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Strain Registration

Strain: SD-Fosem1Yossi

Symbol: SD-Fosem1Yossi
Strain: SD-Fosem1
Substrain: Yossi
RGD ID: 329849011
Citation ID: RRID:RGD_329849011
Ontology ID: RS:0005281
Also Known As: NBRP Rat No: 0968; SD-Fos^[em1Yossi]
Type: mutant
Available Source: National BioResource Project for the Rat in Japan
Origination: National BioResource Project for the Rat in Japan
Description: SD rats (Slc:SD) in which the c-Fos gene (ENSRNOG00000008015) was disrupted by the CRISPR/Cas9 system. Two guide RNAs and Cas9 protein were injected into the pronucleus of fertilized eggs of SD rats. After injection, they were transferred into the oviducts of the recipient rats and born. The founder rat (line 12) showed abnormal teeth, and PCR and sequencing analysis revealed that 1,067 bases including Exon 1 were deleted. The founder rat were mated with SD rats and bred.
Genetic Status: Heterozygous
Last Known Status: Cryopreserved Sperm (as of 2023-06-09)






References

References - curated
# Reference Title Reference Citation
1. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP

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