Strain Report - Rat Genome Database

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Strain: ACI.FHH-(D1Mit18-D1Rat90)(D3Got102-D3Got149)(D14Mit11-D14Rat33)(D14Rat65-D14Rat90)/Mcwi

Symbol: ACI.FHH-(D1Mit18-D1Rat90)(D3Got102-D3Got149)(D14Mit11-D14Rat33)(D14Rat65-D14Rat90)/Mcwi
Strain: ACI.FHH-(D1Mit18-D1Rat90)(D3Got102-D3Got149)(D14Mit11-D14Rat33)(D14Rat65-D14Rat90)
Substrain: Mcwi
RGD ID: 5686832
Citation ID: RRID:RGD_5686832
Ontology ID: RS:0003110
Also Known As: ACI.FHH-(D1Mit18-D1Rat90)(D3Got102-D3Got149)(D14Mit11-D14Rat33)(D14Rat65-D14Rat90)/Mcwi; ACI.FHH-(D1Mit18-D1Rat90)(D3Got102-D3Got149)(D14Mit11-D14Rat33/D14Rat65-D14Rat90)/Mcwi; Rf-1+3+4_b; Rf-1A+3+4_b
Type: congenic
Available Source: Not Available
Origination: Medical College of Wisconsin, Milwaukee, Wisconsin
Description: Multicongenic strain which was generated using the speed congenic strategy by backcrossing ACI.FHH-(D1Mit18-D1Rat90)(D3Rat84-D3Rat59)(D14Mit11-D14Rat33)(D14Rat65-D14Rat90)/Eur and ACI.FHH-(D1Mit18-D1Rat90)(D14Mit11-D14Rat33)(D14Rat65-D14Rat90)/EurMcwi.
Last Known Status: Unknown





Disease Annotations     Click to see Annotation Detail View
Albuminuria  (IAGP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. Refined mapping of the renal failure RF-3 quantitative trait locus. O'Meara CC, etal., J Am Soc Nephrol. 2011 Mar;22(3):518-25. Epub 2010 Dec 2.
2. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region

Strain QTL Data
Symbol Name Trait
Rf59 Renal function QTL 59 urine albumin amount   (VT:0002871)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_other increased focal segmental glomerular sclerosis, focal tubular interstitial fibrosis and tubular atrophy was seen in the kidney sections 5684423
strain_phys_biochem increased albumin excretion after unilateral nephrectomy as compared to ACI.FHH-(D1Mit18-D1Rat90)(D3Rat6-D3Got149)(D14Mit11-D14Rat33)(D14Rat65-D14Rat90)/Mcwi (Rf-1+3+4_a) at 9 weeks of age and also ACI.FHH-(D1Mit18-D1Rat90)(D14Mit11-D14Rat33)(D14Rat65-D14Rat90)/EurMcwi (Rf-1+4) 5684423
strain_phys_biochem slight increase in MAP as compared to ACI.FHH-(D1Mit18-D1Rat90)(D3Rat6-D3Got149)(D14Mit11-D14Rat33)(D14Rat65-D14Rat90)/Mcwi (Rf-1+3+4_a) at 9 weeks of age and also ACI.FHH-(D1Mit18-D1Rat90)(D14Mit11-D14Rat33)(D14Rat65-D14Rat90)/EurMcwi (Rf-1+4) 5684423