eae5 Experimental allergic encephalomyelitis QTL 5 nervous system integrity trait   (VT:0010566)    
Eae6 Experimental allergic encephalomyelitis QTL 6 body mass   (VT:0001259)    
Eae7 Experimental allergic encephalomyelitis QTL 7 body mass   (VT:0001259)    
Eae8 Experimental allergic encephalomyelitis QTL 8 nervous system integrity trait   (VT:0010566)    
Eae9 Experimental allergic encephalomyelitis QTL 9 body mass   (VT:0001259)    
Eaex Experimental allergic encephalomyelitis QTL x nervous system integrity trait   (VT:0010566)    
Eaey Experimental allergic encephalomyelitis QTL y nervous system integrity trait   (VT:0010566)    
Eaez Experimental allergic encephalomyelitis QTL z nervous system integrity trait   (VT:0010566)    
Pia1 Pristane induced arthritis QTL 1 joint integrity trait   (VT:0010548)    
Pia11 Pristane induced arthritis QTL 11 joint integrity trait   (VT:0010548)    
Pia12 Pristane induced arthritis QTL 12 joint integrity trait   (VT:0010548)    
Pia13 Pristane induced arthritis QTL 13 joint integrity trait   (VT:0010548)    
Pia14 Pristane induced arthritis QTL 14 joint integrity trait   (VT:0010548)    
Pia2 Pristane induced arthritis QTL 2 joint integrity trait   (VT:0010548)    
Pia3 Pristane induced arthritis QTL 3 joint integrity trait   (VT:0010548)    
Pia4 Pristane induced arthritis QTL 4 joint integrity trait   (VT:0010548)    
Pia5 Pristane induced arthritis QTL 5 joint integrity trait   (VT:0010548)    
Pia6 Pristane induced arthritis QTL 6 joint integrity trait   (VT:0010548)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_life_disease Has platelet storage disease associated with the red-eyed yellow locus, as described by Raymond and Dodds (1975) for the FH strain. (Hedrich, unpublished). 1004
strain_life_disease Has platelet storage disease associated with the red-eyed yellow locus, as described by Raymond and Dodds (1975) for the FH strain. (Hedrich, unpublished). 634612
strain_life_disease These are relatively resistant to pristane induced arthritis. Mild and trasient arthritis is observed in 2 out of 23 animals. 61088