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Strain Registration

Strain: SS-Nppbem2Mcwi

Symbol: SS-Nppbem2Mcwi
Strain: SS-Nppbem2
Substrain: Mcwi
RGD ID: 5508370
Citation ID: RRID:RGD_5508370
Ontology ID: RS:0002933
Alleles: Nppbem2Mcwi
Also Known As: SS-Nppbem2Mcwi; SS-Nppb^[em2Mcwi]
Type: mutant
Available Source: Not Available
Origination: PhysGen Knockouts
Description: This strain was produced by injecting ZFNs targeting the sequence TTCCCAATTCGTCACAgaagctGCTGGAGCTGATAAG into SS/JrHsdMcwi rat embryos. The resulting mutation is a 100-bp deletion of part of intron 1 and exon 2.
Last Known Status: Cryopreserved Sperm (as of 2017-01-26)
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr85163,699,955 - 163,701,314RGD_MAPPER_PIPELINE
mRatBN7.25158,416,813 - 158,418,175RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.05164,796,229 - 164,797,531RGD_MAPPER_PIPELINERnor6.0
Rnor_5.05168,454,278 - 168,455,640RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.45165,062,348 - 165,063,650RGD_MAPPER_PIPELINERGSC3.4






References

References - curated
# Reference Title Reference Citation
1. Knockout rats via embryo microinjection of zinc-finger nucleases. Geurts AM, etal., Science. 2009 Jul 24;325(5939):433.
2. B-Type Natriuretic Peptide Deletion Leads to Progressive Hypertension, Associated Organ Damage, and Reduced Survival: Novel Model for Human Hypertension. Holditch SJ, etal., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11.
3. Arterial Remodeling in B-Type Natriuretic Peptide Knock-Out Females. Holditch SJ, etal., Sci Rep. 2016 May 10;6:25623. doi: 10.1038/srep25623.
4. PhysGen Knockouts PhysGen Knockout strains
5. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Nppbem2Mcwi-var1 chr5 164796229 164797531 GCGAGACAAGAGAGAGCAGGACACCATCGCAGCTGCCTGGCCCATCACTTCTGCAGCATGGATCTCCAGAAGGTGCTGCCCCAGATGATTCTGCTCCTGCTTTTCCTTAATCTGTCGCCGCTGGGAGGTCACTCCCATCCCCTGGGAAGTCCTAGCCAGTCTCCAGAACAATCCACGATGCAGGTGAGCACCGAGGGTCTGCATAGGGAGATGGAGCCTGCCTGAAGGGTTTTGGGCAGCAGCAATGAAAAGACCTCATGTCCTTTGGGAATTAACCACGCGAGAGTCAGGAAACGGAAAGATTGGGCAGCAGATCCCTTAACCGACAGGCACTGTGGAAGGGTGGGGGAGCCAGGTGTGTATGTGTGTGTGTGTCTGAGGTCTGGGCTTCCCAATTCGTCACAGAAGCTGCTGGAGCTGATAAGAGAAAAGTCAGAGGAAATGGCTCAGAGACAGCTCTCAAAGGACCAAGGCCCTACAAAAGAACTTCTAAAAAGAGTCCTTAGGTCTCAAGACAGCGCCTTCCGGATCCAGGAGAGACTTCGAAATTCCAAGATGGCACATAGTTCAAGCTGCTTTGGGCAGAAGATAGACCGGATTGGCGCAGTCAGTCGTTTGGGCTGTGACGGTGAGCACCTACCTTGCCGCTTCCCTGCAAAGCTGCACGCATCCCGTTCCCCTGCATGCCGCCCTCAGAGGCCCCTTGGTTTGCTCTCAGACATACTTGCACAGCCTGCCTCTACCTTACCGACAGTCTTCAAGACCAAGGCAGTCTGTCAGGAAGTCTCACATGGGTACTTCATTACACCGTCCCAGGTGAGCACCTACCTCCTTCAGAGGTGTCACAGGCTTCCCAGGGAACAGACTGCCTGATGTCTGATCACTCTGAGCATCTCCCCTCCGTCTTCACCAAACTGAATTATCCGAGGCAAAGGGCAGGCCCAGTGAGATAGCTTTTCCCAGAGCCGTTAAACTTCGACATCATCTGGGAACCAAAGATGGGGGTGCGGTGTGGCAGGGGAAGCTCAGCTCCTGCCTCAGTTTCACTCCCCAGTCTGACACTGGTTTCTCCTCCCCACAGGGCTGAGGTTGTTTTAGGAAGACCTCCTGGCTGCAGACTCTGGCTTCTGACTCTGCCTGCGGCTCTTCTTTCCCCAGCTCTGGGACCACCTCTCAAGTGATCCTGTTTATTTATTTGTTTATTTATTTATTTTTATGTTGCTGATTTTCTACAAGACTGTTTCTTATCTTCCAGCACAAACTTGCCACAGTGTAATAAACATAGCCTATTTCTTGCTTTTGG - deletion Rnor_6.0

Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-03-26 SS-Nppbem2Mcwi    SS-Nppbem2Mcwi    Symbol updated 68687 APPROVED
2014-03-26 SS-Nppbem2Mcwi    SS-Nppbem2Mcwi    Symbol updated 68687 APPROVED
2014-03-26 SS-Nppbem2Mcwi    SS-Nppbem2Mcwi    Name updated 68913 APPROVED
2014-03-26 SS-Nppbem2Mcwi    SS-Nppbem2Mcwi    Name updated 68913 APPROVED
2013-08-15 SS-Nppbem2Mcwi    SS-Nppbem2Mcwi    Name updated 68913 APPROVED
2013-08-15 SS-Nppbem2Mcwi    SS-Nppbem2Mcwi    Name updated 68913 APPROVED