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Strain Registration

Strain: BN-Themism1Adej

Symbol: BN-Themism1Adej
Strain: BN-Themism1Adej
Substrain: Adej
RGD ID: 38599155
Citation ID: RRID:RGD_38599155
Ontology ID: RS:0004819
Alleles: Themism1Adej
Type: mutant
Source: UMR Inserm, U1043, Toulouse, France, UMR CNRS, U5282, Toulouse, France, Universit de Toulouse, UPS, Centre de Physiopathologie de Toulouse Purpan (CPTP), Toulouse, France
Origin: This autosomal recessive mutation occurred spontaneously in a Brown-Norway rat colony and was identified as causing marked T cell lymphopenia. The mutation was identified as a frameshift mutation caused by a four-nucleotide insertion in the Themis gene, leading to its disruption.
Genetic Status: Homozygous
Last Known Status: Unknown
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2116,433,906 - 16,623,889RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0117,152,973 - 17,378,225RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0118,308,043 - 18,532,366RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.4117,032,677 - 17,226,924RGD_MAPPER_PIPELINERGSC3.4





References

References - curated
# Reference Title Reference Citation
1. A spontaneous mutation of the rat Themis gene leads to impaired function of regulatory T cells linked to inflammatory bowel disease. Chabod M, etal., PLoS Genet. 2012 Jan;8(1):e1002461. doi: 10.1371/journal.pgen.1002461. Epub 2012 Jan 19.

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