Strain Report - Rat Genome Database

Name: Taiep/Dun
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Strain Registration

General

Strain: Taiep/Dun
Symbol:	Taiep/Dun
Strain:	Taiep
Substrain:	Dun
RGD ID:	2317278
Citation ID:	RRID:RGD_2317278
Ontology ID:	RS:0002383
Previously known as:	taiep;taiep
Type:	mutant
Source:	Dept of Medical Sciences, University of Wisconsin-Madison, Madison, Wisconsin
Origin:	These mutants were found in Sprague-Dawley rats at University of Puebla in 1989
Last Known Status:	Unknown

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

demyelinating disease (IAGP)

multiple sclerosis (IAGP)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal axon morphology (IAGP)

abnormal chemokine level (IAGP)

demyelination (IAGP)

optic nerve degeneration (IAGP)

tremors (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	A mutation in the Tubb4a gene leads to microtubule accumulation with hypomyelination and demyelination.	Duncan ID, etal., Ann Neurol. 2017 May;81(5):690-702. doi: 10.1002/ana.24930. Epub 2017 May 9.
2.	Mapping of taiep rat phenotype to rat Chromosome 9.	Li FY, etal., Mamm Genome. 2003 Oct;14(10):703-5.
3.	The temporal progression of the myelination defect in the taiep rat.	Lunn KF, etal., J Neurocytol. 1997 May;26(5):267-81.
4.	RGD Strain RSO annotation pipeline	RGD Automated Pipelines
5.	Analysis of chemokines and receptors expression profile in the myelin mutant taiep rat.	Soto-Rodriguez G, etal., Oxid Med Cell Longev. 2015;2015:397310. doi: 10.1155/2015/397310. Epub 2015 Mar 25.
6.	Slowly progressive axonal degeneration in a rat model of chronic, nonimmune-mediated demyelination.	Wilkins A, etal., J Neuropathol Exp Neurol. 2010 Dec;69(12):1256-69. doi: 10.1097/NEN.0b013e3181ffc317.

Region

Additional Information

RGD Curation Notes

Note Type	Note	Reference
strain_characteristics	Myelin sheaths were detected in the ventral column at day 1, intracranial optic nerves at 10 days, and corticospinal tracts at 20 days of age.	2317275
strain_life_disease	taiep is an acronym for trembling (3-4 wks), ataxia (4 months), immobility (5-6 months), epilepsy (5-6 months) and paresis (7 months onwards)	2317274
strain_other	Genes responsible for these phenotypes are localized to a 5.9 cM region around D9Rat44 between the telomere and D9Rat88	2317274
strain_phys_biochem	Less than normal amount of myelin is formed and loss of myelin from each region of CNS examined was seen after 1 month of age.	2317275
strain_phys_biochem	These phenotypes are caused by progressive accumulation of microtubules in oligodendrocytes that disturb the traffic of microtubule-dependent mRNA	2317274
strain_reproduction	These can reproduce and live up to 18 months	2317275

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2010-03-26	Taiep/Dun		Taiep/Dun		Name updated	68913	APPROVED
2010-03-26	Taiep/Dun		Taiep/Dun		Name updated	68913	APPROVED

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Strain: Taiep/Dun

Mammalian Phenotype