Strain Report - Rat Genome Database

Name: SS- Nox4 em2Mcwi-/-
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Strain Registration

General

Strain: SS-Nox4^em2Mcwi-/-

Symbol:

SS-Nox4^em2Mcwi-/-

Strain:

SS-Nox4^em2-/Nox4^em2-

Substrain:

Mcwi

Full Name:

SS-Nox4^em2Mcwi-/Nox4^em2Mcwi-

RGD ID:

5688074

Citation ID:

RRID:RGD_5688074

Ontology ID:

RS:0003150

Alleles:

Nox4^em2Mcwi

Previously known as:

SS-Nox4em2Mcwi-/-; SS-Nox4em2Mcwi/1Mcwi; SS-Nox4^em2Mcwi/1Mcwi; SS-Nox4em2Mcwi-/Nox4em2Mcwi-

Type:

mutant

Source:

PhysGen Knockouts

Origin:

ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. This homozygous mutant carries an 8-bp frameshift deletion in exon 7 of rat Nox4.

Genetic Status:

Homozygous

Last Known Status:

Live Animals; Cryopreserved Sperm (as of 2019-01-03)

Position

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	140,900,886 - 141,078,844	RGD_MAPPER_PIPELINE	mRatBN7.2
Rnor_6.0	1	150,796,359 - 150,976,186	RGD_MAPPER_PIPELINE	Rnor6.0
Rnor_5.0	1	157,106,652 - 157,285,107	RGD_MAPPER_PIPELINE	Rnor5.0
RGSC_v3.4	1	143,415,816 - 143,603,554	RGD_MAPPER_PIPELINE	RGSC3.4

Annotation Click to see Annotation Detail View

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

decreased mean systemic arterial blood pressure (IMP)

decreased susceptibility to hypertension (IMP)

decreased urine albumin level (IMP)

oxidative stress (IMP)

Phenotype Values via PhenoMiner Click to see Annotation Detail View

Options:

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Clinical Measurement

heart rate

mean arterial blood pressure

body weight

heart wet weight

right kidney wet weight

left kidney wet weight

urine total protein excretion rate

urine albumin excretion rate

urine sodium excretion rate

urine creatinine excretion rate

References

References - curated

#	Reference Title	Reference Citation
1.	Evidence of the Importance of Nox4 in Production of Hypertension in Dahl Salt-Sensitive Rats.	Cowley AW Jr, etal., Hypertension. 2016 Feb;67(2):440-50. doi: 10.1161/HYPERTENSIONAHA.115.06280. Epub 2015 Dec 7.
2.	Knockout rats via embryo microinjection of zinc-finger nucleases.	Geurts AM, etal., Science. 2009 Jul 24;325(5939):433.
3.	PhysGen Knockouts	PhysGen Knockout strains
4.	RGD Strain RSO annotation pipeline	RGD Automated Pipelines

Region

Additional Information

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2014-03-31	SS-Nox4^em2Mcwi-/-	SS-Nox4^em2Mcwi-/Nox4^em2Mcwi-	SS-Nox4^em2Mcwi-/-	SS-Nox4^em2Mcwi-/Nox4^em2Mcwi-	Symbol and/or name change	68913	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Strain: SS-Nox4em2Mcwi-/-

Mammalian Phenotype

Related Phenotype Data for Term "SS-Nox4em2Mcwi-/-" (RS:0003150)

Strain: SS-Nox4^em2Mcwi-/-