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Strain Registration

Strain: BRAT-Avpdi/BluHsd

Symbol: BRAT-Avpdi/BluHsd
Strain: BRAT-Avpdi
Substrain: BluHsd
Full Name: Brattleboro
RGD ID: 2314655
Citation ID: RRID:RGD_2314655
Ontology ID: RS:0002019
Alleles: Avpdi
Also Known As: BB; HsdBlu:BRAT-Avpdi; BRAT-Avp^[di]/BluHsd
Type: mutant
Available Source: Harlan
Description: Hereditary hypothalamic diabetes insipidus was first described in offspring from a Long-Evans stock of rats by Dr. Schroeder, later named Brattleboro strain. In 1964 from Dr. Lewis Kinder, Harvard University, Boston to Blue Spruce Farms, Altamont, New York. to Harlan through acquisition in 1988.
Genetic Markers: Hooded
Last Known Status: Cryopreserved Embryo; Cryopreserved Sperm (as of 2018-06-21)
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23117,793,447 - 117,805,091RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.03123,117,482 - 123,119,460RGD_MAPPER_PIPELINERnor6.0
Rnor_5.03129,615,610 - 129,627,147RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.43118,205,007 - 118,206,985RGD_MAPPER_PIPELINERGSC3.4

Mutant Strains
BRAT-Avpdi/BluHsdRrrc




References

References - curated
# Reference Title Reference Citation
1. Long-term gene therapy in the CNS: reversal of hypothalamic diabetes insipidus in the Brattleboro rat by using an adenovirus expressing arginine vasopressin. Geddes BJ, etal., Nat Med. 1997 Dec;3(12):1402-4. doi: 10.1038/nm1297-1402.
2. Data registered by the Rat Resource & Research Center Personal Communication with Rat Resource & Research Center
3. Vasopressin V(2)-receptor-dependent regulation of AQP2 expression in Brattleboro rats. Promeneur D, etal., Am J Physiol Renal Physiol. 2000 Aug;279(2):F370-82.
4. RGD Strain RSO annotation pipeline RGD Automated Pipelines
5. Inherited hypothalamic diabetes insipidus in the Brattleboro strain of rats. Saul GB 2nd, etal., J Hered 1968 Mar-Apr;59(2):113-7.
6. Single base deletion in the vasopressin gene is the cause of diabetes insipidus in Brattleboro rats. Schmale H and Richter D, Nature. 1984 Apr 19-25;308(5961):705-9. doi: 10.1038/308705a0.
7. Familial hypothalamic diabetes insipidus in rats. VALTIN H, etal., Nature. 1962 Dec 15;196:1109-10.

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics Homozygous animals are smaller in body size than the heterozygotes or wild-type animals 2314654
strain_drgs_chems Lower Aqp2 mRNA and protein level were observed after treatment with AVP-V2R antagonist SR-121463A 2314654
strain_other Aqp2 expression is high 2314654
strain_reproduction Homozygous females are mated to homozygous males to produce homozygous offspring. Average litter size is 7.5. 2314654

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-06-21 BRAT-Avpdi/BluHsd  Brattleboro  HsdBlu:BRAT-Avpdi  Brattleboro  Symbol updated 68687 APPROVED