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Strain: Taiep/Dun

Symbol: Taiep/Dun
Strain: Taiep
Substrain: Dun
RGD ID: 2317278
Citation ID: RRID:RGD_2317278
Ontology ID: RS:0002383
Previously known as: taiep;taiep
Type: mutant
Source: Dept of Medical Sciences, University of Wisconsin-Madison, Madison, Wisconsin
Origin: These mutants were found in Sprague-Dawley rats at University of Puebla in 1989
Last Known Status: Unknown

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Mammalian Phenotype


References - curated
# Reference Title Reference Citation
1. A mutation in the Tubb4a gene leads to microtubule accumulation with hypomyelination and demyelination. Duncan ID, etal., Ann Neurol. 2017 May;81(5):690-702. doi: 10.1002/ana.24930. Epub 2017 May 9.
2. Mapping of taiep rat phenotype to rat Chromosome 9. Li FY, etal., Mamm Genome. 2003 Oct;14(10):703-5.
3. The temporal progression of the myelination defect in the taiep rat. Lunn KF, etal., J Neurocytol. 1997 May;26(5):267-81.
4. RGD Strain RSO annotation pipeline RGD Automated Pipelines
5. Analysis of chemokines and receptors expression profile in the myelin mutant taiep rat. Soto-Rodriguez G, etal., Oxid Med Cell Longev. 2015;2015:397310. doi: 10.1155/2015/397310. Epub 2015 Mar 25.
6. Slowly progressive axonal degeneration in a rat model of chronic, nonimmune-mediated demyelination. Wilkins A, etal., J Neuropathol Exp Neurol. 2010 Dec;69(12):1256-69. doi: 10.1097/NEN.0b013e3181ffc317.


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics Myelin sheaths were detected in the ventral column at day 1, intracranial optic nerves at 10 days, and corticospinal tracts at 20 days of age. 2317275
strain_life_disease taiep is an acronym for trembling (3-4 wks), ataxia (4 months), immobility (5-6 months), epilepsy (5-6 months) and paresis (7 months onwards) 2317274
strain_other Genes responsible for these phenotypes are localized to a 5.9 cM region around D9Rat44 between the telomere and D9Rat88 2317274
strain_phys_biochem Less than normal amount of myelin is formed and loss of myelin from each region of CNS examined was seen after 1 month of age. 2317275
strain_phys_biochem These phenotypes are caused by progressive accumulation of microtubules in oligodendrocytes that disturb the traffic of microtubule-dependent mRNA 2317274
strain_reproduction These can reproduce and live up to 18 months 2317275

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-03-26 Taiep/Dun    Taiep/Dun    Name updated 68913 APPROVED
2010-03-26 Taiep/Dun    Taiep/Dun    Name updated 68913 APPROVED