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Strain Registration

Strain: WUN-Abcc2TR-/HsdRrrc

Symbol: WUN-Abcc2TR-/HsdRrrc
Strain: WUN-Abcc2TR-
Substrain: HsdRrrc
RGD ID: 5508304
Citation ID: RRID:RRRC_00442
Ontology ID: RS:0002917
Alleles: Abcc2TR-;   Abcc2
Previously known as: WUN-Abcc2TR-/HsdRrrc;TR- rat;HsdAmc:TR-Abcc2;Mrp2 mutation; WUN-Abcc2TR-/HsdRrrc
Type: mutant
Source: Rat Resource and Research Center
Origin: Spontaneous 1-bp deletion mutation occurred on a Wistar Unilever maintained at the Amsterdam Academic Medical Center (AMC). This mutation at amino acid 393 resulting a frameshift and premature stop at position 401.
Coat Color: Albino
Last Known Status: Cryopreserved Embryo; Cryopreserved Sperm (as of 2019-08-02)
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21242,664,657 - 242,723,239RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01263,554,426 - 263,612,556RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01270,999,832 - 271,057,750RGD_MAPPER_PIPELINERnor5.0





Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. Adenosine triphosphate-binding cassette subfamily C member 2 is the major transporter of the hepatobiliary imaging agent (99m)Tc-mebrofenin. Bhargava KK, etal., J Nucl Med. 2009 Jul;50(7):1140-6. doi: 10.2967/jnumed.109.062448. Epub 2009 Jun 12.
2. Expression of rat hepatic multidrug resistance-associated proteins and organic anion transporters in pregnancy. Cao J, etal., Am J Physiol Gastrointest Liver Physiol 2002 Sep;283(3):G757-66.
3. Upregulation of brain expression of P-glycoprotein in MRP2-deficient TR(-) rats resembles seizure-induced up-regulation of this drug efflux transporter in normal rats. Hoffmann K and Löscher W, Epilepsia. 2007 Apr;48(4):631-45. doi: 10.1111/j.1528-1167.2006.00939.x.
4. Hereditary chronic conjugated hyperbilirubinemia in mutant rats caused by defective hepatic anion transport. Jansen PL, etal., Hepatology. 1985 Jul-Aug;5(4):573-9.
5. Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene. Paulusma CC, etal., Science 1996 Feb 23;271(5252):1126-8.
6. Strains registered by Harlan Laboratories, Inc. Personal communication with Harlan Laboratories
7. Data registered by the Rat Resource & Research Center Personal Communication with Rat Resource & Research Center
8. RGD Strain RSO annotation pipeline RGD Automated Pipelines
9. Characterization of SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats using loperamide, paclitaxel, sulfasalazine, and carboxydichlorofluorescein pharmacokinetics. Zamek-Gliszczynski MJ, etal., Drug Metab Dispos. 2012 Sep;40(9):1825-33. doi: 10.1124/dmd.112.046508. Epub 2012 Jun 18.

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics Autosomal recessive mutation on Abcc2 (previous gene name Mrp2). Defective canalicular multispecific organic anion transporter (cMOAT), which mediates hepatobiliary excretion of nonbile salt organic anions. TR (-) rats have reduced mesenger RNA level for the Abcc2 gene. 2292495
strain_characteristics Spontaneous mutation that arose in a colony of Wistar Unilever inbred rats. 2292495
strain_life_disease Animals have mild chronic hyperbilirubinemia. 2292495
strain_reproduction Poor producers; random intra-strain mating; reproductive decline age: 6-8 months 2292495

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-03-26 WUN-Abcc2TR-/HsdRrrc    WUN-Abcc2TR-/HsdRrrc    Symbol updated 68687 APPROVED
2014-03-26 WUN-Abcc2TR-/HsdRrrc    WUN-Abcc2TR-/HsdRrrc    Symbol updated 68687 APPROVED
2014-03-26 WUN-Abcc2TR-/HsdRrrc    WUN-Abcc2TR-/HsdRrrc    Name updated 68913 APPROVED
2014-03-26 WUN-Abcc2TR-/HsdRrrc    WUN-Abcc2TR-/HsdRrrc    Name updated 68913 APPROVED
2012-04-19 WUN-Abcc2TR-/HsdRrrc    WUN-Abcc2TR-/HsdRrrc    Name updated 68913 APPROVED
2012-04-19 WUN-Abcc2TR-/HsdRrrc    WUN-Abcc2TR-/HsdRrrc    Name updated 68913 APPROVED

Database Acc Id Source(s)
RRRC RRRC:00442 RGD