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Strain Registration

Strain: Kini:DA,PVG-G10

Symbol: Kini:DA,PVG-G10
Strain: DA,PVG-G10
Substrain: Kini
RGD ID: 2298494
Citation ID: RRID:RGD_2298494
Ontology ID: RS:0001339
Type: advanced_intercross_line
Source: Center for Molecular Medicine, Neuroimmunology Unit, Karolinska Institutet, Stockholm, Sweden
Origin: Two breeding pairs from inbred DA/Han and PVG.1AV1 that share the RT.1AV1 MHC haplotype were bred to create F1 generation, 7 couples of F1 with DA/Han and PVG.1AV1 females founders generated F2. F3 generation originated from breeding 50 random couples
Inbred Generations: G10
Last Known Status: Unknown





Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. New loci regulating rat myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis. Becanovic K, etal., J Immunol 2003 Jan 15;170(2):1062-9.
2. An advanced intercross line resolves Eae18 into two narrow quantitative trait loci syntenic to multiple sclerosis candidate loci. Jagodic M, etal., J Immunol 2004 Jul 15;173(2):1366-73.
3. RGMA and IL21R show association with experimental inflammation and multiple sclerosis. Nohra R, etal., Genes Immun. 2010 Jun;11(4):279-93. Epub 2010 Jan 14.
4. Definition of a 1.06-Mb region linked to neuroinflammation in humans, rats and mice. Ockinger J, etal., Genetics. 2006 Jul;173(3):1539-45. Epub 2006 Apr 19.
5. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region

Strain QTL Data
Symbol Name Trait
Eae23 Experimental allergic encephalomyelitis QTL 23 nervous system integrity trait   (VT:0010566)    
Eae30 Experimental allergic encephalomyelitis QTL 30 nervous system integrity trait   (VT:0010566)    
Eae31 Experimental allergic encephalomyelitis QTL 31 nervous system integrity trait   (VT:0010566)    
Eae32 Experimental allergic encephalomyelitis QTL 32 nervous system integrity trait   (VT:0010566)    
Eae33 Experimental allergic encephalomyelitis QTL 33 nervous system integrity trait   (VT:0010566)    
Pia41 Pristane induced arthritis QTL 41 joint integrity trait   (VT:0010548)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_life_disease disease was observed more in females 2293859
strain_life_disease induced by myelin oligodendrocyte glycoprotein aa1-125 2293859