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Strain Registration

Strain: LE-Pvalbem2(cre)Koba

Symbol: LE-Pvalbem2(cre)Koba
Strain: LE-Pvalbem2(cre)
Substrain: Koba
RGD ID: 329849003
Citation ID: RRID:RGD_329849003
Ontology ID: RS:0005276
Also Known As: NBRP Rat No: 0931; LE-Pvalb^[em2(cre)Koba]
Type: mutant
Available Source: National BioResource Project for the Rat in Japan
Origination: National BioResource Project for the Rat in Japan
Description: A complex of Cas9 protein and gRNA was introduced into Iar:LE fertilized rat eggs by electroporation. Combi-CRISPR (Yoshimi K. et al.) was used to induce knock-in. Knock-in rats were selected and crossed with wild-type rats to establish this strain. Sequence features: the intron just before the fourth exon of the Pvalb gene (intron 3) is deleted by NHEJ after double-strand break by one base compared to the wild-type. ---ttggcgggccagaacctcagggg---(wild-type) ---ttggcgggccagaacc-cagggg---(knock-in)
Genetic Status: Heterozygous
Coat Color: black and white
Last Known Status: Unknown






References

References - curated
# Reference Title Reference Citation
1. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP

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