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Strain Registration

Strain: GK/Ox

Symbol: GK/Ox
Strain: GK
Substrain: Ox
RGD ID: 4889464
Citation ID: RRID:RGD_4889464
Ontology ID: RS:0002495
Previously known as: GK/Ox
Type: inbred
Source: The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
Origin: Original breeders are from a colony in Paris (CNRS URA 307, Paris, France) which were obtained in 1995 and since then bred locally in Oxford, UK
Last Known Status: Unknown





Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Mapping diabetes QTL in an intercross derived from a congenic strain of the Brown Norway and Goto-Kakizaki rats. Collins SC, etal., Mamm Genome. 2006 Jun;17(6):538-47. Epub 2006 Jun 12.
2. Direct quantitative trait locus mapping of mammalian metabolic phenotypes in diabetic and normoglycemic rat models. Dumas ME, etal., Nat Genet. 2007 Apr 15;.
3. Chromosomal mapping of pancreatic islet morphological features and regulatory hormones in the spontaneously diabetic (Type 2) Goto-Kakizaki rat. Finlay C, etal., Mamm Genome. 2010 Oct;21(9-10):499-508. Epub 2010 Sep 29.
4. Chromosomal mapping of genetic loci associated with non-insulin dependent diabetes in the GK rat Gauguier D, etal., Nat Genet 1996 Jan;12(1):38-43
5. RGD Strain RSO annotation pipeline RGD Automated Pipelines
6. Pathophysiological, genetic and gene expression features of a novel rodent model of the cardio-metabolic syndrome. Wallis RH, etal., PLoS ONE. 2008 Aug 13;3(8):e2962.

Region

Strain QTL Data
Symbol Name Trait
Niddm67 Non-insulin dependent diabetes mellitus QTL 67 blood glucose amount   (VT:0000188)    
Niddm69 Non-insulin dependent diabetes mellitus QTL 69 blood insulin amount   (VT:0001560)    
Pancm2 Pancreatic morphology QTL 2 pancreatic beta cell morphology trait   (VT:0005217)    
Scort2 Serum corticosterone level QTL 2 blood corticosterone amount   (VT:0005345)    
Damaging Variants
Number of Damaging Variants
SampleRnor_6.0Rnor_5.0RGSC_v3.4
GK/Ox (ICL) 717
GK/Ox (KNAW) 926
GK/Ox (RGD) 1079


Additional Information