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Strain: LOU/M

Symbol: LOU/M
Strain: LOU
Substrain: M
RGD ID: 60988
Citation ID: RRID:RGD_60988
Ontology ID: RS:0000566
Type: inbred
Available Source: Not Available
Description: Bazin and Beckers from rats of presumed Wistar origin kept at the Universite Catholique de Louvain. LOU/C was selected among 28 parallel sublines for its high incidence of plasmacytomas, and LOU/M for its low incidence. The two are histocomaptible. Histocompatible with LOU/C and maintained by selection of LOU/M males on the basis of acceptance of skin grafts from LOU/C rats (Bazin 1977, Beckers and Bazin 1978).
Genetic Markers: c
Coat Color: Albino.
Inbred Generations: F?+36.
Last Known Status: Unknown





Phenotype Values via Phenominer Click to see Annotation Detail View

Related Phenotype Data for Term "LOU/M" (RS:0000566)

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References

References - curated
# Reference Title Reference Citation
1. Studies on the incidence of rat ileocecal malignant immunocytoma: vertical transmission of the high tumour incidence. Bazin H, etal., Cancer Lett. 1980 Feb;8(4):353-7. doi: 10.1016/0304-3835(80)90152-4.
2. Antitumor activity, induction of cross-resistance, and nephrotoxicity of a new platinum analogue, cis-1,1-diaminomethylcyclohexaneplatinum(II) sulfate, and of cis-diamminedichloroplatinum(II) in an immunocytoma model in the LOU/M rat. de Jong WH, etal., Cancer Res. 1983 Oct;43(10):4927-34.
3. Inbred Strains Festing, MFW, Inbred Strains, The Laboratory Rat, 1979, Baker HK, Lindsey JR, Weisbroth SH, 55-72, Academic Press
4. Update to previous Strain Data Festing, MFW, Personal Communication Update, Feb-2000
5. T cell lines specific for an immunodominant epitope of human basic protein define an encephalitogenic determinant for experimental autoimmune encephalomyelitis-resistant LOU/M rats. Hashim G, etal., J Immunol. 1991 Jan 15;146(2):515-20.
6. Localization of genetic loci controlling hydronephrosis in the Brown Norway rat and its association with hematuria. Kota L, etal., Physiol Genomics. 2008 Jul 15;34(2):215-24. Epub 2008 Jun 3.
7. RGD Strain RSO annotation pipeline RGD Automated Pipelines
8. Reduced cardiotoxicity and nephrotoxicity with preservation of antitumor activity of doxorubicin entrapped in stable liposomes in the LOU/M Wsl rat. van Hoesel QG, etal., Cancer Res. 1984 Sep;44(9):3698-705.
9. Antitumor effect, cardiotoxicity, and nephrotoxicity of doxorubicin in the IgM solid immunocytoma-bearing LOU/M/WSL rat. van Hoesel QG, etal., J Natl Cancer Inst. 1984 May;72(5):1141-50.
10. Time-course study on doxorubicin-induced nephropathy and cardiomyopathy in male and female LOU/M/Wsl rats: lack of evidence for a causal relationship. van Hoesel QG, etal., J Natl Cancer Inst. 1986 Feb;76(2):299-307.
11. Functional analysis of a T cell line specific for antiidiotypic antibodies to a Schistosoma mansoni protective epitope. II. Induction of protective immunity in experimental rat schistosomiasis. Velge-Roussel F, etal., J Immunol. 1991 Dec 1;147(11):3967-72.
12. Functional properties of a rat monoclonal IgE antibody specific for Schistosoma mansoni. Verwaerde C, etal., J Immunol. 1987 Jun 15;138(12):4441-6.

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics Good antibody response to ovalbumin with Bordetella pertussis organisms as adjuvent (Bazinand Platteau 1976). Susceptible to the development of cerebral malaria when inoculated withPlasmodium berghei ANKA (Neill 1991) 1004
strain_characteristics Good antibody response to ovalbumin with Bordetella pertussis organisms as adjuvent (Bazinand Platteau 1976). Susceptible to the development of cerebral malaria when inoculated withPlasmodium berghei ANKA (Neill 1991) 634612