Strain Report - Rat Genome Database

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Strain: NMcwi:HS

Symbol: NMcwi:HS
Strain: HS
Substrain: NMcwi
Full Name: Heterogeneous stock
RGD ID: 2314009
Citation ID: RRID:RGD_2314009
Ontology ID: RS:0002539
Also Known As: HS rats
Type: outbred
Available Source: Not Available
Origination: Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin
Description: 25 breeding pairs were obtained from Dr. Eva Redei, Northwestern University (Chicago) at 55 breeding generations; these animals exhibit 30% genome-wide heterozygosity which is maintained by using a rotational breeding strategy were two parameters are used: The first is the number of cages used for breeding and the second is the spacing between each cage (containing a female for mating) and the cage to which it is mated (containing a male for mating). This spacing is called the rotational delay. A rotational delay of 1 is used, in which a female from cage 1 mates with a male from cage 2, a male from cage 2 mates with a female from cage 3, etc.
Last Known Status: Unknown


References - curated
# Reference Title Reference Citation
1. Rats are the smart choice: Rationale for a renewed focus on rats in behavioral genetics. Parker CC, etal., Neuropharmacology. 2014 Jan;76 Pt B:250-8. doi: 10.1016/j.neuropharm.2013.05.047. Epub 2013 Jun 18.
2. QTLs registered by Dr. Solberg Woods Personal communication between Dr. Leah Solberg Woods and the RGD curators.
3. RGD Strain RSO annotation pipeline RGD Automated Pipelines
4. Fine-mapping a locus for glucose tolerance using heterogeneous stock rats. Solberg Woods L, etal., Physiol Genomics. 2010 Jan 12.
5. Heterogeneous stock rats: a new model to study the genetics of renal phenotypes. Solberg Woods LC, etal., Am J Physiol Renal Physiol. 2010 Jun;298(6):F1484-91. Epub 2010 Mar 10.
6. Fine-mapping diabetes-related traits, including insulin resistance, in heterogeneous stock rats. Solberg Woods LC, etal., Physiol Genomics. 2012 Sep 4.
7. Identification of a novel gene for diabetic traits in rats, mice, and humans. Tsaih SW, etal., Genetics. 2014 Sep;198(1):17-29. doi: 10.1534/genetics.114.162982.


Strain QTL Data
Symbol Name Trait
Bw97 Body weight QTL 97 body mass   (VT:0001259)    
Gluco56 Glucose level QTL 56 blood glucose amount   (VT:0000188)    
Gluco64 Glucose level QTL 64 blood glucose amount   (VT:0000188)    
Insul17 Insulin level QTL 17 blood insulin amount   (VT:0001560)    
Insul18 Insulin level QTL 18 blood insulin amount   (VT:0001560)    
Insul19 Insulin level QTL 19 blood insulin amount   (VT:0001560)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_life_disease mean values for fasting insulin and insulin_AUC are similar to those of BUF/N 6893578