Strain Report - Rat Genome Database

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Strain: SS-Sh2b3em1Mcwi-/-

Symbol: SS-Sh2b3em1Mcwi-/-
Strain: SS-Sh2b3em1-/Sh2b3em1-
Substrain: Mcwi
Full Name: SS-Sh2b3em1Mcwi-/Sh2b3em1Mcwi-
RGD ID: 5686318
Citation ID: RRID:RGD_5686318
Ontology ID: RS:0003024
Alleles: Sh2b3em1Mcwi
Previously known as: SS-Sh2b3em1Mcwi-/-; SS-Sh2b3em1Mcwi/1Mcwi; SS-Sh2b3em1Mcwi/1Mcwi; SS-Sh2b3em1Mcwi-/Sh2b3em1Mcwi-
Type: mutant
Source: PhysGen Knockouts
Origin: ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. The resulting mutation is an in-frame 6-bp deletion in exon 2 .
Genetic Status: Homozygous
Last Known Status: Cryopreserved Sperm (as of 2021-11-03)
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21234,749,849 - 34,753,616RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01240,261,990 - 40,265,757RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01242,132,947 - 42,136,714RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41235,954,679 - 35,958,446RGD_MAPPER_PIPELINERGSC3.4


References - curated
# Reference Title Reference Citation
1. Knockout rats via embryo microinjection of zinc-finger nucleases. Geurts AM, etal., Science. 2009 Jul 24;325(5939):433.
2. PhysGen Knockouts PhysGen Knockout strains
3. RGD Strain RSO annotation pipeline RGD Automated Pipelines
4. Mutation of SH2B3 (LNK), a genome-wide association study candidate for hypertension, attenuates Dahl salt-sensitive hypertension via inflammatory modulation. Rudemiller NP, etal., Hypertension. 2015 May;65(5):1111-7. doi: 10.1161/HYPERTENSIONAHA.114.04736. Epub 2015 Mar 16.


Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Sh2b3em1Mcwi-var1 chr12 34750772 34750777 CACTTG - deletion mRatBN7.2
Sh2b3em1Mcwi-var1 chr12 40262913 40262918 CACTTG - deletion Rnor_6.0

Additional Information

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-03-26 SS-Sh2b3em1Mcwi-/-  SS-Sh2b3em1Mcwi-/Sh2b3em1Mcwi-  SS-Sh2b3em1Mcwi-/-  SS-Sh2b3em1Mcwi-/Sh2b3em1Mcwi-  Symbol and/or name change 68913 APPROVED