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Strain Registration

Strain: LEW.1WR1/WorBrm

Symbol: LEW.1WR1/WorBrm
Strain: LEW.1WR1
Substrain: WorBrm
RGD ID: 2313181
Citation ID: RRID:RGD_2313181
Ontology ID: RS:0002063
Previously known as: 3
Type: congenic
Source: Biomedical Research Models, Inc.
Origin: Obtained from Hanover Institute, Hanover, Germany in 1989; then maintained in a closed colony by sibling mating at Universtiy of Massachusetts, Worcester, MA then moved to Biomedical Research Models, Inc.
Last Known Status: Unknown





Experimental Data Annotations    Click to see Annotation Detail View

Rat Strain
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
LEW.1WR1/WorBrm  IEA 7241799 RGD 

Vertebrate Trait
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
blood glucose amount  EXP 2313174 RGD 

Phenotype Values via Phenominer Click to see Annotation Detail View

Related Phenotype Data for Term "LEW.1WR1/WorBrm" (RS:0002063)

Rat Strains:
Clinical Measurements:
Experimental Conditions:
Measurement Methods:
Disease Annotations     Click to see Annotation Detail View


Phenotype Values via PhenoMiner     Click to see Annotation Detail View
Options:  View chart  |  Download data table  |  View expanded data table


References

References - curated
# Reference Title Reference Citation
1. VIRUS-INDUCED AUTOIMMUNE DIABETES IN THE LEW.1WR1 RAT REQUIRES Iddm14 AND A GENETIC LOCUS PROXIMAL TO THE MAJOR HISTOCOMPATIBILITY COMPLEX. Blankenhorn EP, etal., Diabetes. 2009 Aug 31.
2. MHC and non-MHC gene regulation of disease susceptibility and disease course in experimental inflammatory peripheral neuropathy. de Graaf KL, etal., J Neuroimmunol. 2004 Oct;155(1-2):73-84.
3. LEW.1WR1 rats develop autoimmune diabetes spontaneously and in response to environmental perturbation. Mordes JP, etal., Diabetes. 2005 Sep;54(9):2727-33.
4. Analysis of the rat Iddm14 diabetes susceptibility locus in multiple rat strains: identification of a susceptibility haplotype in the Tcrb-V locus. Mordes JP, etal., Mamm Genome. 2009 Feb 10.
5. RGD Strain RSO annotation pipeline RGD Automated Pipelines
6. INFECTION WITH VIRUSES FROM SEVERAL FAMILIES TRIGGERS AUTOIMMUNE DIABETES IN LEW.1WR1 RATS: Prevention of Diabetes by Maternal Immunization. Tirabassi RS, etal., Diabetes. 2009 Sep 30.

Region

Strain QTL Data
Symbol Name Trait
Iddm37 Insulin dependent diabetes mellitus QTL 37 blood glucose amount   (VT:0000188)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics median age of onset is 59 days and mean plasma glucose concentration was 535 mg/dl at the time of diagnosis 2313175
strain_life_disease Diabetes is not induced by H-1, vaccinia, and Coxsackie B4 viruses. 2313609
strain_life_disease when infected with Kilham rat virus, 100% diabetes was induced; treatment with poly I:C results in the development of diabetes; cytomegalovirus and vaccinia virus also induce diabetes 2313174
strain_other These have the MHC recombinant haplotype 1RTAuB/DuCa, ART2a which are required for autoimmune diseases 2313174