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Strain Registration

Strain: SD-Ctnsem1Odev

Symbol: SD-Ctnsem1Odev
Strain: SD-Ctnsem1
Substrain: Odev
RGD ID: 401938653
Citation ID: RRID:RGD_401938653
Ontology ID: RS:0005325
Alleles: Ctnsem1Odev
Also Known As: SD-Ctns^[em1Odev]
Type: mutant
Available Source: Contact Olivier Devuyst at Email: olivier.devuyst@uzh.ch or URL: https://www.physiol.uzh.ch/en/research/institutegroups/grdevuyst/membersdevuyst/OlivierDevuyst.html
Origination: University of Zurich - Institute of Physiology, Mechanisms of Inherited Kidney Disorders Group Winterthurerstrasse 190 CH-8057 Zürich
Description: The Ctns gen was deleted by oocyte injection of the CRISPER/Cas9 system (PolyGene AG, Zurich,Switzer-land). Two single guideRNAs(sgRNAs) targeting exon3 of Ctns were selected :CRISPR1a: ACCAACGTCAGCATTAC-CCT(TGG), CRISPR1b: CCATTTACCAGCTTCACAGT(GGG). This Ctns rat line harboring a deletion of 12bp and insertion of 8bp resultingin a premature stop codon in the exon3 of Ctns.
Genetic Status: Homozygous
Last Known Status: Live Animals (as of 2024-03-18)
Research Usage Cystinosis
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21057,810,970 - 57,810,981RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01059,749,250 - 59,772,475RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01059,488,895 - 59,503,993RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41060,060,254 - 60,075,352RGD_MAPPER_PIPELINERGSC3.4






References

References - curated
# Reference Title Reference Citation
1. Multisystem involvement, defective lysosomes and impaired autophagy in a novel rat model of nephropathic cystinosis. Krohn P, etal., Hum Mol Genet. 2022 Jul 7;31(13):2262-2278. doi: 10.1093/hmg/ddac033.

Region


Additional Information