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Strain: SS-Ets1em1Mcwi-/+

Symbol: SS-Ets1em1Mcwi-/+
Strain: SS-Ets1em1-/Ets1em1+
Substrain: Mcwi
Full Name: SS-Ets1em1Mcwi-/Ets1em1Mcwi+
RGD ID: 5688010
Citation ID: RRID:RGD_5688010
Ontology ID: RS:0003126
Alleles: Ets1em1Mcwi
Also Known As: SS-Ets1em1Mcwi-/+; SS-Ets1em1Mcwi/2Mcwi; SS-Ets1em1Mcwi/2Mcwi; SS-Ets1em1Mcwi-/Est1em1Mcwi+; SS-Ets1^[em1Mcwi-/+]
Type: mutant
Available Source: Not Available
Origination: PhysGen Knockouts
Description: ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders.
Genetic Status: Heterozygous
Last Known Status: Cryopreserved Sperm (as of 2018-09-05)
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2831,045,909 - 31,168,010RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0833,851,478 - 33,851,485RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0833,798,598 - 33,921,593RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.4832,481,694 - 32,545,237RGD_MAPPER_PIPELINERGSC3.4


References - curated
# Reference Title Reference Citation
1. Haploinsufficiency of the Transcription Factor Ets-1 Is Renoprotective in Dahl Salt-Sensitive Rats. Feng W, etal., J Am Soc Nephrol. 2017 Nov;28(11):3239-3250. doi: 10.1681/ASN.2017010085. Epub 2017 Jul 10.
2. Avian erythroblastosis virus E26 oncogene homolog-1 (ETS-1) plays a role in renal microvascular pathophysiology in the Dahl salt-sensitive rat. Feng W, etal., Kidney Int. 2020 Mar;97(3):528-537. doi: 10.1016/j.kint.2019.09.025. Epub 2019 Oct 22.
3. Knockout rats via embryo microinjection of zinc-finger nucleases. Geurts AM, etal., Science. 2009 Jul 24;325(5939):433.
4. PhysGen Knockouts PhysGen Knockout strains
5. RGD Strain RSO annotation pipeline RGD Automated Pipelines


Additional Information

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-03-31 SS-Ets1em1Mcwi-/+  SS-Ets1em1Mcwi-/Ets1em1Mcwi+  SS-Ets1em1Mcwi-/+  SS-Ets1em1Mcwi-/Ets1em1Mcwi+  Symbol and/or name change 68913 APPROVED
2012-02-16 SS-Ets1em1Mcwi-/+  SS-Ets1em1Mcwi-/Ets1em1Mcwi+  SS-Ets1em1Mcwi-/+  SS-Ets1em1Mcwi-/Ets1em1Mcwi+  Name updated 68913 APPROVED