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Strain Registration

Strain: WAG-F8m1Ycb

Symbol: WAG-F8m1Ycb
Strain: WAG-F8m1
Substrain: Ycb
RGD ID: 2314904
Citation ID: RRID:RGD_2314904
Ontology ID: RS:0003433
Alleles: F8m1Ycb
Also Known As: WAG-F8m1Ycb; WAG-F8m1Ycb; WAG-F8^[m1Ycb]
Type: mutant
Available Source: Comparative Medicine, Yale University, Connecticut
Origination: Comparative Medicine, Yale University, Connecticut
Description: This mutant strain carrying a naturally occurring missense mutation displays inherited coagulopathy was arising in an inbred colony of WAG/RijYcb (RGD:2314861). Mutation in the nucleotide 578 of the rat F8 gene changes amino acid 193 in the rat protein(amino acid 176 in human)from Leucine to Proline.
Last Known Status: Unknown
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.218145,719 - 145,719RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.018394,478 - 394,478RGD_MAPPER_PIPELINERnor6.0
Rnor_5.018413,447 - 444,491RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.418121,134 - 162,008RGD_MAPPER_PIPELINERGSC3.4





Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. WAG-F8(m1Ycb) rats harboring a factor VIII gene mutation provide a new animal model for hemophilia A. Booth CJ, etal., J Thromb Haemost. 2010 Nov;8(11):2472-7. doi: 10.1111/j.1538-7836.2010.03978.x.
2. Strains registered by Dr. Carmen J Booth Personal communication between Dr. Carmen J Booth and the RGD curators.
3. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
F8m1Ycb-var1 chr18 145719 145719 T C point_mutation mRatBN7.2
F8m1Ycb-var1 chr18 394478 394478 T C point_mutation Rnor_6.0

Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-05-29 WAG-F8m1Ycb    WAG-F8m1Ycb    Symbol and/or name change 68913 APPROVED
2013-06-17 WAG-F8m1Ycb    WAG-F8m1Ycb    Name updated 68913 APPROVED
2013-06-17 WAG-F8m1Ycb    WAG-F8m1Ycb    Name updated 68913 APPROVED