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Strain: WI-Grm2em1

Symbol: WI-Grm2em1
Strain: WI-Grm2em1
RGD ID: 41410881
Citation ID: RRID:RGD_41410881
Ontology ID: RS:0004857
Alleles: Grm2em1
Also Known As: WI-Grm2em1; WI-Grm2^[em1]
Type: mutant
Available Source: Not Available
Origination: Transposagen Biopharmaceutical
Description: This mutant rat strain was produced by Transposagen Biopharmaceutical and available in mGluR2+/- breeding pairs. The genome modification created a premature stop codon insertion that causes a nonsense mutation at amino acid C407, deleting the transmembrane and intracellular domains of the receptor and rendering the gene nonfunctional.
Last Known Status: Unknown
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28107,280,099 - 107,293,159RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.08115,344,999 - 115,358,628RGD_MAPPER_PIPELINERnor6.0
Rnor_5.08114,705,123 - 114,718,193RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.48111,837,086 - 111,850,133RGD_MAPPER_PIPELINERGSC3.4


References - curated
# Reference Title Reference Citation
1. Deletion of the type 2 metabotropic glutamate receptor increases heroin abuse vulnerability in transgenic rats. Gao JT, etal., Neuropsychopharmacology. 2018 Dec;43(13):2615-2626. doi: 10.1038/s41386-018-0231-5. Epub 2018 Oct 3.
2. Deletion of Type 2 Metabotropic Glutamate Receptor Decreases Sensitivity to Cocaine Reward in Rats. Yang HJ, etal., Cell Rep. 2017 Jul 11;20(2):319-332. doi: 10.1016/j.celrep.2017.06.046.


Additional Information

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-02-17 WI-Grm2em1    WI-Grm2em1    Symbol and/or name change 68913 APPROVED