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Strain Registration

Strain: FHH.PCK-(D9Rat35-D9Rat70)/Mcwi

Symbol: FHH.PCK-(D9Rat35-D9Rat70)/Mcwi
Strain: FHH.PCK-(D9Rat35-D9Rat70)
Substrain: Mcwi
RGD ID: 5147594
Citation ID: RRID:RGD_5147594
Ontology ID: RS:0002296
Alleles: Pkhd1pck
Previously known as: FHH.PCK-(D9Rat35-D9Rat70)/Mcwi; FHH.Pkhd1; FHH.Pkhd1
Type: congenic
Source: Medical College of Wisconsin, Milwaukee, Wisconsin
Origin: A FHH/EurMcwi male was crossed with a PCK/CrljCrl-Pkhd1pck/Crl female, and the male progeny were backcrossed to FHH/EurMcwi females for five generations by marker assisted breeding. In each generation, males were genotyped by fluorescent genotyping for three markers within the Pkhd1 gene, and 98 markers evenly spaced throughout the genome.
Last Known Status: Unknown
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2917,220,476 - 25,268,236RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0919,794,101 - 29,075,268RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0918,672,124 - 27,914,444RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.4912,916,127 - 21,667,256RGD_MAPPER_PIPELINERGSC3.4





References

References - curated
# Reference Title Reference Citation
1. Role of genetic modifiers in an orthologous rat model of ARPKD. O'Meara CC, etal., Physiol Genomics. 2012 Aug 1;44(15):741-53. doi: 10.1152/physiolgenomics.00187.2011. Epub 2012 Jun 5.
2. Data registered by Dr. Moreno Personal communication between Dr. Carol Moreno and the RGD curators.
3. RGD Strain RSO annotation pipeline RGD Automated Pipelines
4. Genetic susceptibility and loss of Nr4a1 enhances macrophage-mediated renal injury in CKD. Westbrook L, etal., J Am Soc Nephrol. 2014 Nov;25(11):2499-510. doi: 10.1681/ASN.2013070786. Epub 2014 Apr 10.

Region

Position Markers

Flank 1 / 1 (D9Rat35)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2917,220,476 - 17,220,609 (+)MAPPER
Rnor_6.0919,794,101 - 19,794,233NCBI
Rnor_5.0918,672,124 - 18,672,256UniSTS
RGSC_v3.4912,916,128 - 12,916,260UniSTS
RGSC_v3.4912,916,127 - 12,916,260RGD
RGSC_v3.1912,913,450 - 12,913,582RGD
Celera914,944,299 - 14,944,431UniSTS
RH 3.4 Map9107.0RGD
RH 3.4 Map9107.0UniSTS
RH 2.0 Map9110.1RGD
SHRSP x BN Map915.0998RGD

Flank 2 / 1 (D9Rat70)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2925,268,044 - 25,268,236 (+)MAPPER
Rnor_6.0929,075,079 - 29,075,268NCBI
Rnor_5.0927,914,255 - 27,914,444UniSTS
RGSC_v3.4921,667,066 - 21,667,255RGD
RGSC_v3.4921,667,067 - 21,667,256UniSTS
RGSC_v3.1921,668,480 - 21,668,669RGD
Celera922,834,240 - 22,834,435UniSTS
RH 3.4 Map9233.3UniSTS
RH 3.4 Map9233.3RGD
RH 2.0 Map9199.9RGD
SHRSP x BN Map923.2398RGD
Cytogenetic Map9 RGD

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics many genes were identified that were misexpressed in this strain and also in PCK/CrljCrl-Pkhd1pck/Crl 9685714
strain_characteristics Pcdh9 is down regulated in this strain and also in PCK/CrljCrl-Pkhd1pck/Crl 9685714
strain_life_disease At 6 months of age, these develop a resistance to ARPKD with normal kidney weight and reduced renal cysts and improved renal function 9685714