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Strain Registration

Strain: WF

Symbol: WF
Strain: WF
Full Name: Wistar Furth
RGD ID: 61007
Citation ID: RRID:RGD_61007
Ontology ID: RS:0000982
Also Known As: W/Fu
Type: inbred
Available Source: Not Available
Description: J Furth 1945 from a commercial Wistar stock in an attempt to develop a high leukaemia rat strain. Strain carries a distinctive heteropycnotic Y chromosome which may be used as a cellular marker (Zieverink and Moloney 1965). A substrain carrying the fuzzy mutation, which arose spontaneously in WF has been used in research on dermal toxicity, and is described in more detail by Marit et al, (1995).
Genetic Markers: c
Coat Color: Albino,
Inbred Generations: F?+58 (Pit).
Last Known Status: Unknown





References

References - curated
# Reference Title Reference Citation
1. Inbred Strains Festing, MFW, Inbred Strains, The Laboratory Rat, 1979, Baker HK, Lindsey JR, Weisbroth SH, 55-72, Academic Press
2. Update to previous Strain Data Festing, MFW, Personal Communication Update, Feb-2000
3. Genetic identification of Mcs-1, a rat mammary carcinoma suppressor gene. Hsu LC, etal., Cancer Res 1994 May 15;54(10):2765-70
4. Non-major histocompatibility complex-linked diabetes susceptibility loci on chromosomes 4 and 13 in a backcross of the DP-BB/Wor rat to the WF rat. Martin AM, etal., Diabetes 1999 Jan;48(1):50-8
5. RGD Strain RSO annotation pipeline RGD Automated Pipelines
6. Genetic identification of multiple loci that control breast cancer susceptibility in the rat Shepel LA, etal., Genetics 1998 May;149(1):289-99
7. p53 is a potential mediator of pregnancy and hormone-induced resistance to mammary carcinogenesis. Sivaraman L, etal., Proc Natl Acad Sci U S A 2001 Oct 23;98(22):12379-84.
8. Quantitative trait loci affecting 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in the rat. Tanuma J, etal., Cancer Res 1998 Apr 15;58(8):1660-4
9. Five quantitative trait loci affecting 4-nitroquinoline 1-oxide-induced tongue cancer in the rat. Tanuma JI, etal., Jpn J Cancer Res 2001 Jun;92(6):610-6.

Region

Strain QTL Data
Symbol Name Trait
Mcs1 Mammary carcinoma susceptibility QTL 1 mammary gland integrity trait   (VT:0010552)    
Mcs2 Mammary carcinoma susceptibility QTL 2 mammary gland integrity trait   (VT:0010552)    
Mcs3 Mammary carcinoma susceptibility QTL 3 mammary gland integrity trait   (VT:0010552)    
Mcs4 Mammary carcinoma susceptibility QTL 4 mammary gland integrity trait   (VT:0010552)    
Tcas1 Tongue tumor susceptibility QTL 1 tongue integrity trait   (VT:0010553)    
Tcas10 Tongue tumor susceptibility QTL 10 tongue integrity trait   (VT:0010553)    
Tcas2 Tongue tumor susceptibility QTL 2 tongue integrity trait   (VT:0010553)    
Tcas3 Tongue tumor susceptibility QTL 3 tongue integrity trait   (VT:0010553)    
Tcas4 Tongue tumor susceptibility QTL 4 tongue integrity trait   (VT:0010553)    
Tcas5 Tongue tumor susceptibility QTL 5 tongue integrity trait   (VT:0010553)    
Tcas6 Tongue tumor susceptibility QTL 6 tongue integrity trait   (VT:0010553)    
Tcas8 Tongue tumor susceptibility QTL 8 tongue integrity trait   (VT:0010553)    
Tcas9 Tongue tumor susceptibility QTL 9 tongue integrity trait   (VT:0010553)    
Tcat1 Tongue tumor resistance QTL 1 tongue integrity trait   (VT:0010553)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_drgs_chems Administration of 3-methylcholanthrene to young increased, but X-rays decreased leukaemia (Moloney et al 1969). Highly susceptibly to the induction of mammary cancer following exposure to dust of 7,12-dimethylbenz(a)-anthracene powder applied directly to exposed mammary tissue, in contrast with COP (Takahashi et al, 1992). Resistant (7/7) to the induction of squamous cell carcinomas of the tongue by 4-nitroquinoline 1-oxide (contrast DA) (Kitano et al, 1992). Sensitive to the convulsive effects of kainic acid (1/4) (Golden et al, 1995) 1004
strain_drgs_chems Administration of 3-methylcholanthrene to young increased, but X-rays decreased leukaemia (Moloney et al 1969). Highly susceptibly to the induction of mammary cancer following exposure to dust of 7,12-dimethylbenz(a)-anthracene powder applied directly to exposed mammary tissue, in contrast with COP (Takahashi et al, 1992). Resistant (7/7) to the induction of squamous cell carcinomas of the tongue by 4-nitroquinoline 1-oxide (contrast DA) (Kitano et al, 1992). Sensitive to the convulsive effects of kainic acid (1/4) (Golden et al, 1995) 634612
strain_life_disease Carcinoma of the colon found in 8/21 males and 8/29 females (Miyamoto and Takizawa 1975). In females tumours include 27% pituitary, 21% mammary, 3% adrenal, 9% leukaemia (generalised), 7% lymphoma (malignant), 3% lipomas and 4% unclassified (Kim et al 1960).Mean life span 21 months in females and 23 months in males. Leukaemia 15-22% characterised by an unusual type of mononuclear cell containing reddish granules. Incidence of spontaneous pituitary tumours 38% in rats older than 10 months of age, increasing to a maximum of 69% at 28-32 months of age. Higher incidence in females (71%) than in males (35%) (Trouillas et al1982). WF rats develop retinal dystrophy from about 3-months of age which resembles that found in RCS rats, but with a later onset. By about 7 months all rats are affected (Lin and Essner1988). Have an hereditary macrothromobcytopenia, with about 1/3rd. the normal number of platelets, which are larger than normal. The condition appears to be inherited as a recessiveMendelian character (Jackson et al 1986). 1004
strain_life_disease Carcinoma of the colon found in 8/21 males and 8/29 females (Miyamoto and Takizawa 1975). In females tumours include 27% pituitary, 21% mammary, 3% adrenal, 9% leukaemia (generalised), 7% lymphoma (malignant), 3% lipomas and 4% unclassified (Kim et al 1960).Mean life span 21 months in females and 23 months in males. Leukaemia 15-22% characterised by an unusual type of mononuclear cell containing reddish granules. Incidence of spontaneous pituitary tumours 38% in rats older than 10 months of age, increasing to a maximum of 69% at 28-32 months of age. Higher incidence in females (71%) than in males (35%) (Trouillas et al1982). WF rats develop retinal dystrophy from about 3-months of age which resembles that found in RCS rats, but with a later onset. By about 7 months all rats are affected (Lin and Essner1988). Have an hereditary macrothromobcytopenia, with about 1/3rd. the normal number of platelets, which are larger than normal. The condition appears to be inherited as a recessiveMendelian character (Jackson et al 1986). 634612
strain_phys_biochem Low serum growth hormone (5/5) (Esber et al 1974). Low blood pressure (20/23), reaching 123_1.3 (SEM) mmHg at 10 weeks of age (Tanase et al 1982). Resistant to adrenal regeneration hypertension (Molteni et al 1975). Increase in both the levels and nuclear accumulation of p53 in estrogen (E) and progesterone (P)-treated animals. Similar to E/P treatment, the pregnant- involuted mammary glands expressed higher levels of p53. The p21 protein is induced in the E/P-treated mammary glands upon carcinogen challenge. 1004
strain_phys_biochem Low serum growth hormone (5/5) (Esber et al 1974). Low blood pressure (20/23), reaching 123_1.3 (SEM) mmHg at 10 weeks of age (Tanase et al 1982). Resistant to adrenal regeneration hypertension (Molteni et al 1975). Increase in both the levels and nuclear accumulation of p53 in estrogen (E) and progesterone (P)-treated animals. Similar to E/P treatment, the pregnant- involuted mammary glands expressed higher levels of p53. The p21 protein is induced in the E/P-treated mammary glands upon carcinogen challenge. 634612