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Strain Registration

Strain: WT/Jtt

Symbol: WT/Jtt
Strain: WT
Substrain: Jtt
Full Name: whitish teeth rat
RGD ID: 2303759
Citation ID: RRID:RGD_2303759
Ontology ID: RS:0003249
Also Known As: NBRP Rat No: 0219
Type: inbred
Available Source: National BioResource Project for the Rat in Japan
Origination: National BioResource Project for the Rat in Japan
Description: In 2001, abnormal incisors that had deteriorated and had a whitish chalk-like appearance were unexpectedly discovered in one male rat among Sprague-Dawley [Crj:CD(SD)IGS] rats (Masuyama, 2005). After that, this mutant phenotype was maintained by sib-mating.
Inbred Generations: F22
Last Known Status: Cryopreserved Embryo; Cryopreserved Sperm (as of 2024-09-24)
Research Usage Dentistry





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Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. A novel autosomal-recessive mutation, whitish chalk-like teeth, resembling amelogenesis imperfecta, maps to rat chromosome 14 corresponding to human 4q21. Masuyama T, etal., Eur J Oral Sci. 2005 Dec;113(6):451-6. doi: 10.1111/j.1600-0722.2005.00254.x.
2. Rat wct mutation induces a hypo-mineralization form of amelogenesis imperfecta and cyst formation in molar teeth. Osawa M, etal., Cell Tissue Res. 2007 Oct;330(1):97-109. Epub 2007 Aug 21.
3. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
4. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics The whitish chalk-like teeth (wct) mutation maps to rat chromosome 14 between D14Got13 and D14Wox2. 1302502
strain_life_disease homozygous mutants exhibit defective tooth enamel 2303758

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-05-25 WT/Jtt  whitish teeth rat  WT/Jtt    Name updated 68913 APPROVED