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Strain Registration

Strain: SHRSP.WKY-(D1Smu13-D1Wox33)/Izm

Symbol: SHRSP.WKY-(D1Smu13-D1Wox33)/Izm
Strain: SHRSP.WKY-(D1Smu13-D1Wox33)
Substrain: Izm
RGD ID: 4889411
Citation ID: RRID:RGD_4889411
Ontology ID: RS:0002492
Also Known As: NBRP Rat No: 0704; SHRSP.WKY-(D1Smu13-D1Wox33)/Izm; SP.wch1.72; SHRSP.wch1.72
Type: congenic
Available Source: National BioResource Project for the Rat in Japan
Origination: Department of Functional Pathology, Shimane University School of Medicine, Izumo, Japan
Description: About 100 male pups were obtained by breeding SHRSP/Izm and SHRSP.WKY-(D1Smu13-D1Arb21)/Izm; one pup that had the right recombination was found and backcrossed to the parental strain to get the hetrozygotes, which were then mated brother-sister to get the desired congenic strain
Coat Color: Albino
Inbred Generations: F30
Last Known Status: Cryopreserved Sperm
Research Usage Cardio- Hypertension
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21156,170,341 - 156,170,557RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01166,884,926 - 166,885,141RGD_MAPPER_PIPELINERnor6.0
Rnor_5.02224,991,853 - 224,991,955RGD_MAPPER_PIPELINERnor5.0
Rnor_5.01173,074,640 - 174,300,801RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41160,754,901 - 160,755,065RGD_MAPPER_PIPELINERGSC3.4
RGSC_v3.42198,300,754 - 198,300,855RGD_MAPPER_PIPELINERGSC3.4





References

References - curated
# Reference Title Reference Citation
1. A nonsense mutation of Stim1 identified in stroke-prone spontaneously hypertensive rats decreased the store-operated calcium entry in astrocytes. Ohara H and Nabika T, Biochem Biophys Res Commun. 2016 Aug 5;476(4):406-411. doi: 10.1016/j.bbrc.2016.05.134. Epub 2016 May 27.
2. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
3. RGD Strain RSO annotation pipeline RGD Automated Pipelines
4. A 1.8-Mbp fragment on chromosome 1 affects sympathetic response to stress: evaluation in reciprocal congenic strains between stroke-prone spontaneously hypertensive rat and Wistar-Kyoto rat. Xiao B, etal., J Hypertens. 2010 Nov 8.

Region

Position Markers

Flank 1 / 1 (D1Smu13)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21156,170,341 - 156,170,557 (+)MAPPER
Rnor_6.01166,884,926 - 166,885,141NCBI
Rnor_5.01173,074,640 - 173,074,855UniSTS
Celera1154,248,961 - 154,249,176UniSTS
Cytogenetic Map1 RGD

Flank 2 / 1 (D1Wox33)
Rat AssemblyChrPosition (strand)Source
Rnor_5.02224,991,853 - 224,991,955NCBI
Rnor_5.01174,300,636 - 174,300,801NCBI
RGSC_v3.41160,754,901 - 160,755,065RGD
RGSC_v3.42198,300,754 - 198,300,855RGD
RGSC_v3.12198,263,508 - 198,263,609RGD
RH 3.4 Map11289.0UniSTS
RH 3.4 Map11289.0RGD
Cytogenetic Map1q32UniSTS
Strain QTL Data
Symbol Name Trait
Cstrr2 Cold stress response QTL 2 urine catecholamine amount   (VT:0010502)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_life_disease This strain shows hypertension and lower sympathetic stress response than SHRSP/Izm. 1302502

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-05-27 SHRSP.WKY-(D1Smu13-D1Wox33)/Izm    SHRSP.WKY-(D1Smu13-D1Wox33)/Izm    Name updated 68913 APPROVED
2015-05-27 SHRSP.WKY-(D1Smu13-D1Wox33)/Izm    SHRSP.WKY-(D1Smu13-D1Wox33)/Izm    Name updated 68913 APPROVED