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Strain: Scr:sP

Symbol: Scr:sP
Strain: sP
Substrain: Scr
Full Name: Sardinian alcohol-preferring rats
RGD ID: 2302666
Citation ID: RRID:RGD_2302666
Ontology ID: RS:0001707
Previously known as: sP/Scr
Type: outbred
Source: The Scripps Research Institute, LaJolla, California
Origin: sP/Scr rats are derived from the selectively bred Sardinian alcohol-preferring rats (sP). This colony began with founders obtained after 32 generations of selective breeding for ethanol preference from Wistar stock by Prof. G.L. Gessa (University of Cagliari). Since receipt, this substrain has been maintained at the Scripps Institute for 24 generations of intra-line, unselected breeding.
Inbred Generations: F24
Last Known Status: Unknown

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype


References - curated
# Reference Title Reference Citation
1. RGD Strain RSO annotation pipeline RGD Automated Pipelines
2. The sigma-Receptor Antagonist BD-1063 Decreases Ethanol Intake and Reinforcement in Animal Models of Excessive Drinking. Sabino V, etal., Neuropsychopharmacology. 2008 Oct 22.
3. Dissociation between opioid and CRF1 antagonist sensitive drinking in Sardinian alcohol-preferring rats. Sabino V, etal., Psychopharmacology (Berl). 2006 Dec;189(2):175-86. Epub 2006 Oct 18.
4. 14-Methoxymetopon, a highly potent mu opioid agonist, biphasically affects ethanol intake in Sardinian alcohol-preferring rats. Sabino V, etal., Psychopharmacology (Berl). 2007 Jul;192(4):537-46. Epub 2007 Mar 8.


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_drgs_chems They can maintain a constant intake of alcohol by voluntarily consuming 5-7g of ethanol/kg body weight per day 2302663