Strain Report - Rat Genome Database

Name: BN.GH-( D2Rat22-D2Mgh11 )/Mcwi
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Strain Registration

General

Strain: BN.GH-(D2Rat22-D2Mgh11)/Mcwi

Symbol:

BN.GH-(D2Rat22-D2Mgh11)/Mcwi

Strain:

BN.GH-(D2Rat22-D2Mgh11)

Substrain:

Mcwi

RGD ID:

2301939

Citation ID:

RRID:RGD_2301939

Ontology ID:

RS:0001668

Previously known as:

BN.GH2;BN.GH-(D2Rat22-D2Mgh11)/Mcwi; BN.GH-(D2Rat22-D2Mgh11)/Mcwi

Type:

congenic

Source:

Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, Wisconsin

Origin:

Male GH/Omr were intercrossed with female BN/Elh then F1 male offspring was backcrossed to female BN/Elh, marker-assisted selection strategy was used to select the males who were backcrossed to BN for 10 generations

Last Known Status:

Unknown

Position

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	68,462,860 - 189,039,377	RGD_MAPPER_PIPELINE	mRatBN7.2
Rnor_6.0	2	69,243,686 - 204,022,555	RGD_MAPPER_PIPELINE	Rnor6.0
Rnor_5.0	2	88,968,735 - 223,460,027	RGD_MAPPER_PIPELINE	Rnor5.0
RGSC_v3.4	2	69,302,718 - 69,303,085	RGD_MAPPER_PIPELINE	RGSC3.4

Congenic Strains

BN.GH-(D2Rat22-D2Mgh11)(D18Rat41-D18Mgh4)/Mcwi

BN.GH-(D2Rat22-D2Mgh11)(D6Mit12-D6Rat15)/Mcwi

Annotation Click to see Annotation Detail View

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal baroreceptor physiology (IAGP)

Phenotype Values via PhenoMiner Click to see Annotation Detail View

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Clinical Measurement

heart rate

systolic blood pressure

diastolic blood pressure

mean arterial blood pressure

body weight

heart left ventricle wet weight

kidney wet weight

heart left ventricle weight to body weight ratio

single kidney wet weight to body weight ratio

change in mean arterial blood pressure to change in vasoactive chemical dose ratio

References

References - curated

#	Reference Title	Reference Citation
1.	Genetically Hypertensive Brown Norway congenic rat strains suggest intermediate traits underlying genetic hypertension.	Bilusic M, etal., Croat Med J. 2008 Oct;49(5):586-99.
2.	RGD Strain RSO annotation pipeline	RGD Automated Pipelines

Region

Position Markers

Flank 1 / 1 (D2Rat22)

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	2	68,462,860 - 68,462,973 (+)	MAPPER
Rnor_6.0	2	69,243,686 - 69,243,798	NCBI
Rnor_5.0	2	88,968,735 - 88,968,847	UniSTS
RGSC_v3.4	2	69,302,718 - 69,303,085	RGD
RGSC_v3.4	2	69,302,723 - 69,302,835	UniSTS
RGSC_v3.1	2	69,230,956 - 69,231,068	RGD
Celera	2	64,332,321 - 64,332,433	UniSTS
RH 3.4 Map	2	435.4	UniSTS
RH 3.4 Map	2	435.4	RGD
SHRSP x BN Map	2	29.7798	UniSTS
SHRSP x BN Map	2	29.7798	RGD

Flank 2 / 1 (D2Mgh11)

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	2	189,039,155 - 189,039,377 (+)	MAPPER
Rnor_6.0	2	204,022,334 - 204,022,555	NCBI
Rnor_5.0	2	223,459,806 - 223,460,027	UniSTS
Celera	2	181,473,981 - 181,474,202	UniSTS
RH 3.4 Map	2	1294.1	UniSTS
RH 3.4 Map	2	1294.1	RGD
RH 2.0 Map	2	967.0	RGD
SHRSP x BN Map	2	72.7598	RGD
Cytogenetic Map	2	q34	UniSTS

Additional Information

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Strain: BN.GH-(D2Rat22-D2Mgh11)/Mcwi

Mammalian Phenotype

Related Phenotype Data for Term "BN.GH-(D2Rat22-D2Mgh11)/Mcwi" (RS:0001668)