Strain Report - Rat Genome Database

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Strain: ACI.COP-(D3Rat130-D3Rat114)/Shul

Symbol: ACI.COP-(D3Rat130-D3Rat114)/Shul
Strain: ACI.COP-(D3Rat130-D3Rat114)
Substrain: Shul
RGD ID: 2292566
Citation ID: RRID:RGD_2292566
Ontology ID: RS:0001160
Previously known as: ACI.COP-Ept2; ACI.COP-Ept2; Ept2; ACI.COP-(D3Rat130-D3Rat114)/Shul
Type: congenic
Source: Department of Genetics, Cell Biology and Anatomy, University Of Nebraska Medical Center, Omaha, Nebraska
Origin: Female COP/CrCrl and male ACI/SegHsd were crossed to get F1 progeny which were in turn backcrossed with female ACI/SegHsd; the offsprings were genotyped
Last Known Status: Unknown
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2347,233,211 - 147,415,807RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0348,561,928 - 155,263,151RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0355,227,530 - 160,347,840RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.4344,551,252 - 149,496,698RGD_MAPPER_PIPELINERGSC3.4

Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
Options:  View chart  |  Download data table  |  View expanded data table

Clinical Measurement
mammary tumor number


References - curated
# Reference Title Reference Citation
1. Tissue-Specific Actions of the Ept1, Ept2, Ept6, and Ept9 Genetic Determinants of Responsiveness to Estrogens in the Female Rat. Kurz SG, etal., Endocrinology. 2008 Apr 17;.
2. RGD Strain RSO annotation pipeline RGD Automated Pipelines
3. Tamoxifen induces regression of estradiol-induced mammary cancer in the ACI.COP-Ept2 rat model. Ruhlen RL, etal., Breast Cancer Res Treat. 2008 Sep 9.


Position Markers

Flank 1 / 1 (D3Rat130)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2347,233,211 - 47,233,430 (+)MAPPER
Rnor_6.0348,561,928 - 48,562,146NCBI
Rnor_5.0355,227,530 - 55,227,748UniSTS
RGSC_v3.4344,551,324 - 44,551,542UniSTS
RGSC_v3.4344,551,252 - 44,551,542RGD
RGSC_v3.1344,447,696 - 44,447,914RGD
Celera346,874,375 - 46,874,593UniSTS
RH 3.4 Map3601.73RGD
RH 3.4 Map3601.73UniSTS
RH 2.0 Map3376.6RGD
SHRSP x BN Map332.8199RGD
FHH x ACI Map332.74RGD
Cytogenetic Map3q21UniSTS

Flank 2 / 1 (D3Rat114)
Rat AssemblyChrPosition (strand)Source
mRatBN7.23147,415,594 - 147,415,807 (+)MAPPER
Rnor_6.03155,262,939 - 155,263,151NCBI
Rnor_5.03160,347,628 - 160,347,840UniSTS
RGSC_v3.43149,496,486 - 149,496,698UniSTS
RGSC_v3.43149,496,485 - 149,496,698RGD
RGSC_v3.13149,402,395 - 149,402,607RGD
Celera3146,112,164 - 146,112,376UniSTS
RH 3.4 Map31360.0RGD
RH 3.4 Map31360.0UniSTS
RH 2.0 Map3919.7RGD
SHRSP x BN Map375.5198RGD
FHH x ACI Map388.0299RGD
Cytogenetic Map3q42UniSTS
Strain QTL Data
Symbol Name Trait
Ept16 Estrogen-induced pituitary tumorigenesis QTL 16 pituitary gland mass   (VT:0010496)    
Ept17 Estrogen-induced pituitary tumorigenesis QTL 17 pituitary gland mass   (VT:0010496)    
Esta4 Estrogen-induced thymic atrophy QTL 4 thymus mass   (VT:0004954)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_drgs_chems MRI measurements showed a decrease of tumor mass by 89% after treatment with tamoxifen for 3 weeks 2301340
strain_other COP allele inhibited the induction of pituitary growth by E2 2292503

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-11-07 ACI.COP-(D3Rat130-D3Rat114)/Shul    ACI.COP-(D3Rat130-D3Rat114)/Shul    Name updated 68913 APPROVED
2014-11-07 ACI.COP-(D3Rat130-D3Rat114)/Shul    ACI.COP-(D3Rat130-D3Rat114)/Shul    Name updated 68913 APPROVED