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Strain Registration

Strain: AR-Ednrbsl/Okkm

Symbol: AR-Ednrbsl/Okkm
Strain: AR-Ednrbsl
Substrain: Okkm
Full Name: Aganglionosis rat
RGD ID: 2314378
Citation ID: RRID:RGD_2314378
Ontology ID: RS:0001767
Alleles: Ednrbsl;   Ednrb
Also Known As: AR-Ednrbsl/Okkm;NBRP Rat No: 0556;AR;AR rats; AR-Ednrbsl/Okkm; AR-Ednrb^[sl]/Okkm
Type: mutant
Available Source: National BioResource Project for the Rat in Japan
Origination: National BioResource Project for the Rat in Japan
Description: Congenital megacolon rats were found in offspring of a female albino rat crossed with a wild male by Ikadai et al. at Institute for Animal Reproduction in 1973 and were named Aganglionosis Rat (AR)
Genetic Markers: Hooded
Last Known Status: Cryopreserved Embryo (as of 2016-10-31)
Research Usage Internal Organ
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21580,670,748 - 80,671,048RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01588,034,987 - 88,035,287RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01591,500,400 - 91,531,979RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41587,893,141 - 87,898,700RGD_MAPPER_PIPELINERGSC3.4






References

References - curated
# Reference Title Reference Citation
1. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
2. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Ednrbsl-var1 chr15 80670748 80671048 CCCACCCCTGGTTTCCAGACCTGCAGATCACTATCAGGTACGTTACCTTGTAGGCATTAATGGGAATGTCGATGATGATGTGTAGCAGATCTCCCAGAGCCAGGCTGGCGATCAAGATATTGGGACCATTTCTCATGCACTTGTTCTTGTAGATGATTCTTAGCAGTGTGGAGTTCCCGATGATGCCTAGCACGAACACGAGGCATGATACAATCGTGTTGATGTATTTAAAAGTCTTGTTGATCTCAATTTTTCGTTGGCACGGAGGAGGGAAGGATCTTGGCGGGACTCCAGCCACCCT - deletion mRatBN7.2
Ednrbsl-var1 chr15 88034987 88035287 CCCACCCCTGGTTTCCAGACCTGCAGATCACTATCAGGTACGTTACCTTGTAGGCATTAATGGGAATGTCGATGATGATGTGTAGCAGATCTCCCAGAGCCAGGCTGGCGATCAAGATATTGGGACCATTTCTCATGCACTTGTTCTTGTAGATGATTCTTAGCAGTGTGGAGTTCCCGATGATGCCTAGCACGAACACGAGGCATGATACAATCGTGTTGATGTATTTAAAAGTCTTGTTGATCTCAATTTTTCGTTGGCACGGAGGAGGGAAGGATCTTGGCGGGACTCCAGCCACCCT - deletion Rnor_6.0

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics AR rats are characterized by megacolon and white coat color with a small pigmented spot on the head. AR shows a long constricted segment of the intestine, which extended from the distal ileum to the rectum. Histologically, myenteric and submucosal plexus are absent. AR is considered to be an animal model of Hirshsprung???s disease. AR dies of an intestinal obstruction from 1 to 5 weeks of age. The autosomal recessive spotting lethal, sl, was revealed to be caused by a 301-bp interstitial deletion of Endothelin B receptor (Ednrb) 1302502
strain_reproduction Homozygous sl rats die within 1-5 weeks of age. The sl mutation is maintained in heterozygous condition (closed colony). 1302502

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-10-31 AR-Ednrbsl/Okkm  Aganglionosis rat  AR-EdnrbslOkkm  Aganglionosis rat  Symbol updated 68687 APPROVED
2016-04-21 AR-EdnrbslOkkm  Aganglionosis rat  AR-EdnrbSlOkkm  Aganglionosis rat  Symbol updated 68687 APPROVED
2012-09-13 AR-EdnrbSlOkkm  Aganglionosis rat  AR-EdnrbSl/Okkm  Aganglionosis rat  Symbol and/or name change 68913 APPROVED
2012-05-29 AR-EdnrbSlOkkm  Aganglionosis rat  AR-EdnrbSlOkkm  Aganglionosis rat  Name updated 68913 APPROVED
2012-05-29 AR-EdnrbSl/Okkm  Aganglionosis rat  AR-EdnrbSlOkkm  Aganglionosis rat  Symbol and/or name change 68913 APPROVED
2010-06-08 AR-EdnrbSlOkkm  Aganglionosis rat  AR-EdnrbSl/Okkm  Aganglionosis rat  Symbol and/or name change 68913 APPROVED