Strain Report - Rat Genome Database

Name: BBDR.BBDP-( D4Rhw11-D4Rhw10 )/Rhw
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Strain Registration

General

Strain: BBDR.BBDP-(D4Rhw11-D4Rhw10)/Rhw

Symbol:

BBDR.BBDP-(D4Rhw11-D4Rhw10)/Rhw

Strain:

BBDR.BBDP-(D4Rhw11-D4Rhw10)

Substrain:

Rhw

RGD ID:

2306529

Citation ID:

RRID:RGD_2306529

Ontology ID:

RS:0001772

Previously known as:

BBDR.BBDP-(D4Rhw11-D4Rhw10)/Rhw;DR.lyp/lyp;DR.lyp/lyp; BBDR.BBDP-(D4Rhw11-D4Rhw10)/Rhw

Type:

congenic

Source:

Department of Medicine, University of Washington, Seattle, Washington

Origin:

Parental strain BBDR.BBDP-(D4Rhw17-ss99306861)(D4Rhw11-D4Rhw10)/Rhw were backcrossed to BBDR/Rhw, carefully DNA between D4Rhw17-ss99306861 was removed giving the desired congenic

Inbred Generations:

Last Known Status:

Unknown

Position

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	76,721,312 - 78,654,798	RGD_MAPPER_PIPELINE	mRatBN7.2
Rnor_6.0	4	77,380,565 - 79,326,833	RGD_MAPPER_PIPELINE	Rnor6.0
Rnor_5.0	4	142,052,025 - 144,005,977	RGD_MAPPER_PIPELINE	Rnor5.0
RGSC_v3.4	4	75,808,584 - 77,809,321	RGD_MAPPER_PIPELINE	RGSC3.4

Congenic Strains

BBDR.F344-(D4Arb11-D4Rat27),BBDP-(D4Rhw11-D4Rhw10)/Rhw

BBDR.F344-(D4Rat102-D4Rat27),BBDP-(D4Rhw11-D4Rhw10)/Rhw

BBDR.F344-(D4Rat153-D4Rat27),BBDP-(D4Rhw11-D4Rhw10)/Rhw

BBDR.F344-(D4Rat253-D4Rat27),BBDP-(D4Rhw11-D4Rhw10)/Rhw

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

lymphopenia (IAGP)

type 1 diabetes mellitus (IAGP)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

decreased alpha-beta T cell number (IAGP)

decreased T cell number (IAGP)

increased susceptibility to autoimmune diabetes (IAGP)

insulitis (IAGP)

periinsulitis (IAGP)

Phenotype Values via PhenoMiner Click to see Annotation Detail View

Options:

View chart

Download data table

View expanded data table

Clinical Measurement

blood R73 cell to total mononuclear cell ratio

References

References - curated

#	Reference Title	Reference Citation
1.	Introgression of F344 Rat Genomic DNA on BB Rat Chromosome 4 Generates Diabetes-Resistant Lymphopenic BB Rats.	Fuller JM, etal., Diabetes. 2006 Dec;55(12):3351-7.
2.	Genetic Dissection Reveals Diabetes Loci Proximal to the Gimap5 Lymphopenia Gene.	Fuller JM, etal., Physiol Genomics. 2009 Apr 7.
3.	BB rat Gimap gene expression in sorted lymphoid T and B cells.	Moralejo DH, etal., Life Sci. 2011 Nov 7;89(19-20):748-54. Epub 2011 Sep 10.
4.	RGD Strain RSO annotation pipeline	RGD Automated Pipelines
5.	Sequence variation and expression of the Gimap gene family in the BB rat.	Rutledge EA, etal., Exp Diabetes Res. 2009;2009:835650. Epub 2009 May 3.

Region

Position Markers

Flank 1 / 1 (D4Rhw11)

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	4	76,721,312 - 76,721,521 (+)	MAPPER
Rnor_6.0	4	77,380,565 - 77,380,773	NCBI
Rnor_5.0	4	142,052,025 - 142,052,233	UniSTS
RGSC_v3.4	4	75,808,584 - 75,808,792	UniSTS
Celera	4	71,525,933 - 71,526,133	UniSTS
Cytogenetic Map	4	q24	RGD

Flank 2 / 1 (D4Rhw10)

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	4	78,654,527 - 78,654,798 (+)	MAPPER
Rnor_6.0	4	79,326,563 - 79,326,833	NCBI
Rnor_5.0	4	144,005,707 - 144,005,977	UniSTS
RGSC_v3.4	4	77,809,051 - 77,809,321	UniSTS
Celera	4	73,568,949 - 73,569,219	UniSTS
Cytogenetic Map	4	q24	RGD

Additional Information

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Strain: BBDR.BBDP-(D4Rhw11-D4Rhw10)/Rhw

Related Phenotype Data for Term "BBDR.BBDP-(D4Rhw11-D4Rhw10)/Rhw" (RS:0001772)