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Strain: WIC-Tgrdw/Kts

Symbol: WIC-Tgrdw/Kts
Strain: WIC-Tgrdw
Substrain: Kts
RGD ID: 2304039
Citation ID: RRID:RGD_2304039
Ontology ID: RS:0002259
Alleles: Tgrdw
Also Known As: WIC-Tgm1Kts; WIC-Tgrdw/Kts; WIC-Tgrdw/Kts; NBRP Rat No: 0104; rdw; WIC-rdw; WIC-rdw; WI-TgrdwKts; WIC-Tgrdw/Kts; WIC-Tg^[rdw]/Kts
Type: mutant
Available Source: National BioResource Project for the Rat in Japan
Origination: School of Medicine, Kitasato University
Description: Established from a closed colony of Wistar-Imamichi (WIC) rats as a spontaneous mutant exhibiting congenital dwarfism (rdw), is inherited as an autosomal recessive. This strain has a spontaneous missense mutation, G2320R, in the thyroglobul gene.
Inbred Generations: F15
Last Known Status: Cryopreserved Embryo; Cryopreserved Sperm (as of 2017-04-21)
Research Usage Metabolism
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2798,517,376 - 98,517,376RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.07107,567,063 - 107,567,063RGD_MAPPER_PIPELINERnor6.0
Rnor_5.07107,399,165 - 107,602,400RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.47104,035,776 - 104,220,754RGD_MAPPER_PIPELINERGSC3.4

Mutant Strains
F344.WIC-TgrdwKts




Disease Annotations     Click to see Annotation Detail View


References

References - curated
# Reference Title Reference Citation
1. Rescue from dwarfism by thyroid function compensation in rdw rats. Furudate S, etal., Exp Anim. 2005 Oct;54(5):455-60. doi: 10.1538/expanim.54.455.
2. A novel missense mutation (G2320R) in thyroglobulin causes hypothyroidism in rdw rats. Hishinuma A, etal., Endocrinology 2000 Nov;141(11):4050-5.
3. [rdw rats, a new hereditary dwarf model in the rat]. Koto M, etal., Jikken Dobutsu. 1988 Jan;37(1):21-30.
4. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
5. RGD Strain RSO annotation pipeline RGD Automated Pipelines
6. Missing secretory granules, dilated endoplasmic reticulum, and nuclear dislocation in the thyroid gland of rdw rats with hereditary dwarfism. Sakai Y, etal., Anat Rec. 2000 May 1;259(1):60-6.

Region

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Tgrdw-var1 chr7 98517376 98517376 G C point_mutation mRatBN7.2
Tgrdw-var1 chr7 107567063 107567063 G C point_mutation Rnor_6.0

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics A missense mutation, G2320R, in the Tg gene is responsible for the rdw mutation in the WIC-rdw rat. 1302502
strain_phys_biochem elevated molecular chaperone levels were observed in the thyrocytes 1302502
strain_reproduction Homozygous rdw rats are infertile in both sexes. So, the mutant rats are maintained as a segregating inbred strain. 1302502

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-04-28 WIC-Tgrdw/Kts    WIC-TgrdwKts    Symbol updated 68687 APPROVED
2017-04-28 WIC-Tgrdw/Kts    WIC-TgrdwKts    Symbol updated 68687 APPROVED
2017-04-21 WIC-TgrdwKts    WI-TgrdwKts    Symbol updated 68687 APPROVED
2017-04-21 WIC-TgrdwKts    WI-TgrdwKts    Symbol updated 68687 APPROVED
2012-05-09 WIC-TgrdwKts    WIC-TgrdwKts    Name updated 68913 APPROVED
2010-06-08 WIC-TgrdwKts/    WIC-Tgrdw/Kts    Symbol updated 68687 APPROVED
2010-06-08 WIC-TgrdwKts/    WIC-Tgrdw/Kts    Symbol updated 68687 APPROVED
2010-06-08 WIC-TgrdwKts    WIC-TgrdwKts/    Name updated 68913 APPROVED
2010-06-08 WIC-TgrdwKts    WIC-TgrdwKts/    Symbol updated 68687 APPROVED
2010-06-08 WIC-TgrdwKts    WIC-TgrdwKts/    Name updated 68913 APPROVED
2010-06-08 WIC-TgrdwKts    WIC-TgrdwKts/    Symbol updated 68687 APPROVED
2010-06-08 WIC-TgrdwKts/    WIC-Tgrdw/Kts    Name updated 68913 APPROVED
2010-06-08 WIC-TgrdwKts/    WIC-Tgrdw/Kts    Name updated 68913 APPROVED