Strain Report - Rat Genome Database

Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap)  (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Overgo Probe Designer
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Strain Registration

Strain: SS.LEW-(D18Chm41-D18Rat92)/Ayd

Symbol: SS.LEW-(D18Chm41-D18Rat92)/Ayd
Strain: SS.LEW-(D18Chm41-D18Rat92)
Substrain: Ayd
RGD ID: 2301381
Citation ID: RRID:RGD_2301381
Ontology ID: RS:0001654
Previously known as: C18S.L3;DSS X LEW-(D18Chm41-D18Rat92)/Lt;SS.LEW-(D18Chm41-D18Rat92)/Ayd; SS.LEW-(D18Rat101-D18Rat92)/Ayd; SS.LEW-(D18Rat101-D18Rat92)/Ayd; SS.LEW-(D18Chm41-D18Rat92)/Ayd
Type: congenic
Source: Research Centre-CHUM, Montreal, Quebec, Canada
Origin: SS/Jr and LEW/Crlc were backcrossed for 5 generations, then BC5 rat was mated with LEW/Crlc to produce the desired congenic strain
Last Known Status: Unknown
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21829,804,982 - 51,515,008RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01831,109,532 - 53,083,766RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01830,797,572 - 52,299,753RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41830,891,173 - 53,898,282RGD_MAPPER_PIPELINERGSC3.4





References

References - curated
# Reference Title Reference Citation
1. A loss of genome buffering capacity of Dahl salt-sensitive model to modulate blood pressure as a cause of hypertension. Charron S, etal., Hum Mol Genet. 2005 Dec 15;14(24):3877-84. Epub 2005 Nov 8.
2. Modularization and epistatic hierarchy determine homeostatic actions of multiple blood pressure quantitative trait loci. Chauvet C, etal., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28.
3. Combining distinctive and novel loci doubles BP reduction, reverses diastolic dysfunction and mitigates LV hypertrophy. Crespo K, etal., J Hypertens. 2013 May;31(5):927-35. doi: 10.1097/HJH.0b013e32835edc7e.
4. Distinct genomic replacements from Lewis correct diastolic dysfunction, attenuate hypertension, and reduce left ventricular hypertrophy in Dahl salt-sensitive rats. Deng AY, etal., J Hypertens. 2008 Oct;26(10):1935-1943.
5. Distinct quantitative trait loci for kidney, cardiac, and aortic mass dissociated from and associated with blood pressure in Dahl congenic rats. Duong C, etal., Mamm Genome. 2006 Dec;17(12):1147-61. Epub 2006 Dec 1.
6. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region

Position Markers

Flank 1 / 1 (D18Chm41)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21829,804,982 - 29,805,189 (+)MAPPER
Rnor_6.01831,109,532 - 31,109,736NCBI
Rnor_5.01830,797,572 - 30,797,776UniSTS
RGSC_v3.41830,891,173 - 30,891,377UniSTS
Celera1829,449,567 - 29,449,769UniSTS
Cytogenetic Map18p11UniSTS

Flank 2 / 1 (D18Rat92)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21851,514,825 - 51,515,008 (+)MAPPER
Rnor_6.01853,083,584 - 53,083,766NCBI
Rnor_5.01852,299,571 - 52,299,753UniSTS
Rnor_5.01852,255,071 - 52,255,253UniSTS
RGSC_v3.41853,898,100 - 53,898,282UniSTS
RGSC_v3.41853,898,099 - 53,898,282RGD
RGSC_v3.11853,962,000 - 53,962,432RGD
Celera1849,643,148 - 49,643,330UniSTS
SHRSP x BN Map1820.5099UniSTS
SHRSP x BN Map1820.5099RGD
Cytogenetic Map18q12.1UniSTS
Strain QTL Data
Symbol Name Trait
Am19 Aortic mass QTL 19 aorta mass   (VT:0002845)    
Bp318 Blood pressure QTL 318 arterial blood pressure trait   (VT:2000000)    
Bp348 Blood pressure QTL 348 arterial blood pressure trait   (VT:2000000)    
Bw188 Body weight QTL 188 body mass   (VT:0001259)    
Cm125 Cardiac mass QTL 125 heart mass   (VT:0007028)    
Cm126 Cardiac mass QTL 126 heart left ventricle mass   (VT:0007031)    
Cm127 Cardiac mass QTL 127 heart right ventricle mass   (VT:0007033)    
Kidm72 Kidney mass QTL 72 kidney mass   (VT:0002707)    

Additional Information