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Strain Registration

Strain: SD-Slc9a6 em1Moro/Rrrc

Symbol: SD-Slc9a6 em1Moro/Rrrc
Strain: SD-Slc9a6 em1
Substrain: MoroRrrc
RGD ID: 401938647
Citation ID: RRID:RGD_401938647
Ontology ID: RS:0005308
Alleles: Slc9a6 em1Moro
Also Known As: NHE6-null rat; SD-Slc9a6 ^[em1Moro]/Rrrc
Type: mutant
Available Source: deposited at RRRC
Origination: Dr. Eric Morrow at Brown University 70 Ship Street, Box G-E4 Providence RI 02912 USA
Description: Crispr-Cas was used to introduce a 2bp insertion of TT to create a stop codon in exon 7 of SLC9a6 gene, causing termination of translation. The strain was rederived at RRRC.
Genetic Status: Homozygous
Last Known Status: Live Animals (as of 2023-12-18)
Research Usage neurodevelopment/neurodegeneration
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X134,443,830 - 134,443,831RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0X158,979,081 - 159,045,019RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0X153,620,082 - 153,675,717RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.4X141,146,237 - 141,201,234RGD_MAPPER_PIPELINERGSC3.4






References

References - curated
# Reference Title Reference Citation
1. Early lysosome defects precede neurodegeneration with amyloid-β and tau aggregation in NHE6-null rat brain. Lee Y, etal., Brain. 2021 Dec 20. pii: 6470622. doi: 10.1093/brain/awab467.

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