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Strain Registration

Strain: SHR-Chr 6MWF/Rkb

Symbol: SHR-Chr 6MWF/Rkb
Strain: SHR-Chr 6MWF
Substrain: Rkb
RGD ID: 2317891
Citation ID: RRID:RGD_2317891
Ontology ID: RS:0002404
Also Known As: SHR-Chr 6MWF/Rkb; SHR-Chr 6^[MWF]/Rkb
Type: consomic
Available Source: Not Available
Origination: Department of Clinical Pharmacology and Toxicology, Charite-Universitatsmedizin Berlin, Berlin, Germany
Description: SHR/FubRkb male was crossed with female MWF/FubRkb to get F1 animals which in turn were backcrossed with female SHR/FubRkb, this was repeated for 7 generations, tested by sequential marker-assisted backcrossing
Last Known Status: Unknown





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Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. RGD Strain RSO annotation pipeline RGD Automated Pipelines
2. A genetic locus on MWF rat chromosome 6 affects kidney damage in response to L-NAME treatment in spontaneously hypertensive rats. Schulz A, etal., Physiol Genomics. 2010 Apr 13.

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_drgs_chems exhibited premature death (60% died between week 12-13 and rest 14-15) when treated with 20 mg/l L-NAME 2317887
strain_life_disease Urinary albumin excretion levels were smaller as compared to MWF 2317887
strain_life_disease Nephrectomy increased the urinary albumin excretion levels 2317887