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Strain: SD-Cpem1Ang+/+

Symbol: SD-Cpem1Ang+/+
Strain: SD-Cpem1+/+
Substrain: Ang
RGD ID: 38501059
Citation ID: RRID:RGD_38501059
Ontology ID: RS:0004801
Type: mutant
Source: Not Available
Origin: The wild type rats were littermates of cross of heterozygotes Cp mutant rats. The mutations created by CRISPR/Cas9 contained a 54- bp deletion and a 2-bp insertion in exon1 of Cp, resulted a premature stop coden in exon 2. The sgRNAcr377 (TacGene, Paris, France) used targeted the exon 1 of Cp and had the following sequence: 59-GGAAT-TACTGAAGCAGTTT-39.
Genetic Status: Wild Type
Last Known Status: Unknown


References - curated
# Reference Title Reference Citation
1. Ceruloplasmin deficiency does not induce macrophagic iron overload: lessons from a new rat model of hereditary aceruloplasminemia. Kenawi M, etal., FASEB J. 2019 Dec;33(12):13492-13502. doi: 10.1096/fj.201901106R. Epub 2019 Sep 27.


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