| Note Type |
Note |
Reference |
| strain_drgs_chems |
Transplantable Morris hepatomas have been induced by several chemical agents (Morris and Wagner 1968, Morris et al 1970, Morris and Slaughter 1979). 2-acetylaminofluorine induces liver tumours in 10% of female and 70% of males and mammary tumours in 70% of females (Symeonidis 1954). Low hepatic metabolism of ethylmorphine (7/10 in males 10/10 in females), but high metabolism of anilene (3/10 males, 1/10 females) (Page and Vesell 1969). Resistant to the induction of gastric tumours by N-methyl-N-nitro- N-nitrosoguanidine (Ohgaki et al 1983). Resistant to tumour induction by 3-methylcholanthrene, 7,12-dimethylbenz(a)anthracene and trypan blue, though the former two and Bordetella pertussis vaccine induce chronic thyroiditis (Reuber and Glover1969, 1976). Resistant to the development of N-methyl-N-nitrosoguanidine (MNNG) induced gastric cancer though levels of adduct were same as in the susceptible ACI strain (Sugimura et al1995). |
1004
|
| strain_drgs_chems |
Transplantable Morris hepatomas have been induced by several chemical agents (Morris and Wagner 1968, Morris et al 1970, Morris and Slaughter 1979). 2-acetylaminofluorine induces liver tumours in 10% of female and 70% of males and mammary tumours in 70% of females (Symeonidis 1954). Low hepatic metabolism of ethylmorphine (7/10 in males 10/10 in females), but high metabolism of anilene (3/10 males, 1/10 females) (Page and Vesell 1969). Resistant to the induction of gastric tumours by N-methyl-N-nitro- N-nitrosoguanidine (Ohgaki et al 1983). Resistant to tumour induction by 3-methylcholanthrene, 7,12-dimethylbenz(a)anthracene and trypan blue, though the former two and Bordetella pertussis vaccine induce chronic thyroiditis (Reuber and Glover1969, 1976). Resistant to the development of N-methyl-N-nitrosoguanidine (MNNG) induced gastric cancer though levels of adduct were same as in the susceptible ACI strain (Sugimura et al1995). |
634612
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| strain_immunology |
Autoimmune thyroiditis seen in 6/11 males at 36 weeks of age, but not seen in five other strains (Hajdu and Rona 1969). Spontaneous autoimmune thyroiditis with mononucelear cell infiltration of the thyroid in 26% of animals over one year (Noble et al 1976). Autoimmune thyroiditis develops spontaneously and after the ingestion of 3-methylcolanthrene, but reaches nearly 100% after neonatal thymectomy (Silverman and Rose 1975a,b). Autoimmune thyroiditis is exacerbated by high iodine diet (Cohen and Weetman 1988). Poor immune response to sheep red blood cells(6/7) (Tada et al 1974). Epitope specificities of collagen-induced studied by Cremer et al (1992).Relatively resistant to the induction of autologous immune complex nephritis (Klassen et al 1971).Poor immune response to sheep red blood cells (Tada et al 1974). A synthetic polypeptide corresponding to residues 87-99 of myelin basic protein is antigenic and encephalitogenic in these rats (Jones et al, 1992). Susceptible to the induction of EAU by interphotoreceptor retinol-binding protein (cf WKAH, W/M, LEJ and LEW, but in contrast with TO) (Sasamoto et al, 1994). Susceptible to the induction of relapsing experimental autoimmune encephalomyelitis (an animalmodel of multiple sclerosis), which can be successfully treated by an allogeneic bone marrow transplant (Van Gelder and Van Bekkum, 1995). |
1004
|
| strain_immunology |
Autoimmune thyroiditis seen in 6/11 males at 36 weeks of age, but not seen in five other strains (Hajdu and Rona 1969). Spontaneous autoimmune thyroiditis with mononucelear cell infiltration of the thyroid in 26% of animals over one year (Noble et al 1976). Autoimmune thyroiditis develops spontaneously and after the ingestion of 3-methylcolanthrene, but reaches nearly 100% after neonatal thymectomy (Silverman and Rose 1975a,b). Autoimmune thyroiditis is exacerbated by high iodine diet (Cohen and Weetman 1988). Poor immune response to sheep red blood cells(6/7) (Tada et al 1974). Epitope specificities of collagen-induced studied by Cremer et al (1992).Relatively resistant to the induction of autologous immune complex nephritis (Klassen et al 1971).Poor immune response to sheep red blood cells (Tada et al 1974). A synthetic polypeptide corresponding to residues 87-99 of myelin basic protein is antigenic and encephalitogenic in these rats (Jones et al, 1992). Susceptible to the induction of EAU by interphotoreceptor retinol-binding protein (cf WKAH, W/M, LEJ and LEW, but in contrast with TO) (Sasamoto et al, 1994). Susceptible to the induction of relapsing experimental autoimmune encephalomyelitis (an animalmodel of multiple sclerosis), which can be successfully treated by an allogeneic bone marrow transplant (Van Gelder and Van Bekkum, 1995). |
634612
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| strain_infection |
Rapid elimination of Trichinella spiralis worms (1/12) (Bell, 1992) |
1004
|
| strain_infection |
Rapid elimination of Trichinella spiralis worms (1/12) (Bell, 1992) |
634612
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| strain_life_disease |
Low incidence of dental caries. Spontaneous tumours of anterior pituitary 30%, and of adrenalcortex 25% in older animals. Survival 58% at 2 years of age with thyroid carcinoma in 25% (Lindsey et al 1968). Low incidence of renal neoplasms (Snell 1967). High incidence of tumours of the anterior pituitary, adrenal medulla and adrenal cortex in animals over 18 months old (Snell1965). In one line, BUF/Mna, thymomas occur spontaneously in 100% of males and 98% of females more than 18 months of age (Matasuyama et al 1986). Susceptibility appears to be dueto a single autosomal dominant locus, Tsr-1. However, this line was reported to have been independently inbred from outbred stock so may be genetically distinct from other BUF substrains (Matsuyama et al 1988). Thymoma development appears to be due to an intrinsic abnormality of the thymic epithelium as thymus rudiments transplanted to nude rats also develop similar lesions (Taguchi et al, 1992). Abnormal proliferation signals to the thymic macrophages and/or their progenitor cells may be involved in the development of thymomas (Masuda et al 1992). At the pre-thymoma stage BUF rats have extremely large thymuses due to a gene Ten-1 located on chromosome 1. This gene may be identical to Tsr-1 (Murakumo et al, 1993, 1995). High incidence of prenatal mortality (1/8=18%) early and (2/11=11%) late, but no congenital abnormalities detected (Shoji 1977). |
1004
|
| strain_life_disease |
Low incidence of dental caries. Spontaneous tumours of anterior pituitary 30%, and of adrenalcortex 25% in older animals. Survival 58% at 2 years of age with thyroid carcinoma in 25% (Lindsey et al 1968). Low incidence of renal neoplasms (Snell 1967). High incidence of tumours of the anterior pituitary, adrenal medulla and adrenal cortex in animals over 18 months old (Snell1965). In one line, BUF/Mna, thymomas occur spontaneously in 100% of males and 98% of females more than 18 months of age (Matasuyama et al 1986). Susceptibility appears to be dueto a single autosomal dominant locus, Tsr-1. However, this line was reported to have been independently inbred from outbred stock so may be genetically distinct from other BUF substrains (Matsuyama et al 1988). Thymoma development appears to be due to an intrinsic abnormality of the thymic epithelium as thymus rudiments transplanted to nude rats also develop similar lesions (Taguchi et al, 1992). Abnormal proliferation signals to the thymic macrophages and/or their progenitor cells may be involved in the development of thymomas (Masuda et al 1992). At the pre-thymoma stage BUF rats have extremely large thymuses due to a gene Ten-1 located on chromosome 1. This gene may be identical to Tsr-1 (Murakumo et al, 1993, 1995). High incidence of prenatal mortality (1/8=18%) early and (2/11=11%) late, but no congenital abnormalities detected (Shoji 1977). |
634612
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| strain_phys_biochem |
Liver gangliosides are of the a-type (cf ACI, LEA & LEW) (Kasai et al 1993).High 10-week body weight in males (23/23) (Tanase et al 1982). |
1004
|
| strain_phys_biochem |
Liver gangliosides are of the a-type (cf ACI, LEA & LEW) (Kasai et al 1993).High 10-week body weight in males (23/23) (Tanase et al 1982). |
634612
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| strain_reproduction |
Intermediate breeding performance (5/12) and litter size (8/12) (Hansen et al 1973). |
1004
|
| strain_reproduction |
Intermediate breeding performance (5/12) and litter size (8/12) (Hansen et al 1973). |
634612
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