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Strain: F344-Depdc5em1Kyo+/-

Symbol: F344-Depdc5em1Kyo+/-
Strain: F344-Depdc5em1+/-
Substrain: Kyo
RGD ID: 38599157
Citation ID: RRID:RGD_38599157
Ontology ID: RS:0004820
Alleles: Depdc5em1Kyo
Type: mutant
Source: National Bio Resource Project Rat in Japan
Origin: TALEN mRNAs targeting exon 2 of rat Depdc5 were microinjected into fertilized eggs of Fisher 344 (F344) rats to yield two founder mutant rats named Depdc5em1kyo (c.40_44delins17/p.Gly15*) and Depdc5em2kyo (c.39_55delinsT/p.Lys13fs*8). The genome edited fragment was identified by PCR. A 267 bp band was detected for wildtype, a 279 bp band for Depdc5em1kyo mutant and a 251 bp band for Depdc5em2kyo mutant. Depdc5 mutant homozygous pups were never observed at birth. Deletion of both alleles resulted in in utero lethality started around E14.5.
Last Known Status: Unknown
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21477,732,297 - 77,862,924RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01483,089,000 - 83,219,576RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01483,775,510 - 83,906,381RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41483,484,354 - 83,614,818RGD_MAPPER_PIPELINERGSC3.4

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Mammalian Phenotype


References - curated
# Reference Title Reference Citation
1. Depdc5 knockout rat: A novel model of mTORopathy. Marsan E, etal., Neurobiol Dis. 2016 May;89:180-9. doi: 10.1016/j.nbd.2016.02.010. Epub 2016 Feb 9.


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