Strain Report - Rat Genome Database

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Strain: SD-Cpem1Ang-/-

Symbol: SD-Cpem1Ang-/-
Strain: SD-Cpem1-/-
Substrain: Ang
RGD ID: 38501061
Citation ID: RRID:RGD_38501061
Ontology ID: RS:0004803
Alleles: Cpem1Ang
Also Known As: SD-Cp^[em1Ang-/-]
Type: mutant
Available Source: Not Available
Description: The homozygous Cp mutant rats are littermates of cross of heterozygotes Cp mutant rats . The mutations created by CRISPR/Cas9 contained a 54- bp deletion and a 2-bp insertion in exon1 of Cp, resulted a premature stop codon in exon 2. The sgRNAcr377 (TacGene, Paris, France) used targeted the exon 1 of Cp and had the following sequence: 59-GGAAT-TACTGAAGCAGTTT-39.
Genetic Status: Homozygous
Last Known Status: Unknown
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22102,439,433 - 102,498,075RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.02104,744,249 - 104,803,034RGD_MAPPER_PIPELINERnor6.0
Rnor_5.02124,467,383 - 124,524,140RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.42105,086,278 - 105,135,367RGD_MAPPER_PIPELINERGSC3.4


References - curated
# Reference Title Reference Citation
1. Ceruloplasmin deficiency does not induce macrophagic iron overload: lessons from a new rat model of hereditary aceruloplasminemia. Kenawi M, etal., FASEB J. 2019 Dec;33(12):13492-13502. doi: 10.1096/fj.201901106R. Epub 2019 Sep 27.


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