Strain Report - Rat Genome Database

Name: SS- Plekha7 em4Mcwi-/-
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Strain Registration

General

Strain: SS-Plekha7^em4Mcwi-/-

Symbol:

SS-Plekha7^em4Mcwi-/-

Strain:

SS-Plekha7^em4-/Plekha7^em4-

Substrain:

Mcwi

Full Name:

SS-Plekha7^em4Mcwi-/Plekha7^em4Mcwi-

RGD ID:

5686758

Citation ID:

RRID:RGD_5686758

Ontology ID:

RS:0003088

Alleles:

Plekha7^em4Mcwi

Previously known as:

SS-Plekha7em4Mcwi-/-; SS-Plekha7em4Mcwi/1Mcwi; SS-Plekha7^em4Mcwi/1Mcwi; SS-Plekha7em4Mcwi-/Plekha7em4Mcwi-

Type:

mutant

Source:

PhysGen Knockouts

Origin:

ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders.

Genetic Status:

Homozygous

Last Known Status:

Live Animals; Cryopreserved Sperm (as of 2018-09-05)

Position

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	170,364,524 - 170,547,843	RGD_MAPPER_PIPELINE	mRatBN7.2
Rnor_6.0	1	185,427,600 - 185,493,985	RGD_MAPPER_PIPELINE	Rnor6.0
Rnor_5.0	1	192,397,589 - 192,463,974	RGD_MAPPER_PIPELINE	Rnor5.0
RGSC_v3.4	1	174,249,022 - 174,316,226	RGD_MAPPER_PIPELINE	RGSC3.4

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Cardiac Fibrosis (IMP)

glomerulosclerosis (IMP)

hypertension (IMP)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

decreased susceptibility to hypertension (IMP)

decreased systemic vascular resistance (IMP)

decreased urine albumin level (IMP)

decreased urine protein level (IMP)

increased cardiac output (IMP)

increased cardiac stroke volume (IMP)

increased vasodilation (IMP)

salt-sensitive hypertension (IMP)

Phenotype Values via PhenoMiner Click to see Annotation Detail View

Options:

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Download data table

View expanded data table

References

References - curated

#	Reference Title	Reference Citation
1.	Mutation of Plekha7 attenuates salt-sensitive hypertension in the rat.	Endres BT, etal., Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12817-22. doi: 10.1073/pnas.1410745111. Epub 2014 Aug 18.
2.	Knockout rats via embryo microinjection of zinc-finger nucleases.	Geurts AM, etal., Science. 2009 Jul 24;325(5939):433.
3.	PhysGen Knockouts	PhysGen Knockout strains
4.	RGD Strain RSO annotation pipeline	RGD Automated Pipelines

Region

Additional Information

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2014-03-27	SS-Plekha7^em4Mcwi-/-	SS-Plekha7^em4Mcwi-/Plekha7^em4Mcwi-	SS-Plekha7^em4Mcwi-/-	SS-Plekha7^em4Mcwi-/Plekha7^em4Mcwi-	Symbol and/or name change	68913	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Strain: SS-Plekha7em4Mcwi-/-

Mammalian Phenotype

Related Phenotype Data for Term "SS-Plekha7em4Mcwi-/-" (RS:0003088)

Strain: SS-Plekha7^em4Mcwi-/-