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Strain Registration

Strain: SS-Nppbem2Mcwi-/-

Symbol: SS-Nppbem2Mcwi-/-
Strain: SS-Nppbem2-/Nppbem2-
Substrain: Mcwi
Full Name: SS-Nppbem2Mcwi-/Nppbem2Mcwi-
RGD ID: 5686730
Citation ID: RRID:RGD_5686730
Ontology ID: RS:0003075
Alleles: Nppbem2Mcwi
Also Known As: SS-Nppbem2Mcwi-/-; SS-Nppbem2Mcwi/1Mcwi; SS-Nppbem2Mcwi/1Mcwi; SS-Nppbem2Mcwi-/Nppbem2Mcwi-; SS-Nppb^[em2Mcwi-/-]
Type: mutant
Available Source: Not Available
Origination: PhysGen Knockouts
Description: ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders.
Genetic Status: Homozygous
Last Known Status: Unknown
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr85163,699,955 - 163,701,314RGD_MAPPER_PIPELINE
mRatBN7.25158,416,813 - 158,418,175RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.05164,796,229 - 164,797,531RGD_MAPPER_PIPELINERnor6.0
Rnor_5.05168,454,278 - 168,455,640RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.45165,062,348 - 165,063,650RGD_MAPPER_PIPELINERGSC3.4





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Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. Knockout rats via embryo microinjection of zinc-finger nucleases. Geurts AM, etal., Science. 2009 Jul 24;325(5939):433.
2. B-Type Natriuretic Peptide Deletion Leads to Progressive Hypertension, Associated Organ Damage, and Reduced Survival: Novel Model for Human Hypertension. Holditch SJ, etal., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11.
3. PhysGen Knockouts PhysGen Knockout strains
4. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-16 SS-Nppbem2Mcwi-/-  SS-Nppbem2Mcwi-/Nppbem2Mcwi-  SS-Nppbem2Mcwi-/-  SS-Nppbem2Mcwi-/Nppbem2Mcwi-  Symbol and/or name change 68913 APPROVED