Strain Report - Rat Genome Database

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Strain: SS.LEW-(D18Chm41-D18Rat92)/Ayd

Symbol: SS.LEW-(D18Chm41-D18Rat92)/Ayd
Strain: SS.LEW-(D18Chm41-D18Rat92)
Substrain: Ayd
RGD ID: 2301381
Citation ID: RRID:RGD_2301381
Ontology ID: RS:0001654
Previously known as: C18S.L3;DSS X LEW-(D18Chm41-D18Rat92)/Lt;SS.LEW-(D18Chm41-D18Rat92)/Ayd; SS.LEW-(D18Rat101-D18Rat92)/Ayd; SS.LEW-(D18Rat101-D18Rat92)/Ayd; SS.LEW-(D18Chm41-D18Rat92)/Ayd
Type: congenic
Source: Research Centre-CHUM, Montreal, Quebec, Canada
Origin: SS/Jr and LEW/Crlc were backcrossed for 5 generations, then BC5 rat was mated with LEW/Crlc to produce the desired congenic strain
Last Known Status: Unknown
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21829,804,982 - 51,515,008RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01831,109,532 - 53,083,766RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01830,797,572 - 52,299,753RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41830,891,173 - 53,898,282RGD_MAPPER_PIPELINERGSC3.4


References - curated
# Reference Title Reference Citation
1. A loss of genome buffering capacity of Dahl salt-sensitive model to modulate blood pressure as a cause of hypertension. Charron S, etal., Hum Mol Genet. 2005 Dec 15;14(24):3877-84. Epub 2005 Nov 8.
2. Modularization and epistatic hierarchy determine homeostatic actions of multiple blood pressure quantitative trait loci. Chauvet C, etal., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28.
3. Combining distinctive and novel loci doubles BP reduction, reverses diastolic dysfunction and mitigates LV hypertrophy. Crespo K, etal., J Hypertens. 2013 May;31(5):927-35. doi: 10.1097/HJH.0b013e32835edc7e.
4. Distinct genomic replacements from Lewis correct diastolic dysfunction, attenuate hypertension, and reduce left ventricular hypertrophy in Dahl salt-sensitive rats. Deng AY, etal., J Hypertens. 2008 Oct;26(10):1935-1943.
5. Distinct quantitative trait loci for kidney, cardiac, and aortic mass dissociated from and associated with blood pressure in Dahl congenic rats. Duong C, etal., Mamm Genome. 2006 Dec;17(12):1147-61. Epub 2006 Dec 1.
6. RGD Strain RSO annotation pipeline RGD Automated Pipelines


Position Markers

Flank 1 / 1 (D18Chm41)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21829,804,982 - 29,805,189 (+)MAPPER
Rnor_6.01831,109,532 - 31,109,736NCBI
Rnor_5.01830,797,572 - 30,797,776UniSTS
RGSC_v3.41830,891,173 - 30,891,377UniSTS
Celera1829,449,567 - 29,449,769UniSTS
Cytogenetic Map18p11UniSTS

Flank 2 / 1 (D18Rat92)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21851,514,825 - 51,515,008 (+)MAPPER
Rnor_6.01853,083,584 - 53,083,766NCBI
Rnor_5.01852,299,571 - 52,299,753UniSTS
Rnor_5.01852,255,071 - 52,255,253UniSTS
RGSC_v3.41853,898,100 - 53,898,282UniSTS
RGSC_v3.41853,898,099 - 53,898,282RGD
RGSC_v3.11853,962,000 - 53,962,432RGD
Celera1849,643,148 - 49,643,330UniSTS
SHRSP x BN Map1820.5099UniSTS
SHRSP x BN Map1820.5099RGD
Cytogenetic Map18q12.1UniSTS
Strain QTL Data
Symbol Name Trait
Am19 Aortic mass QTL 19 aorta mass   (VT:0002845)    
Bp318 Blood pressure QTL 318 arterial blood pressure trait   (VT:2000000)    
Bp348 Blood pressure QTL 348 arterial blood pressure trait   (VT:2000000)    
Bw188 Body weight QTL 188 body mass   (VT:0001259)    
Cm125 Cardiac mass QTL 125 heart mass   (VT:0007028)    
Cm126 Cardiac mass QTL 126 heart left ventricle mass   (VT:0007031)    
Cm127 Cardiac mass QTL 127 heart right ventricle mass   (VT:0007033)    
Kidm72 Kidney mass QTL 72 kidney mass   (VT:0002707)    

Additional Information