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Strain Registration

Strain: F344-Ppargm1Kyo

Symbol: F344-Ppargm1Kyo
Strain: F344-Ppargm1
Substrain: Kyo
RGD ID: 38676254
Citation ID: RRID:RGD_38676254
Ontology ID: RS:0004902
Alleles: Ppargm1Kyo
Previously known as: NBRP Rat No: 0764
Type: mutant
Source: National BioResource Project for the Rat in Japan
Origin: By using ENU mutagenesis followed by MuT-POWER screening of the KURMA (Kyoto University Rat Mutant Archive) samples, the depositors generated a heterozygous PPARg mutant (Ppargmkyo/+) rat with a missense mutation (G488T p.C163F in Pparg1 or G578T p.C193F for Pparg2) in Pparg. The PpargG488T homozygous rats are embryonic lethal. Heterozygous Ppargmkyo/+ rats showed reduced fat mass with adipocyte hypertrophy and insulin resistance, which were highly predictable from known actions of Pparg agonists and phenotypes of patients with the PPARG mutation.
Genetic Status: Heterozygous
Coat Color: white
Last Known Status: Cryopreserved Sperm (as of 2020-09-16)
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24148,423,102 - 148,548,471RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.04147,274,055 - 147,399,383RGD_MAPPER_PIPELINERnor6.0
Rnor_5.04210,562,928 - 210,688,585RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.44151,492,220 - 151,617,331RGD_MAPPER_PIPELINERGSC3.4





References

References - curated
# Reference Title Reference Citation
1. Fat Mass Reduction With Adipocyte Hypertrophy and Insulin Resistance in Heterozygous PPARĪ³ Mutant Rats. Gumbilai V, etal., Diabetes. 2016 Oct;65(10):2954-65. doi: 10.2337/db15-1422. Epub 2016 Jul 5.
2. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP

Region


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-09-16 F344-Ppargm1Kyo    F344-Hcn1em4Kyo (COPY)    Symbol and/or name change 68913 APPROVED