Strain Report - Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

Strain: LEW

Symbol: LEW
Strain: LEW
Full Name: Lewis
RGD ID: 60999
RRID: RGD_60999
Ontology ID: RS:0000121
Alleles: Tnfrsf1a;   Fgf2
Type: inbred
Source: Harlan Sprague Dawley Inc. Indianapolis, United States
Origin: Dr. Margaret Lewis from Wistar stock, to Aptekman and Bogden 1954 at F20, to Silvers in 1958 at F31. Subsequently distributed by Silvers. Used as the inbred partner for a number of congenic strains at the major histocompatibility complex (Stark and Kren 1969). A substrain with congenital hydrocephalus due to primary aqueductal stenosis has been described by Yamada et al, (1992)
Genetic Markers: a,h,c.
Coat Color: Albino
Inbred Generations: F?+96.
Last Known Status: Unknown





Disease Annotations     Click to see Annotation Detail View


References


Region

Strain QTL Data
Symbol Name Trait
Bmd1 Bone mineral density QTL 1 femur mineral mass   (VT:0010011)    
Bmd2 Bone mineral density QTL 2 lumbar vertebra area   (VT:0010570)    
Bmd3 Bone mineral density QTL 3 femur mineral mass   (VT:0010011)    
Bmd4 Bone mineral density QTL 4 lumbar vertebra mineral mass   (VT:0010511)    
Bmd5 Bone mineral density QTL 5 lumbar vertebra mineral mass   (VT:0010511)    
Bp168 Blood pressure QTL 168 blood pressure trait   (VT:0000183)    
Bp251 Blood pressure QTL 251 arterial blood pressure trait   (VT:2000000)    
Bp252 Blood pressure QTL 252 arterial blood pressure trait   (VT:2000000)    
Bp253 Blood pressure QTL 253 arterial blood pressure trait   (VT:2000000)    
Bp254 Blood pressure QTL 254 arterial blood pressure trait   (VT:2000000)    
Bp255 Blood pressure QTL 255 arterial blood pressure trait   (VT:2000000)    
Bp259 Blood pressure QTL 259 arterial blood pressure trait   (VT:2000000)    
Bp260 Blood pressure QTL 260 arterial blood pressure trait   (VT:2000000)    
Bp261 Blood pressure QTL 261 arterial blood pressure trait   (VT:2000000)    
Bp262 Blood pressure QTL 262 arterial blood pressure trait   (VT:2000000)    
Bp263 Blood pressure QTL 263 arterial blood pressure trait   (VT:2000000)    
Bp264 Blood pressure QTL 264 arterial blood pressure trait   (VT:2000000)    
Bp265 Blood pressure QTL 265 arterial blood pressure trait   (VT:2000000)    
Bp266 Blood pressure QTL 266 arterial blood pressure trait   (VT:2000000)    
Bp27 Blood pressure QTL 27 arterial blood pressure trait   (VT:2000000)    
Bp36 Blood pressure QTL 36 blood pressure trait   (VT:0000183)    
Bp37 Blood pressure QTL 37 blood pressure trait   (VT:0000183)    
Bp40 Blood pressure QTL 40 blood pressure trait   (VT:0000183)    
Bw112 Body weight QTL 112 body mass   (VT:0001259)    
Bw113 Body weight QTL 113 body mass   (VT:0001259)    
Bw114 Body weight QTL 114 body mass   (VT:0001259)    
Bw16 Body weight QTL 16 body mass   (VT:0001259)    
Bw47 Body weight QTL 47 body mass   (VT:0001259)    
Bw48 Body weight QTL 48 body mass   (VT:0001259)    
Bw49 Body weight QTL 49 body mass   (VT:0001259)    
Bw50 Body weight QTL 50 body mass   (VT:0001259)    
Bw51 Body weight QTL 51 body mass   (VT:0001259)    
Cari1 Carrageenan-induced inflammation QTL 1 hypodermis integrity trait   (VT:0010550)    
Cari2 Carrageenan-induced inflammation QTL 2 hypodermis integrity trait   (VT:0010550)    
Cm38 Cardiac mass QTL 38 heart mass   (VT:0007028)    
Cm39 Cardiac mass QTL 39 heart mass   (VT:0007028)    
Cm40 Cardiac mass QTL 40 heart mass   (VT:0007028)    
Cm41 Cardiac mass QTL 41 heart mass   (VT:0007028)    
Cm42 Cardiac mass QTL 42 heart mass   (VT:0007028)    
Eae2 Experimental allergic encephalomyelitis QTL 2 nervous system integrity trait   (VT:0010566)    
Eae3 Experimental allergic encephalomyelitis QTL 3 nervous system integrity trait   (VT:0010566)    
Eau1 Experimental allergic uveoretinitis QTL 1 uvea integrity trait   (VT:0010551)    
Eau2 Experimental allergic uveoretinitis QTL 2 uvea integrity trait   (VT:0010551)    
Eau3 Experimental allergic uveoretinitis QTL 3 uvea integrity trait   (VT:0010551)    
Iddm1 Insulin dependent diabetes mellitus QTL 1 blood glucose amount   (VT:0000188)    
Kidm22 Kidney mass QTL 22 kidney mass   (VT:0002707)    
Kidm23 Kidney mass QTL 23 kidney mass   (VT:0002707)    
Kidm24 Kidney mass QTL 24 kidney mass   (VT:0002707)    
Kidm25 Kidney mass QTL 25 kidney mass   (VT:0002707)    
Kidm26 Kidney mass QTL 26 kidney mass   (VT:0002707)    
Kidm27 Kidney mass QTL 27 kidney mass   (VT:0002707)    
Kidm28 Kidney mass QTL 28 kidney mass   (VT:0002707)    
Scl19 Serum cholesterol QTL 19 blood cholesterol amount   (VT:0000180)    
Scl20 Serum cholesterol level QTL 20 blood cholesterol amount   (VT:0000180)    
Scl21 Serum cholesterol level QTL 21 blood cholesterol amount   (VT:0000180)    
Scl33 Serum cholesterol QTL 33 blood cholesterol amount   (VT:0000180)    
Scl34 Serum cholesterol QTL 34 blood cholesterol amount   (VT:0000180)    
Scl35 Serum cholesterol QTL 35 blood cholesterol amount   (VT:0000180)    
Scl36 Serum cholesterol QTL 36 blood cholesterol amount   (VT:0000180)    
Scwia1 Streptococcal cell wall induced arthritis QTL 1 joint integrity trait   (VT:0010548)    
Stl25 Serum triglyceride level QTL 25 blood triglyceride amount   (VT:0002644)    
Stl26 Serum triglyceride level QTL 26 blood triglyceride amount   (VT:0002644)    
Stl27 Serum triglyceride level QTL 27 blood triglyceride amount   (VT:0002644)    
Stl28 Serum triglyceride level QTL 28 blood triglyceride amount   (VT:0002644)    
Stl29 Serum triglyceride level QTL 29 blood triglyceride amount   (VT:0002644)    
Stl30 Serum triglyceride level QTL 30 blood triglyceride amount   (VT:0002644)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_anatomy Low relative heart weight in 10-week old males (4/23) (Tanase et al 1982). 1004
strain_anatomy Low relative heart weight in 10-week old males (4/23) (Tanase et al 1982). 61059
strain_anatomy Low relative heart weight in 10-week old males (4/23) (Tanase et al 1982). 634612
strain_drgs_chems Long pentobarbitone sleeping time in males (3/10) but short time in females (10/10) (Vieregge et al 1987). High serum ceruloplasmin levels (Stolc 1984). Compared with F344, LEW rats show a much higher preference for several classes of drugs of abuse. This may be associated with lower levels of neurofilament proteins in the ventral tegmental area of the brain (Guitart et al, 1992). Duration of morphine-induced EEG slow-wave bursts and associated behavioural stupor was greater in LEW than F344 rats (Myomichelson and Young, 1993). LEW rats self-administer more morphine and drugs of abuse than F344 rats (Gosnell and Krahn, 1993, Glowa et al, 1994, Ambrosio et al, 1995). Duration of EEG slow-wave bursts and behavioural stupor also longer in LEW than F344 following administration of ethylketocyclazocine, suggesting differences in opioid-related receptor populations between these strains (Mayomichelson and Young, 1993). Cocaine conditioned place preference was greater in LEW than F344 rats (Kosten et al, 1994). Susceptible to the induction of glandular stomach adenocarcinomas following treatment with catechol (contrast WKY) (Tanaka et al, 1995). Rats were injected with N-methyl-N-nitrosourea (MNU) at 7 weeks of age; 2 weeks later, the rats were subjected to sustained treatment with 20 ug, 100 ug, 200 ug, or 30 ug of E (estradiol) in silastic capsules for 3 weeks. Treatments with 100 ug, 200 ug, or 30 ug of E resulted in serum levels of E equivalent to those of pregnancy and were highly effective in preventing mammary cancer. 1004
strain_drgs_chems Long pentobarbitone sleeping time in males (3/10) but short time in females (10/10) (Vieregge et al 1987). High serum ceruloplasmin levels (Stolc 1984). Compared with F344, LEW rats show a much higher preference for several classes of drugs of abuse. This may be associated with lower levels of neurofilament proteins in the ventral tegmental area of the brain (Guitart et al, 1992). Duration of morphine-induced EEG slow-wave bursts and associated behavioural stupor was greater in LEW than F344 rats (Myomichelson and Young, 1993). LEW rats self-administer more morphine and drugs of abuse than F344 rats (Gosnell and Krahn, 1993, Glowa et al, 1994, Ambrosio et al, 1995). Duration of EEG slow-wave bursts and behavioural stupor also longer in LEW than F344 following administration of ethylketocyclazocine, suggesting differences in opioid-related receptor populations between these strains (Mayomichelson and Young, 1993). Cocaine conditioned place preference was greater in LEW than F344 rats (Kosten et al, 1994). Susceptible to the induction of glandular stomach adenocarcinomas following treatment with catechol (contrast WKY) (Tanaka et al, 1995). Rats were injected with N-methyl-N-nitrosourea (MNU) at 7 weeks of age; 2 weeks later, the rats were subjected to sustained treatment with 20 ug, 100 ug, 200 ug, or 30 ug of E (estradiol) in silastic capsules for 3 weeks. Treatments with 100 ug, 200 ug, or 30 ug of E resulted in serum levels of E equivalent to those of pregnancy and were highly effective in preventing mammary cancer. 61059
strain_drgs_chems Long pentobarbitone sleeping time in males (3/10) but short time in females (10/10) (Vieregge et al 1987). High serum ceruloplasmin levels (Stolc 1984). Compared with F344, LEW rats show a much higher preference for several classes of drugs of abuse. This may be associated with lower levels of neurofilament proteins in the ventral tegmental area of the brain (Guitart et al, 1992). Duration of morphine-induced EEG slow-wave bursts and associated behavioural stupor was greater in LEW than F344 rats (Myomichelson and Young, 1993). LEW rats self-administer more morphine and drugs of abuse than F344 rats (Gosnell and Krahn, 1993, Glowa et al, 1994, Ambrosio et al, 1995). Duration of EEG slow-wave bursts and behavioural stupor also longer in LEW than F344 following administration of ethylketocyclazocine, suggesting differences in opioid-related receptor populations between these strains (Mayomichelson and Young, 1993). Cocaine conditioned place preference was greater in LEW than F344 rats (Kosten et al, 1994). Susceptible to the induction of glandular stomach adenocarcinomas following treatment with catechol (contrast WKY) (Tanaka et al, 1995). Rats were injected with N-methyl-N-nitrosourea (MNU) at 7 weeks of age; 2 weeks later, the rats were subjected to sustained treatment with 20 ug, 100 ug, 200 ug, or 30 ug of E (estradiol) in silastic capsules for 3 weeks. Treatments with 100 ug, 200 ug, or 30 ug of E resulted in serum levels of E equivalent to those of pregnancy and were highly effective in preventing mammary cancer. 634612
strain_infection Young animals susceptible to Borrelia burgdorferi-induced arthritic lesions resembling those found in human Lyme disease (Barthold et al 1988). Susceptible to the induction of encephalitis by coronavirus, with a much longer delay in lymphocyte proliferation following infection than in the resistant BN strain (Imrich et al, 1994). Susceptible (1/4) to ocular infection with herpes simplex virus with death following 4 x 104 plaque forming units (pfu). PVG was relatively resistant (Nicholls et al, 1994). 1004
strain_infection Young animals susceptible to Borrelia burgdorferi-induced arthritic lesions resembling those found in human Lyme disease (Barthold et al 1988). Susceptible to the induction of encephalitis by coronavirus, with a much longer delay in lymphocyte proliferation following infection than in the resistant BN strain (Imrich et al, 1994). Susceptible (1/4) to ocular infection with herpes simplex virus with death following 4 x 104 plaque forming units (pfu). PVG was relatively resistant (Nicholls et al, 1994). 61059
strain_infection Young animals susceptible to Borrelia burgdorferi-induced arthritic lesions resembling those found in human Lyme disease (Barthold et al 1988). Susceptible to the induction of encephalitis by coronavirus, with a much longer delay in lymphocyte proliferation following infection than in the resistant BN strain (Imrich et al, 1994). Susceptible (1/4) to ocular infection with herpes simplex virus with death following 4 x 104 plaque forming units (pfu). PVG was relatively resistant (Nicholls et al, 1994). 634612
strain_life_disease Survival 26% at 2 years (Lindsey et al 1968). In a study involving 305 female and 324 male rats of the LEW/Han substrain, mean lifespan in females was 27.7_5.1 months, in males 32.5_6.6 months. In both sexes the lifespan was mainly determined by the occurrence of neoplasms. Of the large spectrum of 52 histologically different types of tumours, the highest incidence was observed for adenomas of the pituitary and adenomas/adenocarcinomas of the adrenal cortex in both sexes, mammary gland tumours and endometrial carcinomas (45%) in females, and C-cell adenomas/adenocarcinomas of the thyroid gland and tumours of the haemopoietic system (28%) in males (Baum et al, 1995). [Immunology] Interferon production in response to polyriboinosinic-polyribocytodilic acid 20-40 fold higher than that observed in six other inbred strains. The effect is due to more than one gene, and is not associated with the MHC (Davis et al 1984). Resident macrophages (ramified microglea) of the central nervous system are not constitutively major histocompatibility complex class-II positive, in contrast with BN (Sedgwick et al, 1993). Mercury (HgCl2) stimulates peritoneal polymorphonuclear leukocytes and macrophages to produce hydrogen peroxide, in contrast with strain BN (Contrino et al, 1992). Resistant to the development of autoimmunity from skin-injected HgCl2 , in contrast to BN (Warfvinge and Larsson, 1994). Poor (5/5) antibody response to a synthetic 20 amino acid peptide derived from the alpha helical region of the RT1-D-u beta chain (Murphy et al, 1994). Although DA and LEW are both highly susceptible to the development of EAE, there are marked differences in the array of myelin epitopes capable of inducing the disease as well as MHC restriction of these epitopes between the two strains (Stepaniak et al, 1995). Highly susceptible to inflammatory disease due to deficient glucocorticoid counter-regulation of the immune response resulting from deficient corticotropin-releasing hormone responsiveness. Have significantly more benzodiazepine binding sites than F344, though there was no difference in affinities (Smith et al, 1992 see also Oitzl et al, 1995). No differences between LEW and F344 in the sensitivity of target tissues to exogenous glucocorticoids which could be associated with differences in susceptibility to inflammatory disease (Karalis et al, 1995). Short-term sustained treatments with pregnancy levels of E (estradiol) can induce protection against frank mammary cancer. 1004
strain_life_disease Survival 26% at 2 years (Lindsey et al 1968). In a study involving 305 female and 324 male rats of the LEW/Han substrain, mean lifespan in females was 27.7_5.1 months, in males 32.5_6.6 months. In both sexes the lifespan was mainly determined by the occurrence of neoplasms. Of the large spectrum of 52 histologically different types of tumours, the highest incidence was observed for adenomas of the pituitary and adenomas/adenocarcinomas of the adrenal cortex in both sexes, mammary gland tumours and endometrial carcinomas (45%) in females, and C-cell adenomas/adenocarcinomas of the thyroid gland and tumours of the haemopoietic system (28%) in males (Baum et al, 1995). [Immunology] Interferon production in response to polyriboinosinic-polyribocytodilic acid 20-40 fold higher than that observed in six other inbred strains. The effect is due to more than one gene, and is not associated with the MHC (Davis et al 1984). Resident macrophages (ramified microglea) of the central nervous system are not constitutively major histocompatibility complex class-II positive, in contrast with BN (Sedgwick et al, 1993). Mercury (HgCl2) stimulates peritoneal polymorphonuclear leukocytes and macrophages to produce hydrogen peroxide, in contrast with strain BN (Contrino et al, 1992). Resistant to the development of autoimmunity from skin-injected HgCl2 , in contrast to BN (Warfvinge and Larsson, 1994). Poor (5/5) antibody response to a synthetic 20 amino acid peptide derived from the alpha helical region of the RT1-D-u beta chain (Murphy et al, 1994). Although DA and LEW are both highly susceptible to the development of EAE, there are marked differences in the array of myelin epitopes capable of inducing the disease as well as MHC restriction of these epitopes between the two strains (Stepaniak et al, 1995). Highly susceptible to inflammatory disease due to deficient glucocorticoid counter-regulation of the immune response resulting from deficient corticotropin-releasing hormone responsiveness. Have significantly more benzodiazepine binding sites than F344, though there was no difference in affinities (Smith et al, 1992 see also Oitzl et al, 1995). No differences between LEW and F344 in the sensitivity of target tissues to exogenous glucocorticoids which could be associated with differences in susceptibility to inflammatory disease (Karalis et al, 1995). Short-term sustained treatments with pregnancy levels of E (estradiol) can induce protection against frank mammary cancer. 61059
strain_life_disease Survival 26% at 2 years (Lindsey et al 1968). In a study involving 305 female and 324 male rats of the LEW/Han substrain, mean lifespan in females was 27.7_5.1 months, in males 32.5_6.6 months. In both sexes the lifespan was mainly determined by the occurrence of neoplasms. Of the large spectrum of 52 histologically different types of tumours, the highest incidence was observed for adenomas of the pituitary and adenomas/adenocarcinomas of the adrenal cortex in both sexes, mammary gland tumours and endometrial carcinomas (45%) in females, and C-cell adenomas/adenocarcinomas of the thyroid gland and tumours of the haemopoietic system (28%) in males (Baum et al, 1995). [Immunology] Interferon production in response to polyriboinosinic-polyribocytodilic acid 20-40 fold higher than that observed in six other inbred strains. The effect is due to more than one gene, and is not associated with the MHC (Davis et al 1984). Resident macrophages (ramified microglea) of the central nervous system are not constitutively major histocompatibility complex class-II positive, in contrast with BN (Sedgwick et al, 1993). Mercury (HgCl2) stimulates peritoneal polymorphonuclear leukocytes and macrophages to produce hydrogen peroxide, in contrast with strain BN (Contrino et al, 1992). Resistant to the development of autoimmunity from skin-injected HgCl2 , in contrast to BN (Warfvinge and Larsson, 1994). Poor (5/5) antibody response to a synthetic 20 amino acid peptide derived from the alpha helical region of the RT1-D-u beta chain (Murphy et al, 1994). Although DA and LEW are both highly susceptible to the development of EAE, there are marked differences in the array of myelin epitopes capable of inducing the disease as well as MHC restriction of these epitopes between the two strains (Stepaniak et al, 1995). Highly susceptible to inflammatory disease due to deficient glucocorticoid counter-regulation of the immune response resulting from deficient corticotropin-releasing hormone responsiveness. Have significantly more benzodiazepine binding sites than F344, though there was no difference in affinities (Smith et al, 1992 see also Oitzl et al, 1995). No differences between LEW and F344 in the sensitivity of target tissues to exogenous glucocorticoids which could be associated with differences in susceptibility to inflammatory disease (Karalis et al, 1995). Short-term sustained treatments with pregnancy levels of E (estradiol) can induce protection against frank mammary cancer. 634612
strain_life_disease Recovery of cortonary flow rate was more than 60% of its ischemic value which is similar to WIST/Hsd and SS/JrHsdMcwi but less than DA/OlaHsd and BN/NHsdMcwi. 1342469
strain_phys_biochem High fertility. High serum thyroxine, insulin and growth hormone levels (1/5 in each case) (Esber et al 1974). Becomes obese on a high fat diet (rank 2/7)(Schemmel et al 1970). High hepatic metabolism of ethylmorphine in females (3/10) (Page and Vesell 1969). Short gestation period (3/8) (Peters 1986). Low blood pressure (22/23), reaching 119_2.0 (SEM) mmHg at 10 weeks of age (Tanase et al 1982). Liver gangliosides are of the a-type (cf ACI, LEA, & BUF) (Kasai et al 1993). Rapid metaboliser of MPPB (F344 is slow) (Takahara et al 1993). Have substantially lower levels of diurnal and stress related corticosterone levels with higher levels of corticosteroid-binding globulin in plasma, spleen and thymus than F344 rats (Dhabhar et al, 1993). Lower concentrations of cortical and hippocampal 5-HT1A receptors compared with F344 and outbred Spargue-Dalwey rats (Burnet et al, 1994). Hackbarth et al (1981) report on kidney function in this and other strains. Hackbarth et al (1983) report on haematological parameters in relation to several other strains. 1004
strain_phys_biochem High fertility. High serum thyroxine, insulin and growth hormone levels (1/5 in each case) (Esber et al 1974). Becomes obese on a high fat diet (rank 2/7)(Schemmel et al 1970). High hepatic metabolism of ethylmorphine in females (3/10) (Page and Vesell 1969). Short gestation period (3/8) (Peters 1986). Low blood pressure (22/23), reaching 119_2.0 (SEM) mmHg at 10 weeks of age (Tanase et al 1982). Liver gangliosides are of the a-type (cf ACI, LEA, & BUF) (Kasai et al 1993). Rapid metaboliser of MPPB (F344 is slow) (Takahara et al 1993). Have substantially lower levels of diurnal and stress related corticosterone levels with higher levels of corticosteroid-binding globulin in plasma, spleen and thymus than F344 rats (Dhabhar et al, 1993). Lower concentrations of cortical and hippocampal 5-HT1A receptors compared with F344 and outbred Spargue-Dalwey rats (Burnet et al, 1994). Hackbarth et al (1981) report on kidney function in this and other strains. Hackbarth et al (1983) report on haematological parameters in relation to several other strains. 61059
strain_phys_biochem High fertility. High serum thyroxine, insulin and growth hormone levels (1/5 in each case) (Esber et al 1974). Becomes obese on a high fat diet (rank 2/7)(Schemmel et al 1970). High hepatic metabolism of ethylmorphine in females (3/10) (Page and Vesell 1969). Short gestation period (3/8) (Peters 1986). Low blood pressure (22/23), reaching 119_2.0 (SEM) mmHg at 10 weeks of age (Tanase et al 1982). Liver gangliosides are of the a-type (cf ACI, LEA, & BUF) (Kasai et al 1993). Rapid metaboliser of MPPB (F344 is slow) (Takahara et al 1993). Have substantially lower levels of diurnal and stress related corticosterone levels with higher levels of corticosteroid-binding globulin in plasma, spleen and thymus than F344 rats (Dhabhar et al, 1993). Lower concentrations of cortical and hippocampal 5-HT1A receptors compared with F344 and outbred Spargue-Dalwey rats (Burnet et al, 1994). Hackbarth et al (1981) report on kidney function in this and other strains. Hackbarth et al (1983) report on haematological parameters in relation to several other strains. 634612