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Strain: SHR-Camk2n1em1Tja-/-

Symbol: SHR-Camk2n1em1Tja-/-
Strain: SHR-Camk2n1em1-/-
Substrain: Tja
Full Name: SHR-Camk2n1em1Tja-/Camk2n1em1Tja-
RGD ID: 19259464
Citation ID: RRID:RGD_19259464
Ontology ID: RS:0005026
Alleles: Camk2n1em1Tja
Type: mutant
Source: Not Available
Origin: SHR-Camk2n1-/- knockout rats were generated on an SHR/NCrl background by microinjecting zinc-finger nuclease (ZFN) mRNA (Sigma), targeted to exon 1 of Camk2n1, into one-cell stage SHR/NCrl embryos that were implanted into pseudopregnant rats. Heterozygous progeny, from a founder harboring a 38bp deletion in Camk2n1, were intercrossed to generate homozygous knockout rats.
Genetic Status: Homozygous
Last Known Status: Unknown
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25150,674,819 - 150,676,600RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.05156,876,706 - 156,878,486RGD_MAPPER_PIPELINERnor6.0
Rnor_5.05160,625,616 - 160,627,396RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.45157,235,534 - 157,237,314RGD_MAPPER_PIPELINERGSC3.4


References - curated
# Reference Title Reference Citation
1. Camk2n1 Is a Negative Regulator of Blood Pressure, Left Ventricular Mass, Insulin Sensitivity, and Promotes Adiposity. Alfazema N, etal., Hypertension. 2019 Sep;74(3):687-696. doi: 10.1161/HYPERTENSIONAHA.118.12409. Epub 2019 Jul 22.


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